Neurodegenerative Diseases and Ageing

Walker, Lauren; McAleese, Kirsty E.; Erskine, Daniel; Attems, Johannes

doi:10.1007/978-981-13-3681-2_4

Cited by 13 publications

(9 citation statements)

References 161 publications

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“…It is a crucial risk factor for AD [6]. The consequences of aging associated with adverse changes in neuropathological features and cognition may lead to AD [12].…”

Section: Introductionmentioning

confidence: 99%

Air Pollution and Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Yung

2020

JAD

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Background: Ambient air pollution has been associated with Alzheimer’s disease (AD) in the elderly. However, its effects on AD have not been meta-analyzed comprehensively. Objective: We conducted a systematic review and meta-analysis to assess the associations between air pollution and AD incidence. Methods: We searched PubMed and Web of Science for indexed publications up to March 2020. Odds risk (OR) and confidence intervals (CI) were estimated for particulate matter (PM)10 (PM10), PM2.5, ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO). The subgroup analysis was conducted based on the pollution levels. Results: Nine studies were included in the meta-analysis and review. The OR per 10μg/m3 increase of PM2.5 was 1.95 (95% CI: 0.88–4.30). The corresponding values per 10μg/m3 increment of other pollutants were 1.03 (95% CI: 0.68–1.57) for O3, 1.00 (95% CI: 0.89–1.13) for NO2, and 0.95 (95% CI: 0.91–0.99) for PM10 (only one study), respectively. Overall OR of the five air pollutants above with AD was 1.32 (95% CI: 1.09–1.61), suggesting a positive association between ambient air pollution and AD incidence. The sub-analysis indicated that the OR (2.20) in heavily polluted regions was notably higher than that in lightly polluted regions (1.06). Although AD risk rate data related to SO2 or CO exposure are still limited, the epidemiologic and toxicological evidence indicated that higher concentration of SO2 or CO exposure increased risks of dementia, implying that SO2 or CO might have a potential impact on AD. Conclusion: Air pollution exposure may exacerbate AD development.

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“…It is a crucial risk factor for AD [6]. The consequences of aging associated with adverse changes in neuropathological features and cognition may lead to AD [12].…”

Section: Introductionmentioning

confidence: 99%

Air Pollution and Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Yung

2020

JAD

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“…Aging is marked by changes in the physiological functions of the brain. Brain aging is accompanied by learning and memory disorders [23], and the hippocampus plays a central role in the process of memory. The MWM test is one of the classic methods used to detect changes in ethology in learning and memory ability [24].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, the abundances of the remaining genera were significantly increased. Notably, Lactobacillus members are probiotics with anti-aging and anti-inflammatory effects [22,23]. Therefore, these results were not surprising.…”

Section: Fig 3 Effects Of Vap On the Levels Of Sod (A) Mda (B) Cat (C) And Gsh-px (D) In The Serum Of Aging Mice (N =mentioning

confidence: 96%

The anti-aging effect of velvet antler polypeptide is dependent on modulation of the gut microbiota and regulation of the PPARα/APOE4 pathway

Liu

Yang

et al. 2021

Journal of Integrative Neuroscience

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We investigated the anti-aging effects of velvet antler polypeptide on D-galactose (D-gal)-induced aging mice. D-gal-induced aging mice were established and randomly divided into five groups, the control, model, vitamin E (VE), velvet antler polypeptide low-dose and velvet antler polypeptide high-dose groups. The Morris water maze test was used to evaluate the learning and memory abilities of aging mice. Hippocampal neurons were observed via hematoxylineosin staining and transmission electron microscopy. Biochemical methods were used to detect the activities of superoxide dismutase, malonaldehyde and other enzymes and evaluate the influence of velvet antler polypeptide on the antioxidant capacity of aging mice. Using 16S rRNA gene sequencing and meristem technology, we assessed the effect of velvet antler polypeptide on aging mice's intestinal flora and fatty acid metabolism. The experimental results showed that velvet antler polypeptide could significantly improve aging mice's learning and cognitive abilities, increase the activities of superoxide dismutase, glutathione peroxidase, and catalase in the serum decrease the malonaldehyde content. Intestinal microecological analysis showed that velvet antler polypeptide could significantly increase the beneficial bacterial genus Lactobacillus abundance. Western blot analysis further demonstrated that velvet antler polypeptide could promote fatty acid metabolism by activating peroxisome proliferator-activated receptor α (PPARα) and upregulating the expression of the downstream enzymes carnitinepalmitoyl transferase-1 A and acyl-CoA oxidase 1 while downregulating that of apolipoprotein E4 (APOE4), thereby reducing fatty acid accumulation and increasing adenosine-triphosphate (ATP) production. Therefore, velvet antler polypeptide improves the intestinal microecology and activates the PPARα/APOE4 pathway to regulate fatty acid metabolism.

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“…Ageing is a significant risk factor associated with neurodegeneration. Various hallmarks of ageing, such as neuroinflammation, cellular senescence and mitochondrial dysfunction, correlate to the susceptibility of neurodegenerative diseases (Hou et al, 2019;Walker et al, 2019). Astrocyte dysfunction and protein mutations in the central nervous system (CNS) play critical roles in the onset, progression, and resolution of inflammation in neurodegeneration by chronic activation of innate immune responses (Amor et al, 2014;Hill, 2019).…”

Section: Introductionmentioning

confidence: 99%

Neurodegenerative diseases at the systems level

Sobti

Bayraktar²

2023

J Stud Res

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Neurodegenerative diseases (NDs) implicate protein aggregation and could impute network dysfunction, neuroinflammation and neuronal loss, among other factors. Changes attributed to a neurodegenerative brain -be it the accumulation of β-amyloid or the formation of neurofibrillary tangles -suggest cognitive, metabolic, and motor deficits. This literature review investigates the correlation between various neurodegenerative diseases at the systems level. Cognitive deficits primarily resulted from protein aggregates, while metabolic dysfunction linked to blood-brain barrier breakdown, damaged gut epithelium, and insulin resistance. Furthermore, motor impairments -seen as initial symptoms in various NDs -were defined by atrophy, autophagy, calcium dysregulation and neuronal reduction. Understanding the physicochemical and molecular changes that affect brain functioning on a systemic level can help provide much-needed information for developing diagnostic and therapeutic strategies. This literature review compiles existing research to link neurodegenerative diseases at a systems level. It investigates the effects of neurodegeneration on cognitive, metabolic and motor systems across various diseases, including Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Huntington's Disease (HD), Parkinson's Disease (PD) and prion diseases.

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Neurodegenerative Diseases and Ageing

Cited by 13 publications

References 161 publications

Air Pollution and Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Air Pollution and Alzheimer’s Disease: A Systematic Review and Meta-Analysis

The anti-aging effect of velvet antler polypeptide is dependent on modulation of the gut microbiota and regulation of the PPARα/APOE4 pathway

Neurodegenerative diseases at the systems level

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