Neurocognitive and quality of life study in perinatally HIV-infected young people and their peers. NeuroCoRISpeS study

García-Navarro, Cristina; Martín-Bejarano, Manuela; Ory, Santiago Jiménez de; Zamora, Berta; Ruiz-Saez, Beatriz; Velo, Carlos; Cuéllar-Flores, Isabel; López‐Hortelano, Milagros García; Guillén-Martín, Sara; Navarro-Gómez, María Luisa; Ramos, José Tomás; González-Tomé, María Isabel

doi:10.1016/j.eimc.2020.01.004

Cited by 1 publication

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“…This work is included in a prospective and ongoing cohort study (NeuroCoRISpe) to analyze the psychosocial, neurocognitive, and neuroimaging profile of vertically HIV-infected children. [26][27][28] This manuscript focuses on the cross-sectional assessment of their SQ.…”

Section: Participants and Proceduresmentioning

confidence: 99%

Sleep Profile and Self-Reported Neuropsychiatric Symptoms in Vertically HIV-Infected Adolescents on cART

González-Tomé

García-Navarro

Ruiz-Saez

et al. 2018

J Pediatr Infect Dis

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Background Sleep quality (SQ) data in human immunodeficiency virus (HIV) pediatric population are scarce. Our main objective was to assess SQ in our cohort and to determine the impact of antiretroviral therapy (ART) on sleep in a cohort of HIV-infected adolescents on cART. Materials and Methods The SQ was assessed through the Pittsburgh Sleep Quality Index (PSQI). Neuropsychiatric symptoms (NS) were recorded using an auto-administered questionnaire. To determine the antiretroviral (ARV) impact of efavirenz (EFV) on SQ, patients on EFV versus protease inhibitors-based regimens were compared. Results Forty-six patients were evaluated (median age: 16 years, interquartile range [IQR]: 10.8, 17)). Age at the start of ART: 1.3 years (0.4, 5.2); 23.9% showed acquired immunodeficiency syndrome (AIDS) category. Median CD4 at baseline was 656 (550, 808) cells/mm3; 91.3% had viral load <50 copies/mL. Median time on cART was 11.3 years (7.5, 15.2). Fifty-two percent of the patients were on EFV-based regimen. No differences were found in clinical and immunovirological variables although patients on EFV were older and were exposed for a longer time to ARV. Poor SQ was found in 26.1% of patients. Most frequent complaints were: sleep disturbances (76.1%), sleep latency (63%), and daytime dysfunction (54.3%). Similarly, there were no significant differences in NS between both treatment groups according to patients' reports but were significantly more common in bad sleepers. Patients on EFV-based regimen were more likely to repeat one or more school grades after the adjustment for age at evaluation and nadir CD4 percentage (odds ratio [OR]: 14.421, confidence interval [CI] 95%: 1.207–172.249, p = 0.035). Conclusions Sleep complaints and NS are common among our cohort of HIV adolescents on long-term cART and interestingly, not only in those who were receiving EFV.

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Section: Participants and Proceduresmentioning

confidence: 99%