Neurochemistry and epileptology

Rijn, Clementina M. van; Meinardi, H.

doi:10.1111/j.1528-1167.2009.02036.x

Cited by 3 publications

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Relationship between thresholds to convulsions induced by a benzodiazepine inverse agonist and [3H]-l-glutamate binding in the membranes of brain regions

2012

View full text Add to dashboard Cite

Although some studies have investigated the influence of kindling model of epilepsy on the glutamatergic neurotransmission, the relation between glutamatergic receptors and seizure susceptibility remains unclear. The present study sought to determine if rats with high (HTR) and low (LTR) thresholds to clonic convulsions induced by the benzodiazepine inverse agonist DMCM differed in the [(3)H]-L-glutamate binding to membranes from discrete brain regions. Compared to the HTR subgroup, the LTR subgroup presented a lower binding of [(3)H]-L-glutamate in the hippocampus, frontal cortex and amygdala plus limbic cortex, suggesting that glutamatergic receptors in these brain regions may underlie the susceptibility to DMCM-induced convulsions.

show abstract

Relationship between thresholds to convulsions induced by a benzodiazepine inverse agonist and [3H]-l-glutamate binding in the membranes of brain regions

2012

View full text Add to dashboard Cite

show abstract

Rats With Different Thresholds to Clonic Convulsions Induced by DMCM Differ in the Binding of [3H]-MK-801 and [3H]-Ouabain in the Membranes of Brain Regions

2012

View full text Add to dashboard Cite

Considering the putative participation of N-methyl-D-aspartate (NMDA) receptors and the Na(+), K(+)-ATPase enzymes in the susceptibility to convulsions induced by the benzodiazepine inverse agonist methyl 6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate (DMCM), the present study sought to determine if rats with high (HTR) and low (LTR) thresholds to clonic convulsions induced by DMCM differed in the following aspects: the binding of NMDA receptors by [(3)H]-MK-801, Na(+), K(+)-ATPase activity (K(+)-stimulated p-nitrophenylphosphatase) and high-affinity [(3)H]-ouabain binding to membranes from discrete brain regions. Compared to the HTR subgroup, the LTR subgroup presented a lower binding of [(3)H]-MK-801 in the hippocampus, frontal cortex and striatum. The subgroups did not differ in K(+)-p-nitrophenylphosphatase activity, but the LTR subgroup had a lower density of isozymes with a high-affinity to ouabain in the brainstem and in the frontal cortex and a lower affinity to ouabain in the hippocampus than the HTR subgroup. These results suggest that NMDA receptors and ouabain-sensitive Na(+), K(+)-ATPase isozymes may underlie the susceptibility to DMCM-induced convulsions.

show abstract

Pathophysiology of Epilepsy

Jenrow¹,

Elisevich²

2019

Understanding Epilepsy

View full text Add to dashboard Cite

Neurochemistry and epileptology

Cited by 3 publications

References 106 publications

Relationship between thresholds to convulsions induced by a benzodiazepine inverse agonist and [3H]-l-glutamate binding in the membranes of brain regions

Relationship between thresholds to convulsions induced by a benzodiazepine inverse agonist and [3H]-l-glutamate binding in the membranes of brain regions

Rats With Different Thresholds to Clonic Convulsions Induced by DMCM Differ in the Binding of [3H]-MK-801 and [3H]-Ouabain in the Membranes of Brain Regions

Pathophysiology of Epilepsy

Contact Info

Product

Resources

About