Neurocognitive Deterioration in Elderly Chronic Schizophrenia Patients With and Without PTSD

Goodman, Craig; Finkel, Boris; Naser, Mahmoud; Andreyev, Piter; Segev, Yehoshua; Kurs, Rena; Melamed, Yuval; Bleich, Avi

doi:10.1097/nmd.0b013e31802c1424

Cited by 26 publications

(9 citation statements)

References 31 publications

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“…This result was in line with our main findings where no significant differences in cognitive functioning between SZ patients with trauma, PTSD, or no trauma were seen. However, some studies have found an association of comorbid PTSD with cognitive dysfunction in schizophrenia . Fan and colleagues suggest that patients with comorbid PTSD ( n = 15 ) suffer more cognitive impairments especially in the domains of attention, working memory, and executive functioning, compared with those who have not developed PTSD.…”

Section: Discussionmentioning

confidence: 99%

Schizophrenia patients with and without Post‐traumatic Stress Disorder (PTSD) have different mood symptom levels but same cognitive functioning

Peleikis

Varga

Lorentzen

et al. 2012

Acta Psychiatr Scand

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OA. Schizophrenia patients with and without Post-traumatic Stress Disorder (PTSD) have different mood symptom levels but same cognitive functioning.Objective: To investigate differences in cognitive function and level of psychopathology in patients with schizophrenia (SZ) with or without psychological traumatization/post-traumatic stress disorder (PTSD). We hypothesized that traumatized patients with or without PTSD would have more severe cognitive impairments because of the neuropathological changes associated with PTSD, and more severe psychopathology compared with non-traumatized SZ patients. Method: Seventy-five SZ patients with traumatization and 217 SZ patients without traumatization were evaluated regarding the symptoms and cognitive functioning, using standard symptom scales (PANSS; CDSS) and a neuropsychological test battery (IQ, verbal memory, attention, working memory, psychomotor speed, and executive functioning). Results: No significant differences were observed between the groups in cognitive test performance. The patients in the traumatized group with PTSD showed significantly more current depression than the nontraumatized group (P = 0.012). Conclusion: The findings did not support the hypothesis that the presence of comorbid PTSD/traumatization in SZ is associated with increased cognitive impairment. The increase in current depression in SZ with comorbid traumatization suggests that more severe psychopathology is associated with traumatization. Significant outcomes• No significant differences were observed between the groups in cognitive test performance.• Schizophrenia patients with trauma and post-traumatic stress disorder (PTSD) had significantly more current depression than the non-traumatized group. Limitations• Given the nature of the cross-sectional design, causal relationships between traumatization/PTSD, schizophrenia, and functional measures cannot be drawn.• Some questionnaires have a low response rate Calgary Depression Scale for Schizophrenia (CDSS).• Heterogeneity within the trauma group with regard to the type and age when the traumatic event happened complicates the interpretation of our results. 455

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Section: Discussionmentioning

confidence: 99%

Schizophrenia patients with and without Post‐traumatic Stress Disorder (PTSD) have different mood symptom levels but same cognitive functioning

Peleikis

Varga

Lorentzen

et al. 2012

Acta Psychiatr Scand

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“…Medical and psychological comorbidities can also play an additional role in cognitive deficits, especially in older patients with schizophrenia (Goodman et al . 2007; Dickinson et al . 2008; Manning et al .…”

Section: Evidence For Illness-related Pathological Progression In Schmentioning

confidence: 99%

“…Current evidence suggests that illnessrelated cognitive abnormalities in schizophrenia are mostly neurodevelopmental in origin. Medical and psychological comorbidities can also play an additional role in cognitive deficits, especially in older patients with schizophrenia (Goodman et al 2007;Dickinson et al 2008;Manning et al 2009;Friedman et al 2010;Bora, 2015;Bora et al 2017b).…”

Section: Illusion Of Progression In Schizophreniamentioning

confidence: 99%

A neurodevelopment and neuroplasticity-based framework for early intervention in psychotic disorders

Bora

2017

Psychol. Med.

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In recent years there has been growing interest in early intervention in psychotic disorders and a number of clinical and research programmes have been developed. The clinical staging model has been an essential part of early intervention as it provides the rationale of existing programmes. In medicine, clinical staging is a valuable approach in disorders where primary pathology is progressive in nature. However, the clinical staging model of psychosis has been proposed without establishing first that schizophrenia is a primarily progressive disorder. In reviewing existing evidence, this current paper argues that cross-sectional data interpreted as supportive of clinical staging data does not consider the effects of sampling bias, problems in reliability in assessing 'soft symptoms', or false positives. Longitudinal neurobiological studies do not provide a convincing case for primarily progressive pathology in schizophrenia. Clinical progression in schizophrenia can be better conceptualised as neuroplastic changes in response to interaction between core developmental pathology and environmental stimuli. An alternative rationale for early and continuous intervention targeting neurodevelopmental abnormality and neuroplastic changes, as well as medical and psychological comorbidities, is proposed in this paper.

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“…While PTSD re-experiencing symptoms were strongly associated with a predisposition to hallucinations, negative beliefs about self and others were most associated with a predisposition to paranoia (2). Studies assessing cognition in elderly people with schizophrenia have described greater compromise in subjects exposed to more stressful events (3). Suicidality in schizophrenia has been also associated with traumatic experiences (4).…”

mentioning

confidence: 99%

Diagnostic and therapeutic challenges involving patients with post-traumatic stress disorder and schizoaffective disorder depressive type

Nicolato¹,

Dias²,

Salgado³

et al. 2009

Acta Neuropsychiatr.

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Neurocognitive Deterioration in Elderly Chronic Schizophrenia Patients With and Without PTSD

Cited by 26 publications

References 31 publications

Schizophrenia patients with and without Post‐traumatic Stress Disorder (PTSD) have different mood symptom levels but same cognitive functioning

Schizophrenia patients with and without Post‐traumatic Stress Disorder (PTSD) have different mood symptom levels but same cognitive functioning

A neurodevelopment and neuroplasticity-based framework for early intervention in psychotic disorders

Diagnostic and therapeutic challenges involving patients with post-traumatic stress disorder and schizoaffective disorder depressive type

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