Neurodegenerative and neurological disorders by small inhaled particles

Heusinkveld, Harm J.; Wahle, Tina; Campbell, Arezoo; Westerink, Remco H.S.; Tran, Lang; Johnston, Helinor Jane; Stone, Vicki; Cassee, Flemming R.; Schins, Roel P. F.

doi:10.1016/j.neuro.2016.07.007

Cited by 276 publications

(184 citation statements)

References 207 publications

(268 reference statements)

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“…The ability of inhaled particles to stimulate adverse effects in extrapulmonary sites has been reviewed previously [30], and likely to manifest due to (i) the translocation of particles from the lung to other target sites, or (ii) release of mediators (e.g., cytokines) from the lung which act systemically [30,31]. …”

Section: Introductionmentioning

confidence: 99%

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Dimakakou

Johnston

Streftaris

et al. 2018

IJERPH

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It has been hypothesised that environmental air pollution, especially airborne particles, is a risk factor for type 2 diabetes mellitus (T2DM) and neurodegenerative conditions. However, epidemiological evidence is inconsistent and has not been previously evaluated as part of a systematic review. Our objectives were to carry out a systematic review of the epidemiological evidence on the association between long-term exposure to ambient air pollution and T2DM and neurodegenerative diseases in adults and to identify if workplace exposures to particles are associated with an increased risk of T2DM and neurodegenerative diseases. Assessment of the quality of the evidence was carried out using the GRADE system, which considers the quality of the studies, consistency, directness, effect size, and publication bias. Available evidence indicates a consistent positive association between ambient air pollution and both T2DM and neurodegeneration risk, such as dementia and a general decline in cognition. However, corresponding evidence for workplace exposures are lacking. Further research is required to identify the link and mechanisms associated with particulate exposure and disease pathogenesis and to investigate the risks in occupational populations. Additional steps are needed to reduce air pollution levels and possibly also in the workplace environment to decrease the incidence of T2DM and cognitive decline.

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Section: Introductionmentioning

confidence: 99%

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Dimakakou

Johnston

Streftaris

et al. 2018

IJERPH

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“…При этом респираторная система рассматривается в качестве одной из основных портальных систем для поступления наноча-стиц в организм. Однако, помимо очевидного воздействия наноаэрозолей на респираторную и сердечнососудистую системы, частицы могут захватываться ольфакторным эпителием носовой полости и проникать в центральную нервную систему (ЦНС) в обход гематоэнцефалического барьера, где способны ускорять развитие нейродегенера-тивных заболеваний (Genter et al, 2012;Heusinkveld et al, 2016;Parmalee, Aschner, 2016;Patchin et al, 2016). Нейро паталогии, возникающие в результате воздействия на организм наноаэрозолей, трудно исследовать вследствие отсроченного характера их возникновения.…”

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Olfactory transport efficiency of the amorphous and crystalline manganese oxide nanoparticles

