Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer’s disease and insomnia: A systematic review and meta-analysis of randomized controlled trials

Sumsuzzman, Dewan Md.; Choi, Jeong-Hyun; Jin, Yunho; Hong, Yonggeun

doi:10.1016/j.neubiorev.2021.04.034

Cited by 67 publications

(50 citation statements)

References 86 publications

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“…As one of the most important noxious factors on physical and mental health ( 4 ), sleep disorder (SLD) is reported to be closely associated with development of AD ( 5 – 7 ). Some researchers even believe that SLD has decisive effects on AD ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…The reasons for this significant correlation could be that the SLD can increase stress reactions and impair attention, episodic memory ( 14 ) and cognitive function ( 15 ), increase adrenocorticotropin and cortisol secretion, weaken neuronal structures, increase risk of cell death ( 5 ). Specifically, SLD could increase beta-amyloid production and deposition ( 2 ) and decrease its clearance in the brain ( 7 ), further cause synaptic dysfunction ( 2 ), and exacerbate the deterioration of AD symptoms, especially when both were severe ( 9 ). One review indicates that the treatment of SLD may also alleviate cognitive decline and the risk of AD ( 2 ) and be an effective therapy for AD symptoms ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Brain Functional and Structural Changes in Alzheimer's Disease With Sleep Disorders: A Systematic Review

2021

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Introduction: Sleep disorders (SLD) are supposed to be associated with increased risk and development of Alzheimer's disease (AD), and patients with AD are more likely to show SLD. However, neurobiological performance of patients with both AD and SLD in previous studies is inconsistent, and identifying specific patterns of the brain functional network and structural characteristics in this kind of comorbidity is warranted for understanding how AD and SLD symptoms interact with each other as well as finding effective clinical intervention. Thus, the aims of this systematic review were to summarize the relevant findings and their limitations and provide future research directions.Methods: A systematic search on brain functional and structural changes in patients with both AD and SLD was conducted from PubMed, Web of Science, and EMBASE databases.Results: Nine original articles published between 2009 and 2021 were included with a total of 328 patients with comorbid AD and SLD, 367 patients with only AD, and 294 healthy controls. One single-photon emission computed tomography study and one multislice spiral computed tomography perfusion imaging study investigated changes of cerebral blood flow; four structural magnetic resonance imaging (MRI) studies investigated brain structural changes, two of them used whole brain analysis, and another two used regions of interest; two resting-state functional MRI studies investigated brain functional changes, and one 2-deoxy-2-(18F)fluoro-d-glucose positron emission tomography (18F-FDG-PET) investigated 18F-FDG-PET uptake in patients with comorbid AD and SLD. Findings were inconsistent, ranging from default mode network to sensorimotor cortex, hippocampus, brain stem, and pineal gland, which may be due to different imaging techniques, measurements of sleep disorder and subtypes of AD and SLD.Conclusions: Our review provides a systematic summary and promising implication of specific neuroimaging dysfunction underlying co-occurrence of AD and SLD. However, limited and inconsistent findings still restrict its neurobiological explanation. Further studies should use unified standards and comprehensive brain indices to investigate the pathophysiological basis of interaction between AD and SLD symptoms in the development of the disease spectrums.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Brain Functional and Structural Changes in Alzheimer's Disease With Sleep Disorders: A Systematic Review

2021

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“…Of note, clinical research in humans mainly focuses on potentially beneficial effects of melatonin treatment on cognitive and/or memory function. For instance, a recent systematic review and meta-analysis found that melatonin treatment significantly improved cognitive scores in mild levels of AD ( Sumsuzzman et al, 2021 ). Again, effects on healthy individuals were less clear.…”

Section: Circadian Regulation Of Behaviour and Cognitive Functioningmentioning

confidence: 99%

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health

et al. 2022

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A variety of organisms including mammals have evolved a 24h, self-sustained timekeeping machinery known as the circadian clock (biological clock), which enables to anticipate, respond, and adapt to environmental influences such as the daily light and dark cycles. Proper functioning of the clock plays a pivotal role in the temporal regulation of a wide range of cellular, physiological, and behavioural processes. The disruption of circadian rhythms was found to be associated with the onset and progression of several pathologies including sleep and mental disorders, cancer, and neurodegeneration. Thus, the role of the circadian clock in health and disease, and its clinical applications, have gained increasing attention, but the exact mechanisms underlying temporal regulation require further work and the integration of evidence from different research fields. In this review, we address the current knowledge regarding the functioning of molecular circuits as generators of circadian rhythms and the essential role of circadian synchrony in a healthy organism. In particular, we discuss the role of circadian regulation in the context of behaviour and cognitive functioning, delineating how the loss of this tight interplay is linked to pathological development with a focus on mental disorders and neurodegeneration. We further describe emerging new aspects on the link between the circadian clock and physical exercise-induced cognitive functioning, and its current usage as circadian activator with a positive impact in delaying the progression of certain pathologies including neurodegeneration and brain-related disorders. Finally, we discuss recent epidemiological evidence pointing to an important role of the circadian clock in mental health.

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“…29,30 The mean difference (MD) was used whenever the outcome measures of associated studies utilized the same scale without other significant differences. 31 The detailed data analysis methods used in our study are available in Appendix 1.…”

Section: Analysisofextracteddatamentioning

confidence: 99%

Pre‐ and post‐conditioning with poly I:C exerts neuroprotective effect against cerebral ischemia injury in animal models: A systematic review and meta‐analysis

et al. 2022

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Cerebral ischemia (CI) is a condition where blockage in an artery limits the distribution of oxygen-rich blood to the brain, and this leads to brain tissue damage. Cerebral ischemia may be caused by cardiac arrest, 1 stroke, 2 severe anemia, 3 aging, 4,5 systemic hypotension and hypoxia, 6-8 metabolic derangements, 9,10 or strangulation. 11,12 Severe CI such as stroke has a high death rate with approximately 795,000 people having a stroke each year, 13 and survivors often showing significant neurological disabilities and

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Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer’s disease and insomnia: A systematic review and meta-analysis of randomized controlled trials

Cited by 67 publications

References 86 publications

Brain Functional and Structural Changes in Alzheimer's Disease With Sleep Disorders: A Systematic Review

Brain Functional and Structural Changes in Alzheimer's Disease With Sleep Disorders: A Systematic Review

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health

Pre‐ and post‐conditioning with poly I:C exerts neuroprotective effect against cerebral ischemia injury in animal models: A systematic review and meta‐analysis

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