Neurocognitive performance in patients with depression compared to healthy controls: Association of clinical variables and remission state

Grützner, Thea Marianne; Sharma, Anuradha; Listunova, Lena; Bartolovic, Marina; Weisbrod, Matthias; Roesch-Ely, Daniela

doi:10.1016/j.psychres.2018.11.047

Cited by 7 publications

(3 citation statements)

References 56 publications

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“…In light of the heterogeneity in cognitive profiles observed in mood disorders, several studies in recent years have looked to clinical, sociodemographic and other individual characteristics as potential causes of cognitive variability in both BD and MDD (Ehrminger et al, 2019;Grützner et al, 2019;Solé et al, 2016;Van Rheenen et al, 2019). One important variable to emerge from these studies was cognitive reserve (CR), which consists of the brain's ability to attenuate cognitive impairments caused by aging or neuropathology (Stern et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The effects of cognitive reserve and depressive symptoms on cognitive performance in major depression and bipolar disorder

Ponsoni

Branco

Cotrena

et al. 2020

Journal of Affective Disorders

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Section: Introductionmentioning

confidence: 99%

The effects of cognitive reserve and depressive symptoms on cognitive performance in major depression and bipolar disorder

Ponsoni

Branco

Cotrena

et al. 2020

Journal of Affective Disorders

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“…18 A recent study showed that remitted MDD patients had a cognitive performance between healthy controls and non-remitted MDD patients. 19 In the elderly, depressive disorders have also been associated with cognitive deficits after mood symptom remission. 20,21 Interestingly, cognitive impairment seems to be mediated by apathy in elderly subjects with MDD as in neurodegenerative diseases like AD and Parkinson's disease.…”

Section: Depressive Disorders In the Elderly And Cognitive Deficit: Tmentioning

confidence: 99%

Depressive disorders in the elderly and dementia: An update

Dias

Barbosa

Kuang

et al. 2020

Dement. neuropsychol.

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The relationship between depressive disorders in the elderly and dementia, particularly Alzheimer's disease (AD), is highly complex. While the nature of this relationship is still a matter of debate, differential diagnosis and treatment remain a great clinical challenge. We review recent findings on the conundrum of depressive disorders in the elderly and AD. There is a biological continuum between depressive disorders in the elderly -or at least a subgroup of them -and AD. While elderly subjects with depression and patients with AD exhibit higher circulating levels of pro-inflammatory molecules and lower BDNF than matched controls, CSF levels of Aβ42 can discriminate AD from depressive disorders in the elderly. The role of antidepressant treatment as a strategy to minimize the risk of AD remains to be established. A relação entre transtornos depressivos em idosos e demência, particularmente a doença de Alzheimer (DA), é altamente complexa. Embora a natureza desse relacionamento ainda seja motivo de debate, o diagnóstico e o tratamento diferenciais continuam sendo um grande desafio clínico. Revisamos descobertas recentes sobre o dilema de transtornos depressivos em idosos e DA. Existe um contínuo biológico entre os transtornos depressivos em idosos -ou pelo menos um subgrupo deles -e a DA. Enquanto indivíduos idosos com depressão e pacientes com DA exibem níveis circulantes mais altos de moléculas pró-inflamatórias e menor BDNF do que os controles correspondentes, os níveis de Aβ42 no LCR podem discriminar a DA de distúrbios depressivos em idosos. O papel do tratamento antidepressivo como estratégia para minimizar o risco de DA ainda precisa ser estabelecido. Palavras-chave: depressão, demência, Alzheimer, diagnóstico diferencial, terapêutica.

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“…However, these studies do not determine the specific cognitive alterations involved in a recent suicide attempt, that is, the current altered processes that surround and may contribute to suicidal behavior. Besides, these cognitive alterations are not unique to suicide and have also been described in depressive patients (19)(20)(21)(22)(23)(24); therefore, it remains unclear which specific cognitive domains are altered in recent suicidal behavior. Considering data scarcity, the aim of this study was to explore cognitive alterations in recent suicide attempts.…”

Section: Introductionmentioning

confidence: 99%

Cognition in Recent Suicide Attempts: Altered Executive Function

et al. 2021

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Background: Neuropsychological alterations can lead to inaccurate perception, interpretation, and response to environmental information, which could be a risk factor for suicide.Methods: Ninety-six subjects were recruited from the Psychiatry Department of the Araba University Hospital—Santiago, including 20 patients with a recent attempt and diagnosis of major depressive disorder (MDD) according to DSM-V, 33 MDD patients with history of attempted suicide, 23 non-attempter MDD patients, and 20 healthy controls. All participants underwent a clinical interview and neuropsychological assessment on the following cognitive domains: working memory, processing speed, decision-making, executive function, and attention. Backward multiple regressions were performed adjusting for significant confounding variables. For group comparisons, ANOVA and Bonferroni post-hoc tests were performed with a p < 0.05 significance level.Results: The patient groups did not differ regarding severity of depression and stressful events in the last 6 months. In comparison to healthy controls, depressed patients with lifetime suicide attempts had more general trauma (p = 0.003), emotional abuse (p = 0.003), emotional negligence (p = 0.006), and physical negligence (p = 0.009), and depressed patients with recent suicide attempts had experienced more child sexual abuse (p = 0.038). Regarding neuropsychological assessment, all patient groups performed significantly worse than did healthy controls in processing speed, decision-making, and attention. Comparisons between patient groups indicated that recent suicide attempters had poorer performance on executive function in comparison to both depressed lifetime attempters and depressed non-attempters (B = 0.296, p = 0.019, and B = 0.301, p = 0.028, respectively). Besides, women with recent attempts had slightly better scores on executive function than males. Regarding the rest of the cognitive domains, there were no significant differences between groups.Conclusion: Executive function performance is altered in recent suicide attempts. As impaired executive function can be risk factor for suicide, preventive interventions on suicide should focus on its assessment and rehabilitation.

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Neurocognitive performance in patients with depression compared to healthy controls: Association of clinical variables and remission state

Cited by 7 publications

References 56 publications

The effects of cognitive reserve and depressive symptoms on cognitive performance in major depression and bipolar disorder

The effects of cognitive reserve and depressive symptoms on cognitive performance in major depression and bipolar disorder

Depressive disorders in the elderly and dementia: An update

Cognition in Recent Suicide Attempts: Altered Executive Function

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