2016
DOI: 10.1055/s-0035-1570069
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Neurocutaneous Syndromes as Embryonic Neurocristopathies

Abstract: Most neurocutaneous syndromes are somatic genetic mutations involving neural crest derivatives, hence are neurocristopathies. Neural crest is best understood in the context of ontogenetic and phylogenetic development and of the history of the evolution of the concepts surrounding its discovery and interpretation. The neural crest is an embryonic layer of cells at the margins of the neural plate, first distinguished at gastrulation. As the embryonic neural folds close dorsally to form the neural tube, these neu… Show more

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