Neurocysticercosis is still prevalent in Mexico

Fleury, Agnès; Sciutto, Edda; Larralde, Carlos

doi:10.1590/s0036-36342012000600012

Cited by 19 publications

(13 citation statements)

References 27 publications

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“…Neurocysticercosis (NCC), the most common parasitic disease of the central nervous system (CNS), is still a cause of unacceptable morbidity and mortality in endemic areas . It is also an emerging public health problem in high‐income countries .…”

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confidence: 99%

New diagnostic criteria for neurocysticercosis: Reliability and validity

Carpio

Fleury

Romo

et al. 2016

Annals of Neurology

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ObjectiveThe diagnosis of neurocysticercosis (NCC) remains problematic because of the heterogeneity of its clinical, immunological, and imaging characteristics. Our aim was to develop and assess a new set of diagnostic criteria for NCC, which might allow for the accurate detection of, and differentiation between, parenchymal and extraparenchymal disease.MethodsA group of Latin American NCC experts developed by consensus a new set of diagnostic criteria for NCC. A multicenter, retrospective study was then conducted to validate it. The reference standard for diagnosis of active NCC was the disappearance or reduction of cysts after anthelmintic treatment. In total, three pairs of independent neurologists blinded to the diagnosis evaluated 93 cases (with NCC) and 93 controls (without NCC) using the new diagnostic criteria. Mixed‐effects logistic regression models were used to estimate sensitivity and specificity.ResultsInter‐rater reliability (kappa) of diagnosis among evaluators was 0.60. For diagnosis of NCC versus no NCC, the new criteria had a sensitivity of 93.2% and specificity of 81.4%. For parenchymal NCC, the new criteria had a sensitivity of 89.8% and specificity of 80.7% and for extraparenchymal NCC, the new criteria had a sensitivity of 65.9% and specificity of 94.9%.InterpretationThese criteria have acceptable reliability and validity and could be a new tool for clinicians and researchers. An advantage of the new criteria is that they consider parasite location (ie, parenchymal or extraparenchymal), which is an important factor determining the clinical, immunological, and radiological presentation of the disease, and importantly, its treatment and prognosis. Ann Neurol 2016;80:434–442

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confidence: 99%

New diagnostic criteria for neurocysticercosis: Reliability and validity

Carpio

Fleury

Romo

et al. 2016

Annals of Neurology

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“…Both chronic and acute liver complications are common causes of mortality worldwide (Kandiah et al 2016). Furthermore, parasite infections are a public health problem in developing countries and they constitute an emerging concern even in developed nations (Fleury et al 2012, Fabiani & Bruschi 2013, Chomicz et al 2016). Since liver disease and parasite infections are prevalent conditions in many countries, their comorbidity is highly likely.…”

Section: Discussionmentioning

confidence: 99%

A non-hepatotropic parasite infection increases mortality in the acetaminophen-induced acute liver failure murine model: possible roles for IL-5 and IL-6

León-Nava

Álvarez-Delgado

Donis-Maturano

et al. 2016

Mem. Inst. Oswaldo Cruz

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We evaluated the effects of a non-hepatotropic parasite infection (Taenia crassiceps) on the outcome of acetaminophen-induced acute liver failure in mice. Uninfected and T. crassiceps infected mice orally received either 300 mg/kg acetaminophen or water as vehicle (n = 5 per group). Survival analysis, hepatocyte necrosis, alanine aminotransferase (ALT) levels, CYP2E1 protein, interleukin (IL-) 5, and IL-6 were assessed for all groups. All infected mice died within 16 h after exposure to acetaminophen (Tc+APAP group), whereas only one-third of uninfected animals exposed to acetaminophen (APAP group) died. Uninfected (Control group) and infected (Tc group) mice that received the vehicle showed no liver damage. Tc+APAP mice exhibited massive liver necrosis characterised by marked balloning degeneration of hepatocytes and higher serum ALT compared to Control, Tc, and APAP animals. Liver tissue from Tc+APAP mice also displayed increased expression of CYP2E1 protein and higher mRNA and protein levels of IL-5 and IL-6 compared to the other groups. These findings suggest that non-hepatotropic parasite infections may increase mortality following acute liver failure by promoting hepatocyte necrosis via IL-5 and IL-6-dependent CYP2E1 overproduction. This study identifies new potential risk factors associated with severe acute liver failure in patients.

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“…Studies from a slum in India revealed that 25.5% of people in the studied sample who had active epilepsy had antibodies to T. solium (Singh et al, 2012). Cysticercosis in pigs may reach 30% prevalence or more in some countries where pigs are allowed to roam and human defecation is done in the open (Carrique-Mas et al, 2001;Fleury et al, 2012;Flisser et al, 2003). Even with low human taeniasis in the order of 1-2%, the prevalence of cysticercosis in pigs can be high.…”

Section: Burden Of Diseasementioning

confidence: 92%