Neurocognitive Predictors of Understanding of Intentions in Parkinson Disease

Košutzká, Zuzana; Kŕaĺová, Mária; Kušnírová, Alice; Pápayová, Mariana; Valkovič, Peter; Cséfalvay, Zsolt

doi:10.1177/0891988719841727

Cited by 11 publications

(12 citation statements)

References 47 publications

(52 reference statements)

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“…Thus, an expected effect of LEDD (moderating effect analysis) was found on the relationship between Cognitive ToM and attention and working memory domain. This result may be in line with the involvement of the dopaminergic system in Cognitive ToM because improvements in performance on ToM tasks as a function of medication in PD were found (Del Prete et al, 2020;Foley et al, 2019;Kosutzka et al, 2019;Roca et al, 2010). These findings strengthen the idea that dopaminergic treatment may influence social cognition by its impact on executive functions.…”

Section: Neuropsychological Correlates Of Tomsupporting

confidence: 81%

“…Sensitivity analysis omitting the study of Kosutzka et al (2019) or Nobis et al (2017) revealed that without these studies, these results became not significant.…”

Section: Affective and Cognitive Theory Of Mind In Pdmentioning

confidence: 94%

“…The leave-one-out sensitivity analyses revealed that the omission of the study by Kosutzka et al (2019) Poorer performance on Affective ToM tasks were related to lower educational level (k = 5, r = 0.15, p = .032; Figure 8). The heterogeneity was absent, Q(4) = 3.89, p = .421, I 2 = 0.00 but Egger's regression test indicated significant publication bias ( p = .043) and the trim and fill method suggested that at least three effect sizes with positive results (positive r values) would be necessary to make the funnel symmetrical (Table 3).…”

Section: Sociodemographic Correlatesmentioning

confidence: 99%

“…Similarly, the underlying cognitive variables that explain ToM performance in PD are still unclear. Some reports relate executive and working memory dysfunctions in PD to ToM performance (Costa et al, 2013;Eddy et al, 2013;Enrici et al, 2017;Foley et al, 2019;Kosutzka et al, 2019;Monetta et al, 2009;Saltzman et al, 2000), whereas other studies failed to confirm these relationships (Euteneuer et al, 2009;Schmidt et al, 2017). Specifically, poorer ToM performance were linked with executive dysfunctions in working memory (Enrici et al, 2017;Kosutzka et al, 2019), cognitive flexibility (Díez-Cirarda et al, 2015;Kosutzka et al, 2019), and inhibition (Foley et al, 2019).…”

mentioning

confidence: 99%

“…Recently, social cognition impairments have also been reported in PD (Coundouris et al, 2020; Palmeri et al, 2017). Some studies reported a significant association between ToM deficits and PD duration, stage of illness (Kosutzka et al, 2019; Nobis et al, 2017; Romosan et al, 2019; Schmidt et al, 2017; Xi et al, 2015; Yu et al, 2018), or medication (Foley et al, 2019; Kosutzka et al, 2019). Yet, failure to confirm any relationship between ToM dysfunction and clinical variables (including the severity of motor symptoms) in PD has been reported (Bodden et al, 2010b; Enrici et al, 2015, 2017; Giguère-Rancourt et al, 2021; Monetta et al, 2009; Pell et al, 2014; Santangelo et al, 2012; Seubert-Ravelo et al, 2021; Tsuruya et al, 2011), probably explained by different weights of some cognitive domains or neuropsychiatric states.…”

mentioning

confidence: 99%

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Neuropsychological, neuropsychiatric, and clinical correlates of affective and cognitive theory of mind in Parkinson’s disease: A meta-analysis.

Maggi¹,

Muñoz²,

Obeso³

et al. 2022

Neuropsychology

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Objective: Theory of mind (ToM) is the ability to infer others’ mental (Cognitive) and emotional (Affective) states, both being impaired in Parkinson’s disease (PD). However, the clinical, neuropsychological, and neuropsychiatric features underlying Affective and Cognitive ToM deficits in PD are unclear. Therefore, we performed a meta-analytic study to test whether PD demographical, clinical, neuropsychological, or neuropsychiatric changes related differently to both ToM processes. Method: A systematic literature search was performed up to January 2022, including a total of 31 studies following our search terms. Data from each study were obtained from demographic (age, education), clinical (disease duration, Hoehn & Yahr staging system, Unified Parkinson’s Disease Rating Scale-III, levodopa equivalent daily dose), neuropsychological (global cognitive functioning, memory subdomains, executive functions subdomains, processing speed/complex attention/working memory, visuospatial and constructional abilities, and language), and neuropsychiatric (depression, apathy, anxiety) variables. Results: Affective ToM impairment in PD was related to lower educational level and global cognition, deficits of generativity, decision making, attention/working memory, and language. Conversely, Cognitive ToM deficits were associated with advanced age, poorer global cognition, executive dysfunctions, and language impairments. Medication moderated the relationship between attention/working memory and Cognitive ToM, whereas age moderated the association of Affective ToM with language. No significant associations were found between ToM deficits and patients’ neuropsychiatric or clinical states. Conclusions: These findings clarify the neuropsychological and clinical features that explain ToM deficits in PD. Possibly, our results suggest the need to explore the complex neural networks involving frontostriatal and temporoparietal circuits behind changes in social cognition in PD.

