Neurochemical Roles of Copper as Antioxidant or Prooxidant

Prohaska, Joseph R.

doi:10.1007/978-1-4899-0197-2_4

Cited by 6 publications

(3 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is associated with the generation of reactive oxygen radicals, leading to peroxidation and damage of membrane lipids and proteins [45][46][47][48] including the Na + /K + -ATP-ase α-subunit. The previous studies on the rat kidneys showed that heavy metals (e.g., Cd) impaired the activity of Na + /K + -ATP-ase [38,43].…”

Section: Discussionmentioning

confidence: 99%

Effects of Copper Supplementation on the Structure and Content of Elements in Kidneys of Mosaic Mutant Mice

Lenartowicz

Windak

Tylko

et al. 2009

Biol Trace Elem Res

View full text Add to dashboard Cite

Menkes disease is an effect of ATP7A gene mutation in humans, coding the Cu-ATP-ase which is essential in intestinal copper absorption and its subsequent transfer to circulation. This mutation results in a deficiency of copper in all tissues except the epithelia of intestine and kidney tubules. Subcutaneous injection of copper ions is the main therapy for Menkes patients. Mosaic (Atp7a(mo-ms)) mice closely simulate the situation in Menkes disease. The aim of this study was to evaluate the changes in structure and element content in kidneys of mosaic mice after copper supplementation. Hematoxylin-eosin staining was used to analyze tissue morphology and atomic absorption spectrometry to estimate Cu and Zn content. X-ray microanalysis was performed to measure Na, Mg, P, Cl, and K content in the cells of the proximal and distal tubules. Copper administration lengthened the lifespan of the mutants but led to its high accumulation and results in severe kidney damage. Karyomegalia, necrosis of tubular and Bowman's capsule epithelium, lesions, and atrophy of glomeruli were observed in the treated mutants. Copper treatment afterwards led to sclerosis of glomeruli and tubules enhanced proliferation of epithelial cells and formation of both polycystic and papillary carcinoma patterns in kidney. We suggest that copper excess may impair the activity of Na(+)/K(+) ATP-ase in renal tubules of ms/- males. The content of Mg, P, and Cl in kidneys in mutants was also changed after copper administration.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Copper Supplementation on the Structure and Content of Elements in Kidneys of Mosaic Mutant Mice

Lenartowicz

Windak

Tylko

et al. 2009

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Jankowski et al [193] demonstrated in an in vitro study on rat embryos that Cu is essential for early embryonic development. The fetus is sensitive to a lack of Cu, which may lead to irreversible changes in the nervous system [194,195]. Meta-analysis by Lewandowska et al [196] showed that reduced serum Cu levels at the beginning of pregnancy were associated with a higher risk of pregnancy-induced hypertension.…”

Section: Copper (Cu)mentioning

confidence: 99%

The Role of Fe, Zn, and Cu in Pregnancy

2020

View full text Add to dashboard Cite

Iron (Fe), copper (Cu), and zinc (Zn) are microelements essential for the proper functioning of living organisms. These elements participatein many processes, including cellular metabolism and antioxidant and anti-inflammatory defenses, and also influence enzyme activity, regulate gene expression, and take part in protein synthesis. Fe, Cu, and Zn have a significant impact on the health of pregnant women and in the development of the fetus, as well as on the health of the newborn. A proper concentration of these elements in the body of women during pregnancy reduces the risk of complications such as anemia, induced hypertension, low birth weight, preeclampsia, and postnatal complications. The interactions between Fe, Cu, and Zn influence their availability due to their similar physicochemical properties. This most often occurs during intestinal absorption, where metal ions compete for binding sites with transport compounds. Additionally, the relationships between these ions have a great influence on the course of reactions in the tissues, as well as on their excretion, which can be stimulated or delayed. This review aims to summarize reports on the influence of Fe, Cu, and Zn on the course of single and multiple pregnancies, and to discuss the interdependencies and mechanisms occurring between Fe, Cu, and Zn.

show abstract

“…This characteristic is required for function but also leads to potentially toxic environments if levels are too high. Both cuprous ion and ferrous ion react vigorously with hydrogen peroxide to form hydroxyl radical (Prohaska, 1997). Thus, mammalian cells contain exquisite protein machinery to facilitate transport (Fe) and excretion (Cu) to maintain homeostasis (Prohaska, 2006;Andrews and Schmidt, 2007).…”

Section: Introductionmentioning

confidence: 99%

Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels

Pyatskowit

Prohaska

2008

Comparative Biochemistry and Physiology Part C: Toxicology &

Self Cite

View full text Add to dashboard Cite

Iron homeostasis depends on adequate dietary copper but the mechanisms are unknown. Mice (Mus musculus) and rat (Rattus norvegicus) offspring were compared to determine the effect of dietary copper deficiency (Cu-) on iron status of plasma, liver, brain and intestine. Holtzman rat and Hsd:ICR (CD-1) outbred albino mouse dams were fed a Cu-diet and drank deionized water or Cu supplemented water. Offspring were sampled at time points between postnatal ages 13 and 32. Curat and mouse pups were both anemic, but only rat pups had lower plasma and brain iron levels. Plasma iron was lower throughout the suckling period in Cu-rats but not Cu-mice. Cu-mice derived from dams restricted of Cu only during lactation were also severely anemic without hypoferremia. Intestinal metal analysis confirmed that Cu-pups had major reductions in intestinal concentration of Cu, increased Fe, and normal Zn. However, whole mouse (less the intestine) analysis demonstrated normal content of Fe indicating that the limitation in iron transport by intestinal hephaestin had no consequence to total iron reserves of the mouse. Further research will be needed to determine the reason Cu-mice were anemic since the "ferroxidase" hypothesis does not explain this phenotype.

show abstract

Neurochemical Roles of Copper as Antioxidant or Prooxidant

Cited by 6 publications

References 80 publications

Effects of Copper Supplementation on the Structure and Content of Elements in Kidneys of Mosaic Mutant Mice

Effects of Copper Supplementation on the Structure and Content of Elements in Kidneys of Mosaic Mutant Mice

The Role of Fe, Zn, and Cu in Pregnancy

Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels

Contact Info

Product

Resources

About