Neurochemistry of the Sympathetic Innervation to the Uterus

Bell, Christopher; Malcolm, S. J.

doi:10.1111/j.1440-1681.1988.tb01126.x

Cited by 19 publications

(5 citation statements)

References 8 publications

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“…1973, Zoubina & Smith 2001), whereas progesterone plays a key role in degeneration of uterine sympathetic nerves during pregnancy (Thorbert et al. 1976, Bell & Malcolm 1978, 1988).…”

Section: Adult Plasticity Of Uterine Sympathetic Nervesmentioning

confidence: 99%

Paracrine control of vascular innervation in health and disease

Storkebaum

Carmeliet

2011

Acta Physiologica

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Proper vascular regulation is of paramount importance for the control of blood flow to tissues. In particular, the regulation of peripheral resistance arteries is essential for several physiological processes, including control of blood pressure, thermoregulation and increase of blood flow to central nervous system and heart under stress conditions such as hypoxia. Arterial tone is regulated by the periarterial autonomic nervous plexus, as well as by endothelium-dependent, myogenic and humoral mechanisms. Underscoring the importance of proper vascular regulation, defects in these processes can lead to diseases such as hypertension, orthostatic hypotension, Raynaud's phenomenon, defective thermoregulation, hand-foot syndrome, migraine and congestive heart failure. Here, we review the molecular mechanisms controlling the development of the periarterial nerve plexus, retrograde and localized signalling at neuro-effector junctions, the molecular and cellular mechanisms of vascular regulation and adult plasticity and maintenance of periarterial innervation. We particularly highlight a newly discovered role for vascular endothelial growth factor in the structural and functional maintenance of arterial neuro-effector junctions. Finally, we discuss how defects in neuronal vascular regulation can lead to disease.

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“…1973, Zoubina & Smith 2001), whereas progesterone plays a key role in degeneration of uterine sympathetic nerves during pregnancy (Thorbert et al. 1976, Bell & Malcolm 1978, 1988).…”

Section: Adult Plasticity Of Uterine Sympathetic Nervesmentioning

confidence: 99%

Paracrine control of vascular innervation in health and disease

Storkebaum

Carmeliet

2011

Acta Physiologica

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“…1987). Although the former effect may be due to progesterone (Bell & Malcolm 1988), the latter change is only partially mimicked by treatment of oestrogen-primed virgin guinea-pigs with progesterone (Hartley et a/. 1983b-d;Story el al.…”

Section: Discussionmentioning

confidence: 94%

Β‐adrenoceptors in Circular and Longitudinal Myometrial Membranes and in Lung Membranes From Dioestrous and Post‐partum Guinea‐pigs

Handberg

Davis

Hall

et al. 1988

Clin Exp Pharma Physio

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1. We have examined the binding of (-)[125]-cyanopindolol ((-)[125I]-CYP) to membranes prepared from uterus and lung of dioestrous and post-partum (1-6 days) guinea-pigs. 2. The densities of beta-adrenoceptor binding sites in circular and longitudinal myometrium from dioestrous animals were similar, and approximately one-eight of those in the lung. Ascorbate and ethylenediaminetetraacetic acid in the incubation medium did not affect binding. 3. The numbers and affinities of beta-adrenoceptor binding sites in both myometrial layers and in lung parenchyma from post-partum animals were similar to those in corresponding tissues from dioestrous animals. 4. The distribution of beta-adrenoceptor binding sites in the post-partum uterus was examined using receptor autoradiography. Binding to circular and longitudinal muscle layers and to the endometrium was inhibited by (-)-propranolol (1 mumol/l), by the beta 2-adrenoceptor selective antagonist ICI 118,551 (70 nmol/l), but not by the beta 1-adrenoceptor selective antagonist CGP 20712A (100 nmol/l), indicating that the beta-adrenoceptor present was of the beta 2-subtype. 5. The ability of isoprenaline to compete for (--)[125]-CYP binding sites in uterine membranes from post-partum animals was approximately twice that in corresponding preparations from dioestrous animals. 6. Changes in the numbers or affinity of beta 2-adrenoceptors cannot account for the marked and selective enhancement of the actions of sympathomimetic amines at beta-adrenoceptors previously observed in longitudinal myometrium taken from post-partum guinea-pigs. It is suggested that enhancement of later steps in the chain of events between beta-adrenoceptor occupancy and uterine relaxation, and/or a decrease in the contribution of alpha-adrenoceptors to the net effect of the amine might provide alternative explanations.

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“…45 As this hormone is especially linked to pregnancy, several authors that have used experimental models in induced pregnancy states have described modifications of NA levels 46 accompanied by a degeneration of uterine nerves. 47,48 These findings shine a light on the complexity of the neuroplasticity phenomenon. It involves multiple factors orchestrated by the estrogen and progesterone hormones in the reproductive organ.…”

Section: Estrogen Progesterone and Uterine Nerve Plasticitymentioning

confidence: 90%

Neural plasticity of the uterus: New targets for endometrial cancer?

Luna

Soler

Caruana

et al. 2022

Womens Health (Lond Engl)

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Endometrial carcinoma is the most common gynecological malignancy in Western countries and is expected to increase in the following years because of the high index of obesity in the population. Recently, neural signaling has been recognized as part of the tumor microenvironment, playing an active role in tumor progression and invasion of different solid tumor types. The uterus stands out for the physiological plasticity of its peripheral nerves due to cyclic remodeling brought on by estrogen and progesterone hormones throughout the reproductive cycle. Therefore, a precise understanding of nerve-cancer crosstalk and the contribution of the organ-intrinsic neuroplasticity, mediated by estrogen and progesterone, of the uterine is urgently needed. The development of new and innovative medicines for patients with endometrial cancer would increase their quality of life and health. This review compiles information on the architecture and function of autonomous uterine neural innervations and the influence of hormone-dependent nerves in normal uterus and tumor progression. It also explores new therapeutic possibilities for endometrial cancer using these endocrine and neural advantages.

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Neurochemistry of the Sympathetic Innervation to the Uterus

Cited by 19 publications

References 8 publications

Paracrine control of vascular innervation in health and disease

Paracrine control of vascular innervation in health and disease

Β‐adrenoceptors in Circular and Longitudinal Myometrial Membranes and in Lung Membranes From Dioestrous and Post‐partum Guinea‐pigs

Neural plasticity of the uterus: New targets for endometrial cancer?

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