Neurodegenerative evidences during early onset of depression in CMS rats as detected by proton magnetic resonance spectroscopy at 7 T

Kumar, B.S. Hemanth; Mishra, Sushanta Kumar; Rana, Poonam; Singh, Sadhana; Khushu, Subash

doi:10.1016/j.bbr.2012.03.011

Cited by 54 publications

(43 citation statements)

References 46 publications

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“…Delgado et al positioned a 2 mm 3 voxel in the ventral part of the left hippocampus whereas Huang et al (2016) positioned their 2.5 × 4 × 4 mm voxel in the dorsal area of the right hippocampus. Similar decreases in dorsal hippocampal glutamate have been reported in rats bred for learned helplessness (cLH) compared to Sprague-Dawley controls and also following CMS (Hemanth Kumar et al, 2012; Schulz et al, 2013). …”

Section: Mri In Animal Models Of Depressionsupporting

confidence: 56%

“…Similarly, chronic exposure to the FST has been reported to decrease the glutamate signal in both the prefrontal cortex and hippocampus in rats (Li et al, 2008). Reductions in the combined glutamate and glutamine signal have also been reported in the prefrontal cortex of mice exposed to CMS (Hemanth Kumar et al, 2012). In contrast, Delgado y Palacios et al (2011) report increased hippocampal glutamate levels in animals susceptible to CMS compared to both resilient and control groups.…”

Section: Mri In Animal Models Of Depressionmentioning

confidence: 84%

“…Preclinical MRS studies have shown increased hippocampal myoinositol levels following both CMS (Hemanth Kumar et al, 2012) and the acute FST (Kim et al, 2010). Similarly, increased mI levels have been observed in the amygdala following chronic psychosocial stress (Grandjean et al, 2016).…”

Section: Mri In Animal Models Of Depressionmentioning

confidence: 99%

“…Alterations in the N-acetyl aspartic acid (NAA), a marker commonly used to indicate neuronal integrity have also been reported, with decreased hippocampal NAA levels following both mild and unpredictable chronic stress paradigms (Xi et al, 2011; Hemanth Kumar et al, 2012) as well as chronic exposure to the FST (Li et al, 2008). Xi et al (2011) report that hippocampal NAA reductions were normalized by chronic escitalopram treatment (4 weeks).…”

Section: Mri In Animal Models Of Depressionmentioning

confidence: 99%

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Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression

McIntosh

Gormley

Tozzi

et al. 2017

Front. Cell. Neurosci.

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Magnetic resonance imaging (MRI) is a valuable translational tool that can be used to investigate alterations in brain structure and function in both patients and animal models of disease. Regional changes in brain structure, functional connectivity, and metabolite concentrations have been reported in depressed patients, giving insight into the networks and brain regions involved, however preclinical models are less well characterized. The development of more effective treatments depends upon animal models that best translate to the human condition and animal models may be exploited to assess the molecular and cellular alterations that accompany neuroimaging changes. Recent advances in preclinical imaging have facilitated significant developments within the field, particularly relating to high resolution structural imaging and resting-state functional imaging which are emerging techniques in clinical research. This review aims to bring together the current literature on preclinical neuroimaging in animal models of stress and depression, highlighting promising avenues of research toward understanding the pathological basis of this hugely prevalent disorder.

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Section: Mri In Animal Models Of Depressionsupporting

confidence: 56%

Section: Mri In Animal Models Of Depressionmentioning

confidence: 84%

Section: Mri In Animal Models Of Depressionmentioning

confidence: 99%

Section: Mri In Animal Models Of Depressionmentioning

confidence: 99%

See 2 more Smart Citations

Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression

McIntosh

Gormley

Tozzi

et al. 2017

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Magnetic resonance spectroscopy placed this GABA attenuation at 52% in humans – remarkably similar to what we observed in our MS rats. In a single animal study to examine GABA levels with magnetic resonance spectroscopy, Kumar et al [33] found a decrease in GABA levels following exposure to chronic variable stress in male adult rats.…”

Section: Discussionmentioning

confidence: 99%

Depressive-Like Behavior in Adolescents after Maternal Separation: Sex Differences, Controllability, and GABA

et al. 2012

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Exposure to adversity during development is an identified risk factor for depression later in life. In humans, early adversity accelerates the onset of depressive symptoms, which manifest during adolescence. Animal studies have used maternal separation as a model of early adversity to produce adult depressive-like behaviors, but have yet to examine these behaviors during adolescence. Moreover, the nature of depressive-like behaviors has not been well characterized in this model. Here, we used the triadic model of learned helplessness to understand controllability, helplessness, and motivational factors following maternal separation in male and female adolescent rats. We found sex-dependent changes in the effects of separation, with males demonstrating loss of controllability in an escapable shock condition, whereas females demonstrated motivational impairment in a no-shock condition. The effect, however, did not endure as adult females were no longer helpless. Reductions in parvalbumin, a GABAergic marker, in the prefrontal cortex of separated subjects relative to age-matched controls were evident and paralleled depressive-like behavior. Understanding the risk factors for depression, the nature of depressive-like behaviors, and their unique sex dependency may ultimately provide insight into improved treatments.

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Metabolic alterations in the visual pathway of retinitis pigmentosa rats: A longitudinal multimodal magnetic resonance imaging study with histopathological validation

et al. 2022

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Because retinitis pigmentosa (RP) has been shown to cause degenerative changes in the entire visual pathway, there is an urgent need to perform longitudinal assessments of RP‐induced degeneration and identify imaging protocols to detect this degeneration as early as possible. In this study, we assessed a transgenic rat model of RP by using complementary noninvasive magnetic resonance imaging techniques, namely, proton magnetic resonance spectroscopy (1H‐MRS), to investigate the metabolic changes in RP. Our study demonstrated decreased concentrations and ratios to creatine (Cr) of N‐acetylaspartate (NAA), glutamate (Glu), γ‐aminobutyric acid (GABA), and taurine (Tau), whereas myo‐inositol (Ins) and choline (Cho) were increased in the visual cortex of Royal College of Surgeons (RCS) rats compared with control rats (p < 0.05). Furthermore, with the progression of RP, the concentrations of NAA, Glu, GABA, and Tau, and the ratios of GABA/Cr and Tau/Cr significantly decreased over time, whereas the concentrations of Ins and Cho and the ratio of Ins/Cr significantly increased over time (p < 0.05). In addition, in RCS rats, NAA/Cr decreased significantly from 3 to 4 months postnatal (p < 0.001), and Cho/Cr increased significantly from 4 to 5 months postnatal (p = 0.005). Meanwhile, the 1H‐MRS indicators in 5‐month postnatal RCS rats could be confirmed by immunohistochemical staining. In conclusion, with the progression of RP, the metabolic alterations in the visual cortex indicated progressive reprogramming with the decrease of neurons and axons, accompanied by the proliferation of gliocytes.

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Neurodegenerative evidences during early onset of depression in CMS rats as detected by proton magnetic resonance spectroscopy at 7 T

Cited by 54 publications

References 46 publications

Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression

Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression

Depressive-Like Behavior in Adolescents after Maternal Separation: Sex Differences, Controllability, and GABA

Metabolic alterations in the visual pathway of retinitis pigmentosa rats: A longitudinal multimodal magnetic resonance imaging study with histopathological validation

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