Neurocognitive improvements following endovascular repair of vein of Galen malformation in a child

Howarth, Robyn; Reisner, Andrew; Chern, Joshua J.; Hayes, Laura L.; Burns, Thomas G.; Berenstein, Alejandro

doi:10.3171/2014.10.peds14244

Cited by 9 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, previous reports may underestimate the rate of overall impairments. Indeed, only two studies have reported on the neuropsychological outcomes of VGAM, one describing outcomes of neonatal VGAM14 and the other a case of a child treated during her preschool years 15. Lecce and colleagues14 document good outcomes in around half of neonatal VGAM survivors, but a closer review of their data shows 74% of their sample had at least one poor outcome.…”

Section: Discussionmentioning

confidence: 99%

Outcome of vein of Galen malformation presenting in the neonatal period

et al. 2019

View full text Add to dashboard Cite

ObjectiveVein of Galenaneurysmal malformation (VGAM) is a rare but important congenital malformation presenting to neonatal intensive care units (NICUs), and with a change from surgical to endovascular management, survival for this condition has improved. However, there is little reported about the medical management decisions of infants with this condition and the associated long-term neurodevelopmental outcomes. We aim to report a single centre experience of both acute treatment and long-term outcomes of VGAM for those infants admitted to our NICU soon after birth.DesignRetrospective cohort study over a 15-year period from 2001 to 2015 inclusive.SettingA quaternary NICU at The Royal Children’s Hospital, Melbourne, Australia.Participants24 newborn infants referred for management of VGAM. There were no eligibility criteria set for this study; all presenting infants were included.InterventionsNone.Main outcomes measuresClinical neuroimaging data were gathered. Surviving children were formally assessed with a battery of tests administered by a neuropsychologist and occupational therapist/physiotherapist at various ages across early to middle childhood.ResultsFifteen neonates with VGAM did not survive beyond their NICU admission. 10 of these were not offered endovascular intervention. Of the nine surviving infants, only one had a normal neurodevelopmental outcome.ConclusionsThe mortality of VGAM presenting in the neonatal period was high, and rates of normal neurodevelopmental outcome for survivors were low. These findings contribute to our understanding of which neonates should be treated and highlights the importance of providing clinical neurodevelopmental follow-up to survivors beyond their infant years.

show abstract

Section: Discussionmentioning

confidence: 99%

Outcome of vein of Galen malformation presenting in the neonatal period

et al. 2019

View full text Add to dashboard Cite

show abstract

“…If VGM is diagnosed in childhood or adolescence and treated appropriately, life expectancy increases significantly [13][14][15]. Emphasis is then placed on treatment of hydrocephalus and recurrent seizures and prophylaxis of intracranial hemorrhage, with the goal of allowing normal or quasi-normal neurological development [16,17]. Persistent venous hypertension with malabsorption of cerebral spinal fluid and initiation of intracranial hemorrhage due to secondary changes in venous outflow (including persistence of fetal falciform sinus, lack of development of the rectus sinus, or dilatation of the internal cerebral veins) are pathophysiological explanations for the exacerbation of symptoms [11,18,19].…”

Section: Clinical Symptoms and Challengesmentioning

confidence: 99%

Neurointerventional Treatment of Vein of Galen Malformation (VGM): A Structured Review with a Proposal for the Comparison of Outcome Quality

Brassel

Schlunz-Hendann

Scholz

et al. 2023

JVD

View full text Add to dashboard Cite

Background: Vein of Galen malformation (VGM) is a congenital intracranial vascular anomaly consisting of arteriovenous fistulas and/or malformations between various arterial feeders and the median prosencephalic vein of Markowski (MPV). Despite its rare occurrence, VGM is of particular clinical relevance, as the excessive intracranial shunt volume leads to high mortality without appropriate treatment. Methods: The objective of this article is to review the published data on neurointerventional treatment and compare outcome quality in the included studies. Eight studies were included and synthesized. One study was multicentric and the rest were retrospective monocentric (level 4 evidence studies according to the Oxford Centre for Evidence-based Medicine). Results: The total number of included patients was 480 and patient age ranged from 1 day to 18 years. Mild or severe heart failure, hydrocephalus, and other reasons led to the indication for neurointerventional treatment, which was performed in all studies in the form of embolization. Under consideration of the introduced semiquantitative multidimensional scoring system, the highest total score, i.e., the best outcome quality, was found for the study “Houston” 2002–2018 (19 points) and the study “Duisburg” 2001–2010 (19 points). Conclusions: Neurointerventional treatment represents the essential pillar in the interdisciplinary management of patients with VGM, although standardization is lacking—based on the results of the structured review. As complementary treatments, pediatric critical care is mandatory and includes medical hemodynamic stabilization.

show abstract

“…If VGM is diagnosed in childhood or adolescence and treated appropriately, life expectancy increases significantly [12]. Emphasis is then placed on treatment of hydrocephalus and recurrent seizures and prophylaxis of intracranial hemorrhage, with the goal of allowing normal or quasi-normal neurological development [13]. Persistent venous hypertension with malabsorption of cerebral spinal fluid and initiation of intracranial hemorrhage due to secondary changes in venous outflow (including persistence of fetal falciform sinus, lack of development of the rectus sinus, or dilatation of the internal cerebral veins) are pathophysiological explanations for the exacerbation of symptoms [14].…”

Section: Introductionmentioning

confidence: 99%

Vein of Galen malformation with Obstructive Hydrocephalus- Endovascular Approach of Management : A Case Report

Md Shafiqul Islam,

Md Motasimul Hasan,

Md Sumon Rana

et al. 2024

Bangla J. Neurosurgery

View full text Add to dashboard Cite

The vein of Galen malformation is a rare arteriovenous shunt that is estimated to represent 30% of all pediatric vascular malformations. Less than 1% of cerebral vascular malformations are aneurysmal abnormalities of the vein of Galen, making it a rare disorder. Despite being uncommon, VGM is of particular clinical importance since the large cerebral shunt volume causes a significant mortality rate when left untreated because to date, the treatment of patients with VGM remains challenging. Here we report a case of an 11-month-old baby who had VGM with obstructive hydrocephalus and was effectively treated by transarterial glue embolization of the fistula and the venous sac. Subsequently, the baby made a complete recovery. Bang. J Neurosurgery 2023; 13(1): 34-40

show abstract

Neurocognitive improvements following endovascular repair of vein of Galen malformation in a child

Cited by 9 publications

References 24 publications

Outcome of vein of Galen malformation presenting in the neonatal period

Outcome of vein of Galen malformation presenting in the neonatal period

Neurointerventional Treatment of Vein of Galen Malformation (VGM): A Structured Review with a Proposal for the Comparison of Outcome Quality

Vein of Galen malformation with Obstructive Hydrocephalus- Endovascular Approach of Management : A Case Report

Contact Info

Product

Resources

About