Neurocognitive Effects in Welders Exposed to Aluminium: An Application of the NPC Test and NPC Ranking Methods

Bonnini, Stefano; Corain, Livio; Munaò, F; Salmaso, Luigi

doi:10.1007/s10260-006-0019-3

Cited by 8 publications

(6 citation statements)

References 17 publications

(19 reference statements)

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“…The negative results may Wt more or less to cross-sectional welder studies showing isolated associations but no systematic patterns (Kiesswetter et al 2007). However, they do not Wt to the systematic associations (Al in serum) indicated in the study of Bonnini et al (2006). The assumption that the unusual high and long exposure in the latter study is the main reason for the underlying structure is not plausible as even the 'young' strata show these associations.…”

Section: Correlation Between Biomarkers Of Exposure and Neurobehaviormentioning

confidence: 60%

“…Two of these studies investigated high Al exposure with up to 270 g Al/l urine (Akila et al 1999;Riihimäki et al 2000) and serum aluminium up to 24 g Al/l (Bonnini et al 2006). Four studies (Hänninen et al 1994;Sjögren et al 1996;Bast-Pettersen et al 2000;Iregren et al 2001) referred to lower internal loads between 20 and 80 g Al/l urine.…”

Section: Introductionmentioning

confidence: 97%

“…Intermediate results, referring to the Wrst two study years, were published by Buchta et al 2003. Neurobehavioral Al-studies With the exception of our recent T-study, all former neurobehavioral Al welder studies are cross-sectional studies (Sjögren et al 1990(Sjögren et al , 1996Hänninen et al 1994;Akila et al 1999;Riihimäki et al 2000;Bast-Pettersen et al 2000;Iregren et al 2001;Giorgianni et al 2003;Bonnini et al 2006).…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Longitudinal study on potential neurotoxic effects of aluminium: II. Assessment of exposure and neurobehavioral performance of Al welders in the automobile industry over 4 years

Kiesswetter

Schäper

Buchta³

et al. 2009

Int Arch Occup Environ Health

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The biomonitoring and neurobehavioral results are in line with the results of the first published study. The repeated measurement models of both studies showed no adverse neurobehavioral effects of Al welding. A modular lifetime-oriented research concept is outlined aiming at the investigation of sequential periods of exposure life with special focus on the biologically most sensitive phases like first exposure and old age.

show abstract

Section: Correlation Between Biomarkers Of Exposure and Neurobehaviormentioning

confidence: 60%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Longitudinal study on potential neurotoxic effects of aluminium: II. Assessment of exposure and neurobehavioral performance of Al welders in the automobile industry over 4 years

Kiesswetter

Schäper

Buchta³

et al. 2009

Int Arch Occup Environ Health

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“…All these properties make NPC test very flexible [ 2 , 24 , 54 ] and widely applied in several fields; in particular we cite recent applications in medical context [ 4 , 7 , 8 , 10 , 16 , 25 , 48 , 53 ] and in genetics [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

Bonferroni-Holm and permutation tests to compare health data: methodological and applicative issues

Giacalone

Zirilli

Cozzucoli

et al. 2018

BMC Med Res Methodol

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BackgroundStatistical methodology is a powerful tool in the health research; however, there is wide accord that statistical methodologies are not usually used properly. In particular when multiple comparisons are needed, it is necessary to check the rate of false positive results and the potential inflation of type I errors. In this case, permutation testing methods are useful to check the simultaneous significance level and identify the most significant factors.MethodsIn this paper an application of permutation tests, in the medical context of Inflammatory Bowel Diseases, is performed. The main goal is to assess the existence of significant differences between Crohn’s Disease (CD) and Ulcerative Colitis (UC). The Sequentially Rejective Multiple Test (Bonferroni-Holm procedure) is used to find which of the partial tests are effectively significant and solve the problem of the multiplicity control.ResultsApplying Non-Parametric Combination (NPC) Test for partial and combined tests we conclude that Crohn’s Disease patients and Ulcerative Colitis patients differ between them for most examined variables. UC patients compared with the CD patients, have a higher diagnosis age, not show smoking status, proportion of patients treated with immunosuppressants or with biological drugs is lower than the CD patients, even if the duration of such therapies is longer. CD patients have a higher rate of re-hospitalization. Diabetes is more present in the sub-population of UC patients. Analyzing the Charlson score we can highlight that UC patients have a more severe clinical situation than CD patients. Finally, CD patients are more frequently subject to surgery compared to UC. Appling of the Bonferroni Holm procedure, which provided adjusted p-values, we note that only nine of the examined variables are statistically significant: Smoking habit, Immunosuppressive therapy, Surgery, Biological Drug, Diabetes, Adverse Events, Re-hospitalization, Gender and Duration of Immunosoppressive Therapy. Therefore, we can conclude that these are the specific variables that can discriminate effectively the Crohn’s Disease and Ulcerative Colitis groups.ConclusionsWe identified significant variables that discriminate the two groups, satisfying the multiplicity problem, in fact we can affirm that Smoking habit, Immunosuppressive therapy, Surgery, Biological Drug, Diabetes, Adverse Events, Hospitalization, Gender and Duration of Immunosoppressive Therapy are the effectively significant variables.

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“…Almost all Al workers studies are cross-sectional studies [7,8]. Most of them are conducted pragmatically aiming at the detection of significant effects and the deduction of threshold limit values [9].…”

Section: Introductionmentioning

confidence: 99%

Exposure Risk Assessment Follow-up in an Aluminium Salvage Plant

Deschamps¹,

Salles²,

Laraqui³

et al. 2018

Adv Tech Biol Med

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Introduction: Workers who work in salvage plant industry are at risk of exposure to aluminum (Al). The objective of this study was to conduct a longitudinal quantitative health risk and bio monitoring assessment for workers exposed to Al.Methods: Al workers were compared to controls. A standardized medical examination and neurobehavioral tests and pulmonary assessment were achieved. The longitudinal study was based on repeated measurements (Airborne and urine Al evaluations). Results:Clinical results showed no evident adverse effects, only mild health impairings. Modification of industrial process to reduce Al exposure leaded paradoxically to increase Al peaks in airborne and urine samples. Conclusion:Hygienic and architectural measures taken to improve exposure and to reduce Al inhalation was a failure. Appropriate preventive measures should be carefully assessed before being applied to protect effectively exposed workers.

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Neurocognitive Effects in Welders Exposed to Aluminium: An Application of the NPC Test and NPC Ranking Methods

Abstract: Aluminium exposure, Dependent rankings, Neurocognitive effects, Nonparametric combination, Permutation tests,

Cited by 8 publications

References 17 publications

Longitudinal study on potential neurotoxic effects of aluminium: II. Assessment of exposure and neurobehavioral performance of Al welders in the automobile industry over 4 years

Longitudinal study on potential neurotoxic effects of aluminium: II. Assessment of exposure and neurobehavioral performance of Al welders in the automobile industry over 4 years

Bonferroni-Holm and permutation tests to compare health data: methodological and applicative issues

Exposure Risk Assessment Follow-up in an Aluminium Salvage Plant

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