Neurocognitive development of children with congenital unilateral brain lesion and epilepsy

Neuropsychological status at seizure onset in children

“…This is consistent with past studies of children diagnosed with epilepsy [6][7][8]10,13 and adds to the conceptualization of deleterious effects of seizures, showing that they are not limited to children with generalized symptomatic epilepsies, frequent sei- Odds ratios are not adjusted for other risk factors. *Percent of children who possessed the risk factor who exhibited a neuropsychological deficit (i.e., scoring Ն1.3 SD below the sibling control group mean) in at least one neuropsychological domain.…”

“…5 Supporting studies have been limited by small sample sizes (n ϭ 12-72 for most), [6][7][8][9][10][11][12][13] exclusion of seizure types/ etiologies, [6][7][8][9][10] long latencies between seizure onset and cognitive assessment, 7,8,12,14 using gross outcome measures 11,12,14 or testing limited functions, 6 no control group, 12,14 using retrospective report, 14 or ignoring prior unrecognized seizures, observed in one third of children. 15,16 Understanding risk factors for early neuropsychological deficiencies is critical for early intervention for common cognitive and academic comorbidities.…”

Life After Perinatal Stroke

“…12 However, studies of congenital hemiplegia (including perinatal stroke) describe increased rates of attention disorders. 11,40 There is also evidence that attention deficit hyperactivity disorder prevalence is increased after childhood stroke and is associated with earlier age at injury. 11,41 Given the potential impact on other elements of development and available treatments, studies of attention disorders after perinatal stroke are urgently needed.…”

Findings of MR Imaging and it's necessity in Children with First Recognized Seizure: A Tertiary Center Based prospective Cohort Study

“…In a very small study of 12 children imaged within two years of diagnosis with partial seizures, Kolk and colleagues [26] observed structural abnormalities in 6 (50%), which is not surprising for partial seizures. Hippocampal lesions accounted for 4 of the 6 abnormalities (67%), andthe other two children had ventricular enlargement or bilateral cortical atrophy.…”