Neurocysticercosis and Other CNS Helminthic Infections

Tanabe, Melinda B.; Schilling, Matthew; White, A. Clinton

doi:10.1007/978-3-030-56084-3_11

Cited by 2 publications

(4 citation statements)

References 118 publications

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“…For example, a previous otherwise treatable roundworm infection caused by the ingestion of Trichinella larvae becomes severe trichinosis in cases of heavy infestation ( 38 , 39 ). In addition, several reports show that vital organ complications such as myocarditis, encephalitis, or meningitis, caused by foodborne parasitic diseases increase in-hospital mortality, something that we observed in our results ( 40 , 41 ).…”

Section: Discussionsupporting

confidence: 85%

Waterborne diseases and ethnic-related disparities: A 10 years nationwide mortality and burden of disease analysis from Ecuador

Ortíz-Prado

Simbaña-Rivera

Cevallos

et al. 2022

Front. Public Health

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BackgroundDespite worldwide progress in terms of clean water supply, sanitation, and hygiene knowledge, some middle and most of low-income countries are still experiencing many diseases transmitted using unsafe water and the lack of sanitation.MethodsTo understand the impact of all waterborne diseases (WBD) registered in Ecuador. We performed a population-based analysis of all cases and deaths due to WBD in Ecuador based on the national public databases of hospital discharges as a proxy of incidence, in-hospital mortality, and countrywide general mortality rates from 2011 to 2020.ResultsIn Ecuador, mestizos (mixed European and Indigenous American ancestry) had the greatest morbidity rate (141/100,000), followed by indigenous (63/100,000) and self-determined white patients (21/100,000). However, in terms of mortality, indigenous population have the greatest risk and rates, having a 790% additional mortality rate (2.6/100,000) than the reference group (self-determined white populations) at 0.29/100,000. The burden of disease analysis demonstrated that indigenous had the highest burden of disease caused by WBD with 964 YLL per every 100,000 people while mestizos have 360 YYL per 100,000 and self-determined white Ecuadorians have 109 YYL per 100,000.ConclusionsIn Ecuador, waterborne diseases (WBD) are still a major public health problem. We found that indigenous population had higher probability of getting sick and die due to WBD than the rest of the ethnic groups in Ecuador. We also found that younger children and the elderly are more likely to be admitted to the hospital due to a WBD. These epidemiological trends are probably associated with the lower life expectancy found among Indigenous than among the rest of the ethnic groups, who die at least, 39 years earlier than the self-determined white populations, 28 years earlier than Afro-Ecuadorians and 12 years earlier than the mestizos.

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Section: Discussionsupporting

confidence: 85%

Waterborne diseases and ethnic-related disparities: A 10 years nationwide mortality and burden of disease analysis from Ecuador

Ortíz-Prado

Simbaña-Rivera

Cevallos

et al. 2022

Front. Public Health

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“…Neurocysticercosis (NCC) is a central nervous system (CNS) infection in humans caused by larvae of the parasitic pork tapeworm, Taenia solium. 1 According to the World Health Organization (2021), an estimated 2.56 to 8.30 million people globally have NCC. 2 After lodging and developing in the human CNS, T. solium larvae usually remain alive for a few years, during which time the disease is usually asymptomatic.…”

Section: Prevalence and Etiology Of Neurocysticercosismentioning

confidence: 99%

“…Neurocysticercosis (NCC) is a central nervous system (CNS) infection in humans caused by larvae of the parasitic pork tapeworm, Taenia solium 1 . According to the World Health Organization (2021), an estimated 2.56 to 8.30 million people globally have NCC.…”

Section: Prevalence and Etiology Of Neurocysticercosismentioning

confidence: 99%

“…2 After lodging and developing in the human CNS, T. solium larvae usually remain alive for a few years, during which time the disease is usually asymptomatic. 1 Estimates of the proportion of people with NCC who are symptomatic are challenging to come by, as asymptomatic patients are generally unlikely to undergo brain scans or serological tests that would reveal an NCC diagnosis. 3 A few studies, have, however, attempted to determine this proportion in endemic communities, and estimates of symptomatic NCC range from 17% to 62%.…”

Section: Prevalence and Etiology Of Neurocysticercosismentioning

confidence: 99%

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What Causes Seizures in Neurocysticercosis?

et al. 2022

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Neurocysticercosis (NCC) is the most prevalent parasitic infection of the central nervous system. It is caused by the presence of larvae of the cestode Taenia solium in the brain. The most common symptom of NCC is seizures, and it is widely considered the world’s leading cause of preventable epilepsy. Despite the prevalence and impact of NCC, a thorough, mechanistic understanding of seizure generation is still lacking. In this review, we address the question “What causes seizures in NCC?” by summarizing and discussing the major theories that seek to explain the seizurogenic and epileptogenic processes in this disorder. In addition, we highlight the potential for recent advances in disease modeling to help accelerate progress in this area.

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Neurocysticercosis and Other CNS Helminthic Infections

Cited by 2 publications

References 118 publications

Waterborne diseases and ethnic-related disparities: A 10 years nationwide mortality and burden of disease analysis from Ecuador

Waterborne diseases and ethnic-related disparities: A 10 years nationwide mortality and burden of disease analysis from Ecuador

What Causes Seizures in Neurocysticercosis?

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