Neurocognition in First-Episode Schizophrenia: A Meta-Analytic Review

Mesholam-Gately, Raquelle I.; Giuliano, Anthony J.; Goff, Kirsten P.; Faraone, Stephen V.; Seidman, Larry J.

doi:10.1016/j.schres.2010.02.558

Cited by 227 publications

(341 citation statements)

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“…WTAR has been shown to be stable in patients with traumatic brain injury (Green et al, 2008;Hanks et al, 2008) or exerting suboptimal effort (Whitney et al, 2010). Reading abilities are also widely used in order to infer premorbid IQ in psychosis, as related to measures of full scale IQ, verbal IQ, verbal comprehension (Hanks et al, 2008) and verbal memory (Whitney et al, 2010), the latter being more impaired than general IQ at first episode of psychosis (Mesholam-Gately et al, 2009). This discrepancy between verbal and non-verbal scores in psychotic patients (Wilk et al, 2005) has been shown in people with a genetic liability to develop schizophrenia (Kravariti et al, 2006).…”

Section: Iq Assessmentmentioning

confidence: 99%

Cannabis users have higher premorbid IQ than other patients with first onset psychosis

Ferraro

Russo

O’Connor

et al. 2013

Schizophrenia Research

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a b s t r a c t a r t i c l e i n f oBackground: A number of studies have reported that patients with psychosis who use cannabis have better cognitive performance than those who do not. This is surprising as cannabis can impair cognition in healthy subjects. An obvious question is whether the better current performance of psychotic patients who have used cannabis is a reflection of their having a higher premorbid IQ than those psychotic patients who haven't used cannabis. Aim: In a sample of patients at their first episode of psychosis, we tested the hypothesis that patients who smoked cannabis would have a higher premorbid IQ than patients who did not. Methodology: 279 participants (119 patients and 160 healthy controls) were assessed in order to obtain current and premorbid IQ measures and detailed information on cannabis use. We examined the association between cannabis use and both premorbid and current IQ in patients and controls. Results: Patients who had ever smoked cannabis had significantly higher current (p b .001) and premorbid IQ (p = .004) compared to patients who had never used cannabis. This difference was not found among controls. Conclusions: These findings suggest that the better cognitive performance of patients with their first episode of psychosis who have used cannabis compared with those who haven't is due to the better premorbid IQ of the former.

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Section: Iq Assessmentmentioning

confidence: 99%

Cannabis users have higher premorbid IQ than other patients with first onset psychosis

Ferraro

Russo

O’Connor

et al. 2013

Schizophrenia Research

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“…Cognition tends to remain relatively stable over the course of the illness, at most improving modestly, with those at the first episode exhibiting impairment of a similar severity to those with a more chronic course of illness (Mesholam-Gately et al 2009).…”

Section: Introductionmentioning

confidence: 99%

The role of cognitive functioning in the outcome of those at clinical high risk for developing psychosis

Addington

Barbato

2012

Epidemiol Psychiatr Sci

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Although it is well established that cognitive impairment is a common feature of schizophrenia, only recently has cognitive functioning been prospectively studied in individuals at clinical high risk (CHR) for developing psychosis. To date, both cross-sectional and longitudinal studies have been conducted in the CHR population and in the context of later conversion to psychosis. A comprehensive review of the literature suggests that CHR individuals have general and specific baseline cognitive deficits compared to healthy controls. As a group, their cognitive course, tends to remain stable over time and in this way does not differ from healthy controls. For those who go on to develop a full-blown psychotic illness compared to those who do not convert, there appeared to be minimal differences at baseline with respect to cognition, although over time the converters may show deterioration in certain cognitive abilities compared to the non-converters. However, for many cognitive domains results are mixed, and may result from methodological limitations.

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“…Furthermore, there is a strong body of evidence for cognitive deficits in schizophrenia and even before the onset of psychosis (see e.g. Riecher-Rossler et al, 2009;Mesholam-Gately et al, 2009;Yung and McGorry, 1996b).…”

Section: Introductionmentioning

confidence: 99%

The Self-screen-Prodrome as a short screening tool for pre-psychotic states

Müller

Vetter

Buchli-Kammermann

et al. 2010

Schizophrenia Research

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Background: Early detection of psychosis is an important issue in current research. Early intervention helps to improve the outcome of the disorder. Therefore, a comprehensive examination in large populations, necessary as it might be, is economically almost not feasible. A screening via self-report is more practicable as it helps focus on individuals with high symptom loads. Results: Both groups (cases and non-cases) showed significant differences in their mean scores on SPro and ESI, although only the SPro had satisfactory effect sizes. In hierarchic logistic regression models the SPro turned out to be highly predictive for caseness while ESI scales were not significant. A cut-off score of ≥2 on the Spro subscale for psychotic risk (SPro-Psy-Risk) was found to identify caseness best with a sensitivity of 74% and a specificity of 61%. Conclusion:The SPro has proven to be a valid and very economic screening tool for general and prodromal pathology in large populations.

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Neurocognition in First-Episode Schizophrenia: A Meta-Analytic Review

Cited by 227 publications

References 0 publications

Cannabis users have higher premorbid IQ than other patients with first onset psychosis

Cannabis users have higher premorbid IQ than other patients with first onset psychosis

The role of cognitive functioning in the outcome of those at clinical high risk for developing psychosis

The Self-screen-Prodrome as a short screening tool for pre-psychotic states

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