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Section: Neuropsychological Correlates Of Tomsupporting

confidence: 81%

“…Sensitivity analysis omitting the study of Kosutzka et al (2019) or Nobis et al (2017) revealed that without these studies, these results became not significant.…”

Section: Affective and Cognitive Theory Of Mind In Pdmentioning

confidence: 94%

Section: Sociodemographic Correlatesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Neuropsychological, neuropsychiatric, and clinical correlates of affective and cognitive theory of mind in Parkinson’s disease: A meta-analysis.

Maggi¹,

Muñoz²,

Obeso³

et al. 2022

Neuropsychology

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Social Cognition in Parkinson's Disease after Focused Ultrasound Subthalamotomy: A Controlled Study

Guida,

Martínez‐Fernández,

Máñez‐Miró

et al. 2024

Movement Disorders

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Social cognition (SC) encompasses a set of cognitive functions that enable individuals to understand and respond appropriately to social interactions. Although focused ultrasound subthalamotomy (FUS‐STN) effectively treats Parkinson's disease (PD) clinical motor features, its impact and safety on cognitive‐behavioral interactions/interpersonal awareness are unknown. This study investigated the effects of unilateral FUS‐STN on facial emotion recognition (FER) and affective and cognitive theory of mind (ToM) in PD patients from a randomized sham‐controlled trial (NCT03454425). Subjects performed SC evaluation before and 4 months after the procedure while still under blind assessment conditions. The SC assessment included the Karolinska Directed Emotional Faces task for FER, the Reading the Mind in the Eyes (RME) test for affective ToM, and The Theory of Mind Picture Stories Task (ToM PST) (order, questions, and total score) for cognitive ToM. The active treatment group showed anecdotal‐to‐moderate evidence of no worsening in SC after FUS‐STN. Anecdotal evidence for an improvement was recognized in the SC score changes, from baseline to post‐treatment, for the active treatment group compared with sham for the RME, ToM PST order, ToM PST total, FER total, and recognition of fear, disgust, and anger. This study provides the first evidence that unilateral FUS‐STN does not impair social cognitive abilities, indicating that it can be considered a safe treatment approach for this domain in PD patients. Furthermore, the results suggest FUS‐STN may even lead to some improvement in social cognitive outcomes, which should be considered as a preliminary finding requiring further investigation with larger samples sizes. © 2024 International Parkinson and Movement Disorder Society.

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Measuring mentalizing: A comparison of scoring methods for the hinting task

Klein

Springfield

Bass

et al. 2020

Int J Methods Psych Res

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ObjectiveThe Social Cognition Psychometric Evaluation (SCOPE) study supported the utility and practicality of the Hinting task as a measure of social cognition/mentalizing in clinical trials, specifically with the SCOPE authors' stringent scoring system. However, it remains unclear whether the SCOPE scoring system is necessary for the task to be judged as psychometrically sound.MethodIndependent raters rescored data from the three phases of SCOPE using the Hinting task's original scoring criteria. Psychometric properties of the task when scored with the original criteria versus more stringent SCOPE criteria were compared in a large sample of individuals with chronic schizophrenia (n = 397) and matched controls (n = 300) as well as a smaller sample of individuals with early psychosis (n = 38) and controls (n = 39).ResultsIn both samples, SCOPE criteria resulted in lowered average scores and reduced ceiling effects. Further, revised scoring resulted in strengthened relationships between the hinting task and outcome measures in the chronic sample, and better differentiated early psychosis patients from controls. Conversely, test‐retest reliability and internal consistency estimates were not improved using revised scoring and remained suboptimal, particularly for healthy controls.ConclusionOverall, SCOPE scoring criteria improved some psychometric properties and clinical utility, suggesting that these criteria should be considered for implementation.

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Neurocognitive Predictors of Understanding of Intentions in Parkinson Disease

Cited by 11 publications

References 47 publications

Neuropsychological, neuropsychiatric, and clinical correlates of affective and cognitive theory of mind in Parkinson’s disease: A meta-analysis.

Neuropsychological, neuropsychiatric, and clinical correlates of affective and cognitive theory of mind in Parkinson’s disease: A meta-analysis.

Social Cognition in Parkinson's Disease after Focused Ultrasound Subthalamotomy: A Controlled Study

Measuring mentalizing: A comparison of scoring methods for the hinting task

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