Neurocognitive Profile of the Post-COVID Condition in Adults in Catalonia—A Mixed Method Prospective Cohort and Nested Case–Control Study: Study Protocol

Dacosta-Aguayo, Rosalía; Lamonja-Vicente, Noemí; Chacón, Carla; Carrasco-Ribelles, Lucía A.; Montero-Alía, Pilar; Costa-Garrido, Anna; García-Sierra, Rosa; López-Lifante, Victor M; Moreno-Gabriel, Eduard; Massanella, Marta; Puig, Josep; Muñoz-Moreno, Jose A.; Mateu, Lourdes; Prats, Anna; Rodríguez, Carmina; Mataró, María; Prado, Julia G.; Martínez-Cáceres, Eva; Violán, Concepción; Torán-Monserrat, Pere

doi:10.3390/vaccines10060849

Cited by 4 publications

(1 citation statement)

References 84 publications

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“…The final regression analysis model demonstrated that elevated levels of anxiety and depression, the existence of PTSD-like symptoms, and the presence of COVID-related stigma at T1 are indicative of the likelihood of experiencing PTSD-like symptoms in the subsequent 4-month follow-up assessment. Previous research also showed that COVID-19 exacerbates psychological conditions such as anxiety and depression (e.g., Dacosta-Aguayo et al, 2022), and those, in turn, increase the likelihood of developing PTSD and similar conditions. Furthermore, as a consequence of labeling and harmful stereotyping due to the novelty, uncertainty, and person-to-person transmission of the virus (i.e., stigma), one may experience mental health problems, including extreme stress (Kang et al, 2021).…”

Section: Discussionmentioning

confidence: 94%

Factors associated with prolonged COVID-related PTSD-like symptoms among adults diagnosed with mild COVID-19 in Poland

Elkayam,

Łojek,

Sękowski

et al. 2024

Front. Psychol.

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COVID-19 has been considered a possible cause of post-traumatic stress disorder (PTSD) or similar conditions. However, what specific disease symptoms may contribute most to prolonged PTSD-like symptoms in COVID-19 survivors is unclear. The study aimed to present the factor structure of COVID-19 symptoms and identify which symptoms of COVID-19 best explain the subsequent presence of PTSD-like symptoms in mild COVID-19 survivors. COVID-positive adults (n = 341) completed online self-report scales at the baseline assessment (T1) and after approximately 4 months (T2), including The Patient Health Questionnaire Anxiety-Depression Scale; The Scale of Psychosocial Experience Related to COVID-19, The Primary Care PTSD Screen for DSM-5; and self-designed questionnaires evaluating the severity of COVID-related medical and neurocognitive symptoms and pre-pandemic variables. Exploratory factor analysis revealed five factors of COVID-19 symptoms: flu-like, respiratory, cold, neurological, and neurocognitive. Hierarchical logistic regression showed that besides selected control variables (anxiety and depression, presence of PTSD-like symptoms, COVID-related stigma in T1), neurocognitive symptoms of COVID-19 in T1 but not other symptoms of the disease were a significant predictor of the presence of PTSD-like symptom in T2. Findings suggest a need for a comprehensive neurocognitive assessment of people diagnosed with COVID-19 and prompt interventions targeting the prevention of potential risks for long-term PTSD-like states at the community level.

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Section: Discussionmentioning

confidence: 94%

Factors associated with prolonged COVID-related PTSD-like symptoms among adults diagnosed with mild COVID-19 in Poland

Elkayam,

Łojek,

Sękowski

et al. 2024

Front. Psychol.

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Reduced Cortical Thickness Correlates of Cognitive Dysfunction in Post-COVID-19 Condition: Insights from a Long-Term Follow-up

Dacosta-Aguayo,

Puig,

Lamonja-Vicente

et al. 2024

AJNR Am J Neuroradiol

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Long COVID: cognitive, balance, and retina manifestations

Carmona-Cervelló,

León-Gómez,

Dacosta-Aguayo

et al. 2024

Front. Med.

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BackgroundThe neurological symptoms of Long COVID (LC) and the impact of neuropsychological manifestations on people’s daily lives have been extensively described. Although a large body of literature describes symptoms, validating this with objective measures is important. This study aims to identify and describe the effects of Long COVID on cognition, balance, and the retinal fundus, and determine whether the duration of symptoms influences cognitive impairment.MethodsThis cross-sectional study involved LC volunteers with cognitive complaint from public health centers in northern Barcelona who participated between January 2022 and March 2023. This study collected sociodemographic characteristics, information on substance use, comorbidities, and clinical data related to COVID-19. We measured five cognitive domains using a battery of neuropsychological tests. Balance was assessed through posturography and retinal vascular involvement by retinography.ResultsA total of 166 people with LC and cognitive complaints participated, 80.72% were women and mean age was 49.28 ± 8.39 years. The most common self-reported symptoms were concentration and memory deficit (98.80%), brain fog (82.53%) and insomnia (71.17%). The 68.67% presented cognitive deficit in at least one domain, with executive functions being the most frequent (43.98%). The 51.52% of the participants exhibited a dysfunctional pattern in balance, and 9.2% showed some alteration in the retina. There were no statistically significant differences between cognitive impairment and symptom duration.ConclusionOur findings contribute to a more comprehensive understanding of the pathology associated with Long COVID. They highlight the diversity of self-reported symptoms, the presence of abnormal balance patterns, and some cognitive impairment. These findings underscore the necessity of addressing the clinical management of this condition in primary care through follow-up and the pursuit of multidisciplinary and comprehensive treatment.

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Neurocognitive Profile of the Post-COVID Condition in Adults in Catalonia—A Mixed Method Prospective Cohort and Nested Case–Control Study: Study Protocol

Cited by 4 publications

References 84 publications

Factors associated with prolonged COVID-related PTSD-like symptoms among adults diagnosed with mild COVID-19 in Poland

Factors associated with prolonged COVID-related PTSD-like symptoms among adults diagnosed with mild COVID-19 in Poland

Reduced Cortical Thickness Correlates of Cognitive Dysfunction in Post-COVID-19 Condition: Insights from a Long-Term Follow-up

Long COVID: cognitive, balance, and retina manifestations

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