Neurocognitive and Neuropsychological Effects of OSA

Spector, Andrew R.; Farrer, Thomas J.

doi:10.1007/978-3-030-54146-0_4

Cited by 1 publication

(2 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… * Mean Scores for Insomnia/OSA Separately and No Sleep Issues approximated from the literature [ 47 ] COMISA, comorbid insomnia and sleep apnea † Higher Score indicates poorer performance. …”

Section: Resultsmentioning

confidence: 99%

“…These neurocognitive impairments may be a result of the combined effects of hypoxia (OSA [ 47 ],) and sleep fragmentation/deprivation (OSA and insomnia [ 47 , 48 ],). Impairments in these areas are significant, as this may lead to an increased risk of motor vehicle accidents [ 26 , 49 , 50 ], poor decision-making [ 50–52 ], increases symptoms of psychiatric disorders like depression and anxiety [ 53 , 54 ], and decreased quality of life [ 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neurocognitive functioning in comorbid insomnia and sleep apnea patients is better after positive airway pressure therapy, but worse after cognitive behavioral therapy for insomnia: exploratory analysis of cognitive outcomes from the Multidisciplinary Approach to the Treatment of Insomnia and Comorbid Sleep Apnea study

Turner

Ong

Jones

et al. 2023

Sleep

View full text Add to dashboard Cite

Study Objectives Neurocognitive impairments in comorbid insomnia and sleep apnea (COMISA) are not well documented. We explored neurocognitive functioning and treatment effects in individuals with COMISA as an ancillary study to a randomized clinical trial (RCT). Methods Participants with COMISA (n=45; 51.1% female; mean age=52.07±13.29 years), from a 3-arm RCT combining Cognitive Behavioral Therapy for insomnia (CBT-I) and Positive Airway Pressure (PAP) concurrently (CBT-I+PAP) or sequentially, completed neurocognitive testing at baseline, and post-treatment. Using Bayesian linear mixed models, we estimated effects of CBT-I, PAP, or CBT-I+PAP, compared to baseline, and CBT-I+PAP compared to PAP on 12 metrics across 5 cognitive domains. Results This COMISA sample had worse neurocognitive performance at baseline than reported for insomnia, sleep apnea, and controls in the literature, though short-term memory and psychomotor speed performance appears intact. When comparing PAP to baseline, performance on all measures was better after treatment. Performance after CBT-I was worse compared to baseline, and only performance in attention/vigilance, executive functioning via Stroop interference and verbal memory was better with moderate-high effect sizes and moderate probability of superiority (61-83). Comparisons of CBT-I+PAP to baseline generated results similar to PAP and comparing CBT-I+PAP to PAP revealed superior performance in only attention/vigilance via PVT lapses and verbal memory for PAP. Conclusions Treatment combinations involving CBT-I were associated with poorer neurocognitive performance. These potentially temporary effects may stem from sleep restriction, a component of CBT-I often accompanied by initially reduced total sleep time. Future studies should examine long-term effects of individual and combined COMISA treatment pathways to inform treatment recommendations.

show abstract