2012
DOI: 10.1016/j.ccr.2012.05.012
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Neurodegenerative diseases and exposure to the environmental metals Mn, Pb, and Hg

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Cited by 83 publications
(48 citation statements)
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“…For instance, water resources have been contaminated by several trace elements such as Pb 2+ , when exposed to low concentrations of this metal [10]. Moreover, if humans are exposed to lead higher than 10 gL −1 [11], this contaminant could act as a powerful neurotoxic agent, leading to irreversible damage of the reproductive system along with hepatic and renal failure [10,12].…”
Section: Introductionmentioning
confidence: 99%
“…For instance, water resources have been contaminated by several trace elements such as Pb 2+ , when exposed to low concentrations of this metal [10]. Moreover, if humans are exposed to lead higher than 10 gL −1 [11], this contaminant could act as a powerful neurotoxic agent, leading to irreversible damage of the reproductive system along with hepatic and renal failure [10,12].…”
Section: Introductionmentioning
confidence: 99%
“…Attempts to control the spread of helminthiasis have relied largely on preventive mass chemotherapeutic treatment of school-age children, who are the highest risk group (Humphries et al, 2012; Figure 5). In recent years, after being neglected for several decades, other health-related disservices of soils have also begun to attract considerable attention, notably in connection with neurodegenerative diseases (Charlet et al, 2012) or the worrisome spread of antibiotic-resistant microbial pathogens (Wellington et al, 2013).…”
Section: Soil Functions or Services Or Both?mentioning
confidence: 99%
“…In this context, it has been previously demonstrated the importance of essential transition metals, such as copper, iron, and zinc, as modulators of the aggregation of some specific proteins that are directly linked to these diseases [6]. Moreover, it should be noted that the exposure to different toxic elements has been also proposed as an important etiological factor in the development of these disorders, such as aluminum in Alzheimer's disease [7] and manganese in Parkinson's disease [8].…”
Section: The Biological Importance Of Metalsmentioning
confidence: 95%