Neurocognitive Performance is Not Degraded After Stellate Ganglion Block Treatment for Post-Traumatic Stress Disorder: A Case Series

Mulvaney, Sean W.; Lynch, James H.; Leeuw, Jason De; Schroeder, Melanie; Kane, Shawn F.

doi:10.7205/milmed-d-14-00504

Cited by 11 publications

(18 citation statements)

References 21 publications

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“…The secondary literature search identified an additional 7 publications resulting in 32 publications included in the review. These comprised 15 case reports and case series, 1 systematic case review, 2 publications related to a single published RCT, and 14 nonsystematic reviews, opinions, guidelines, commentaries, books, and book chapters . The systematic search results are shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…A further case series in 2015 among military service members diagnosed with PTSD evaluated effects of SGB on measures of neurocognitive performance, including memory and reaction time, and found no impairment in these functional categories with treatment. The authors concluded these findings constituted a potential advantage of SGB, particularly for military service members who might return to combat . Bringing further synthesis to the expanding literature base, Lipov and Ritchie published a new review, and Lipov published an extensive book chapter discussing the potential for SGB to serve as an alternative treatment option for combat‐related PTSD …”

Section: Resultsmentioning

confidence: 99%

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Stellate Ganglion Block in the Treatment of Post‐traumatic Stress Disorder: A Review of Historical and Recent Literature

Summers

Nevin

2016

Pain Practice

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Concerns over the rising prevalence of post-traumatic stress disorder (PTSD), particularly among military service members returning from combat, and over barriers that hinder individuals from seeking out or adhering to standard therapies have contributed to interest in alternative therapies for the disorder. A novel alternative therapy for PTSD-stellate ganglion block (SGB)-may be considered lacking in formal evidence of efficacy despite having shown considerable promise. This review of the recent and historical literature related to SGB finds evidence of substantial beneficial psychiatric effects and substantiates that this fast-acting, somatic treatment may provide positive results for patients with PTSD and may reduce barriers to therapy, particularly among military populations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Stellate Ganglion Block in the Treatment of Post‐traumatic Stress Disorder: A Review of Historical and Recent Literature

Summers

Nevin

2016

Pain Practice

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“…The pathogenesis of chronic ulcerative colitis is complex. However, recent studies have shown that this disease and immune dysfunction are correlated[ 41 , 42 ], and that the stellate ganglion block technique plays a very important role in regulating immune function[ 43 - 46 ]. Therefore, the main aim of this study was to investigate the efficacy and safety of the stellate ganglion block technique in the treatment of chronic ulcerative colitis.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of stellate ganglion block in chronic ulcerative colitis

Zhao¹,

Yang²,

Sun³

et al. 2017

WJG

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AIMTo investigate the efficacy and safety of stellate ganglion block for the treatment of patients with chronic ulcerative colitis.METHODSA total of 120 randomly selected patients with chronic ulcerative colitis treated in Cangzhou Central Hospital from January 2014 to January 2016 were included in this study. These patients were divided into two groups: control group (n = 30), patients received oral sulfasalazine treatment; experimental group (n = 90), patients received stellate ganglion block treatment. Clinical symptoms and disease activity in these two groups were compared before and after treatment using endoscopy. Blood was collected from patients on day 0, 10, 20 and 30 after treatment. Enzyme-linked immunosorbent assay was performed to determine interleukin-8 (IL-8) level. The changes in IL-8 level post-treatment in the two groups were compared using repeated measures analysis of variance.RESULTSAfter treatment, clinical symptoms and disease activity were shown to be alleviated by endoscopy in both the control and experimental groups. However, patients in the control group did not have obvious abdominal pain relief. In addition, the degree of pain relief in the experimental group was statistically better than that in the control group (P < 0.05). Ten days after treatment, IL-8 level was found to be significantly lower in the experimental group than in the control group, and the difference was statistically significant (P < 0.05). In addition, adverse events were significantly higher in the control group than in the experimental group, and the difference was statistically significant (χ2 = 33.215, P = 0.000).CONCLUSIONThe application of stellate ganglion block effectively improves treatment efficacy in chronic ulcerative colitis, relieves clinical symptoms in patients, and reduces the level of inflammatory factors. Furthermore, this approach also had a positive impact on the disease to a certain extent.

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“…4 Specific for this indication, the SGB procedure has been evaluated in 14 peer-reviewed publications since 1990, including a multicenter randomized clinical trial in 2019, supporting this modality's safety and effectiveness in the successful treatment of PTSD symptoms across a variety of patient demographics and trauma etiologies. [4][5][6][7][8][9][10][11][12][13][14][15][16][17] Though 1 small trial showed the effects of SGB were equivalent to a sham injection, it should be noted that the SGB arm in this study still demonstrated an 8-point reduction in PTSD checklist (PCL) scores at 1 month. 16 While many of these early studies are level 2 or 3 evidence, a collective examination of all studies demonstrates consistent findings with respect to safety, onset of relief, magnitude of effect, and success rates.…”

Section: Original Researchmentioning

confidence: 98%

Behavioral Health Clinicians Endorse Stellate Ganglion Block as a Valuable Intervention in the Treatment of Trauma-Related Disorders

Lynch

Muench²,

Okiishi

et al. 2021

Journal of Investigative Medicine

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The stellate ganglion block (SGB) procedure has been used successfully for over 10 years to treat post-traumatic stress symptoms in thousands of US military service members, civilians, and veterans in select hospitals in Europe and North America. Primarily through targeting the autonomic nervous system, the SGB procedure serves as an invaluable adjunct to trauma-focused psychotherapy. Without published best practices for emerging therapies, clinicians are left on their own to determine how best to apply new treatments to their patient populations. The aim of this qualitative research was to compile attitudes and recommendations from therapists with expertise in using SGB for treating symptoms of post-traumatic stress disorder, so that their experiences could be disseminated widely to clinicians without SGB expertise. An 18-item survey was developed and distributed electronically to a group of behavioral health professionals of various specialties between May and June 2020. Of surveyed behavioral health clinicians with personal experience incorporating SGB into their trauma-focused psychotherapy, 95% of respondents would recommend SGB to a colleague as a useful tool for the treatment of trauma-related disorders. SGB was rated at least as useful as the most valuable interventions listed in the American Psychological Association Clinical Practice Guideline for the Treatment of Post-traumatic Stress Disorder with 100% of respondents characterizing SGB as ‘Very Beneficial’ or ‘Somewhat Beneficial’, and 0 respondents characterizing SGB as ‘Not Helpful’ or ‘Harmful’. Given the feedback from this study, behavioral health providers should consider using SGB in conjunction with standard trauma-focused care.

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Neurocognitive Performance is Not Degraded After Stellate Ganglion Block Treatment for Post-Traumatic Stress Disorder: A Case Series

Abstract: In this case series of 11 patients, SGB effectively treated PTSD symptoms and did not impair reaction time, memory, or concentration. Therefore, SGB should be considered as a viable treatment option for personnel with PTSD symptoms who will be placed in demanding conditions such as combat.

Cited by 11 publications

References 21 publications

Stellate Ganglion Block in the Treatment of Post‐traumatic Stress Disorder: A Review of Historical and Recent Literature

Stellate Ganglion Block in the Treatment of Post‐traumatic Stress Disorder: A Review of Historical and Recent Literature

Efficacy and safety of stellate ganglion block in chronic ulcerative colitis

Behavioral Health Clinicians Endorse Stellate Ganglion Block as a Valuable Intervention in the Treatment of Trauma-Related Disorders

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