Neurocognitive and symptomatic predictors of functional outcome in bipolar disorders: A prospective 1 year follow-up study

Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study

“…In this regard, previous studies have reported that unemployment would be particularly impaired in those with processing speed deficits (Mur et al 2008) or with attention deficits (O'Shea et al 2010). Previous longitudinal studies evaluating clinical and neurocognitive predictors of functional outcome by means of the FAST (Martino et al 2009 ;Bonnín et al 2010) or other scales (Burdick et al 2010) have demonstrated the strong relationship of neuropsychological performance and the daily functioning of patients. The cognitive variables that appeared to be related with poor functional outcome were processing speed (Burdick et al 2010), verbal memory and executive functions , and verbal memory and attention (Martino et al 2009).…”

Bipolar bozuklukta işleyiş ve yaşam kalitesi

“…Depressive symptoms are found to be the main predictor of functioning in bipolar patients. In an Argentinian study, the time spent with subsyndromal depressive symptomatology was an independent predictor of long-term psychosocial functioning assessed with the GAF (19). Subsyndromal depressive symptomatology was related with functional role impairments in multiple domains (20).…”

“…Martino et al (19) found that impairments in attention and executive functioning were independent predictors of FAST score explaining 28% of variance. In the analysis, they found that impairments in measures of attention, executive function, and verbal memory were independent predictors of functional outcome level one year later.…”

Psychosocial Functioning in Bipolar Disorder from a Social Justice Perspective

“…A more severe illness history -including a younger age at onset (Hays, Krishnan, George, & Blazer, 1998) and a greater number of mood episodes (MacQueen et al, 2000) and psychiatric hospitalizations (Altshuler et al, 2007) -yields reduced functioning even during euthymia (Martinez-Aran et al, 2004;Zubieta, Huguelet, O'Neil, & Giordani, 2001). In addition, common comorbidities of BD, such as anxiety (Boylan et al, 2004;Kauer-Sant Anna et al, 2007) and substance use disorders (SUD; Jaworski et al, 2011;Lagerberg et al, 2010), disrupt identity development (Michalak et al, 2011), increase symptoms and social avoidance (Jaworski et al, 2011;Otto et al, 2006), interfere with interpersonal engagement (Elgie & Morselli, 2007), exacerbate cognitive impairment (Latvala et al, 2009;Levy & Weiss, 2009;Silva & Leite, 2000), and generally reduce functioning (Goldstein & Levitt, 2008;Sanchez-Moreno et al, 2009 In euthymic BD, two of the strongest predictors of social and occupational functioning are subsyndromal depressive symptoms and cognitive impairment (Bearden et al, 2011;Bonnin et al, 2010;Dickerson et al, 2010;Martínez-Arán et al, 2011;Martino et al, 2009;Tabares-Seisdedos et al, 2008). Even very mild subsyndromal depression leads to reduced functioning including poorer vocational performance (Bearden et al, 2011;Gitlin, Mintz, Sokolski, Hammen, & Altshuler, 2010).…”