Neurocognitive Aspects of Hypothyroidism

Dugbartey, Anthony T.

doi:10.1001/archinte.158.13.1413

Cited by 217 publications

(165 citation statements)

References 72 publications

(71 reference statements)

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“…40% of chronically hypothyroid patients. Hypothyroidism, even in a mild form, is clearly associated with neurocognitive dysfunction including memory loss and depression (24). Taken together with the results of earlier DTC studies (4,20), our observations suggest that the association between short-term hypothyroidism and depression is less clear.…”

Section: Dtc-h (%)supporting

confidence: 57%

Health-related quality of life, anxiety and depression in thyroid cancer patients under short-term hypothyroidism and TSH-suppressive levothyroxine treatment

Tagay¹,

Herpertz

Langkafel³

et al. 2005

eur j endocrinol

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Objective: Very few previous studies have compared the degree of health-related quality of life (HRQL), depression and anxiety of differentiated thyroid cancer patients (DTC) under short-term hypothyroidism and levothyroxine treatment. Methods: Using patient-completed instruments, we examined the frequency of physical complaints, HRQL, anxiety and depression in 130 DTC patients hospitalized for radioiodine therapy or wholebody diagnostics (age 52 years, female 71%) under short-term hypothyroidism (4 weeks of levothyroxine withdrawal; DTC-H) and in 100 DTC out-patients under TSH-suppressive doses of levothyroxine subsequent to radioiodine therapy (DTC-L; age 49 years, female 81%). Results: Compared with the German general population, DTC-H as well as DTC-L patients had significantly impaired HRQL. Notably, the decrease in HRQL was significantly higher in DTC-H than in DTC-L patients. Surprisingly, the prevalence of anxiety (44.6%) but not depression (17.7%) was much higher in the DTC-H patients than in the general population. In contrast to expectations, similar results for anxiety (44.0%) and depression (17.6%) were observed in the DTC-L patients. Conclusions: This mounting evidence suggests that a consistent pattern of HRQL impairment is experienced by patients with DTC. The high frequency of anxiety and the significantly reduced HRQL should be considered in the aftercare of DTC patients.

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Section: Dtc-h (%)supporting

confidence: 57%

Health-related quality of life, anxiety and depression in thyroid cancer patients under short-term hypothyroidism and TSH-suppressive levothyroxine treatment

Tagay¹,

Herpertz

Langkafel³

et al. 2005

eur j endocrinol

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“…Inadequate hormone replacement may lead to cardiovascular disease [17], arrhythmias [18], neurocognitive alterations [19], and osteoporosis and fractures [20,21]. In this context, the aims of the study were to establish the percentage of patients in whom TSH levels remained within the normal range during a 4 year follow-up and to describe the factors associated with good TSH control in this population.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with the Stability of Thyroid-stimulating Hormone Values in Hypothyroidism

Marta¹

2017

Arch Med

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In the treatment of hypothyroidism, thyroid-stimulating hormone (TSH) and thyroid hormones are measured and the levothyroxine dose is adjusted in order to achieve a euthyroid state. The initial dose is calculated according to weight, but other factors can influence the dose required to stabilize TSH.Objective: To estimate the percentage of patients who achieve good control of TSH over a 4-year follow-up period; to assess the factors associated with TSH instability.Design: Retrospective population-based cohort study of patients treated for hypothyroidism in a health region in Catalonia, Spain (2010Spain ( -2014. The data were obtained from the pharmacy drug dispensation register included in the computerized medical records of the regional health system. Setting: Lleida health region (Catalonia, Spain).Participants: All patients who had an initial normal TSH value (0.27-5.0 mU/L) or had received levothyroxine were selected. Main measurements:The variables analyzed were: TSH values during follow-up, estimated time with normal TSH, age, sex, body mass index, and compliance with treatment.Results: Of the 2,630 patients with hypothyroidism, 90.3% were women. Mean age was 59.6 years and the treatment compliance rate 84.9%. Patients taking a medium dose of levothyroxine (75-125 mcg) and older patients had higher TSH stability and maintained normal TSH levels for longer (p<0.05). Conclusions:A fifth of patients with hypothyroidism had inadequate thyroid hormone replacement in the first year. Factors associated with TSH stability were levothyroxine dose in the medium range and older age.

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“…12, 13 Therefore, this emphasises the importance of assessment of cognitive functions in follow-ups.…”

mentioning

confidence: 99%

Hypothyroidism in the elderly: heralding myxoedema coma

Renjhen¹,

Sundar²

2016

Prog. Neurol. Psychiatry

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Certain physical health problems in the elderly population often result in impairment of cognitive abilities and acute behavioural issues, so pose a challenge to the treating team. The authors describe a case of hypothyroidism with psychological symptoms of general blunting of personality, mental lethargy and memory impairment from the early stages of the disease, with difficulty in recording events and happenings of day‐to‐day activities. They further describe how these resolve upon correction of the underlying physical health issues.

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Neurocognitive Aspects of Hypothyroidism

Cited by 217 publications

References 72 publications

Health-related quality of life, anxiety and depression in thyroid cancer patients under short-term hypothyroidism and TSH-suppressive levothyroxine treatment

Health-related quality of life, anxiety and depression in thyroid cancer patients under short-term hypothyroidism and TSH-suppressive levothyroxine treatment

Factors Associated with the Stability of Thyroid-stimulating Hormone Values in Hypothyroidism

Hypothyroidism in the elderly: heralding myxoedema coma

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