Romashchenko¹,

Petrovskii²,

Sharapova³

et al. 2017

Vestn. VOGiS

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The ability to deliver particulated xenobiotics and therapeutic drugs directly from the nasal cavity to the central nervous system, bypassing the hemato-encephalic barrier, determines a high importance of investigation of factors influencing this process. It was shown that the bioavailability of solid particles is influenced by their size and surface charge. At the same time, the impact of a crystal structure (crystalline/amorphous) has been poorly investigated. In this study, using sexually mature male C57BL/6J mice, we analyzed the efficiency of the nose-to-brain transport of crystalline and amorphous manganese oxide nanoparticles. T1-weighted magnetic resonance imaging (MRI) was used to evaluate the accumulation of manganese nanoparticles in olfactory bulb (OB) and olfactory epithelium (OE). So, it has been established that amorphous particles have higher accumulation rate in OE and OB in comparison with crystalline particles after their intranasal administration. The unequal ability of amorphous and crystalline particles to overcome the mucosal layer covering the OE may be one of the possible reasons for the different nose-to-brain transport efficiency of particulated matter. Indeed, the introduction of mucolytic (dithiothreitol) 20 minutes prior to intranasal particle application did not influence the accumulation of amorphous particles in OE and OB, but enhanced the efficiency of crystalline nanoparticle entry. Data on the different intake of amorphous and crystalline nanoparticles from the nasal cavity to the brain, as well as the evidence for the key role of the mucosal layer in differentiating the penetrating power of these particles will be useful in developing approaches to assessing air pollution and optimizing the methods of inhalation therapy.Key words: amorphous and crystalline nanoparticles; olfactory transport; mucosal layer; magnetic resonance imaging.Известно, что наноразмерные твердые аэрозоли способны посту-пать из носовой полости в мозг в обход гематоэнцефалического барьера. Необходимость исследования факторов, влияющих на назальный транспорт наночастиц, обусловлена тем, что таким образом в мозг могут проникать как ксенобиотики, так и терапев-тические препараты. Показано, что биодоступность твердых час-тиц определяет их размер и поверхностный заряд. Вместе с тем влияние структуры кристаллической решетки практически не исследовано. В данной работе, выполненной на половозрелых самцах мышей C57BL/6J, проанализирована эффективность поступ-ления в ольфакторный эпителий (ОЭ) и обонятельные луковицы (ОЛ) интраназально апплицированных наночастиц оксидов мар-ганца с аморфной и кристаллической структурой. Для оценки на-коп ления магнито-контрастных наночастиц марганца в ОЛ и ОЭ ис-пользовали Т1-взвешенную магнитно-резонансную томографию. Установлено, что аморфные частицы накапливаются в ОЭ и ОЛ в большей степени, чем кристаллические. Одной из причин различ-ного поступления в головной мозг интраназально введенных нанообъектов может быть неодинаковая способность аморфных и кристалических частиц преодол...

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“…PM with an aerodynamic diameter equal or less than 10 µm size (PM10) can gain easy access to the human body and affect different organ systems [4]. Dermatological (irritations, rashes, pigmentations) [5], ocular (corneal irritation, conjunctivitis) [6], respiratory (cough, allergic rhinitis, chronic obstruction of the airways) [7][8][9], cardiovascular (palpitations, atherosclerosis) [10,11], neurological (cerebrovascular accidents) [12][13][14][15][16], immunological (allergy, inflammation) [17,18], metabolic (diabetes mellitus, dyslipidaemia) diseases [19,20] and cancers [21,22] are associated with PM.…”

Section: Of 12mentioning

confidence: 99%

“…Dust particles collected from Jeddah region has been reported to contain heavy metals namely Chromium (Cr), Manganese (Mn), Cobalt (Co), Arsenic (As), Lead [14], Cadmium (Cd), Nickel (Ni), and Strontium (Sr) [27]. The Ingenuity Pathway Analysis (IPA) Knowledgebase (Qiagen, USA) was used to decipher the influence of these heavy metals on specific genes regulated in BM-MSCs.…”

Section: Ingenuity (Ipa) Pathway Analyses Of Heavy Metals In the Dustmentioning

confidence: 99%

Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches

Abu‐Elmagd

Alghamdi

Shamy

et al. 2017

Preprint

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Particulate matter (PM) contains heavy metals that affect various cellular functions and gene expression associated with an array of acute and chronic diseases, in humans. However, their specific effects on the stem cells remain unclear. Here, we report the effects of PM collected from Jeddah city on bone marrow mesenchymal stem cells (BM-MSCs) on proliferation, cell death, related gene expression and systems biological analysis aiming to understand the underlying mechanisms. Two different sizes (PM2.5-10) were tested in vitro at various concentrations (15 to 300 µg/ml) and durations (24 to 72 h). PMs induced cellular stress including membrane damage, shrinkage and death. Lower concentrations of PM2.5 increased BM-MSCs proliferation, while higher concentrations decreased it. PM10 decreased BM-MSCs proliferation in a concentration-dependant manner. The XRay Fluorescence spectrometric analysis showed that PM contains high levels of heavy metals. Ingenuity Pathway Analysis (IPA) and hierarchical clustering analyses showed that heavy metals were associated with signalling pathways involving cell stress/death, cancer and chronic diseases. qRT-PCR results showed differential regulation of the apoptosis genes (BCL2, BAX); upregulation of inflammation associated genes (TNF-α and IL-6) and downregulation of cell cycle regulation gene (P53). We conclude that PM could affect different cellular functions and predispose to debilitating diseases.

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Neurodegenerative and neurological disorders by small inhaled particles

Cited by 276 publications

References 207 publications

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Olfactory transport efficiency of the amorphous and crystalline manganese oxide nanoparticles

Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches

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