Neurochemical phenotypes of huntingtin-associated protein 1 in reference to secretomotor and vasodilator neurons in the submucosal plexuses of rodent small intestine

Tarif, Abu Md Mamun; Islam, Md Nabiul; Jahan, Mir Rubayet; Afrin, Marya; Meher, Mirza Mienur; Nozaki, Kanako; Masumoto, Kouji; Yanai, Akie; Shinoda, Koh

doi:10.1016/j.neures.2022.12.023

Cited by 3 publications

(5 citation statements)

References 63 publications

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“…HAP1 is highly expressed in nociceptive/ proprioceptive neurons, which suggests that it plays an important role in pain transduction and proprioception. HAP1 is also expressed in the rodent enteric nervous system, and though its expression does not differ between different intestinal segments, it is more highly expressed in rats than in mice (Tarif et al, 2023). In the submucosal nerve plexus, HAP1 is expressed in secretomotor and vasodilator neurons (Tarif et al, 2023), whereas in the myenteric nerve plexus, HAP1 is predominantly expressed in motor neurons (Tarif et al, 2021).…”

Section: Peripheral Nervous Systemmentioning

confidence: 99%

“…HAP1 is also expressed in the rodent enteric nervous system, and though its expression does not differ between different intestinal segments, it is more highly expressed in rats than in mice (Tarif et al, 2023). In the submucosal nerve plexus, HAP1 is expressed in secretomotor and vasodilator neurons (Tarif et al, 2023), whereas in the myenteric nerve plexus, HAP1 is predominantly expressed in motor neurons (Tarif et al, 2021). The detailed distribution of HAP1 in the peripheral nervous system (PNS) is shown in Table 2.…”

Section: Peripheral Nervous Systemmentioning

confidence: 99%

“…Dorsal root ganglion Neurons Moderate Rat; mouse (Islam et al, 2020;Pan et al, 2023) Intralingual ganglion Neurons Abundant distribution Mouse (Islam et al, 2023) Lingual root ganglion Neurons Abundant distribution Mouse (Islam et al, 2023) Submucosal nerve plexus Neurons High Rat; mouse (Tarif et al, 2023) Myenteric nerve plexus Neurons High Rat; mouse (Tarif et al, 2021) Abdominal sympathetic ganglia Neurons Extremely low Mouse (Dragatsis et al, 2000) Intestinal neurons Neurons Extremely low Mouse (Dragatsis et al, 2000) The gastrointestinal tract is an important part of the endocrine system. A study of rat pyloric glands revealed that HAP1 is specifically expressed in gastrin (G) cells (Yanai et al, 2020), which are neuroendocrine cells responsible for gastrin synthesis and secretion (Schubert, 2016), suggesting the possible involvement of HAP1 in the regulation of gastrin secretion.…”

Section: Location Tissues or Cells Expression Level Resourcesmentioning

confidence: 99%

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Research advances in huntingtin-associated protein 1 and its application prospects in diseases

Wu,

Wang,

et al. 2024

Front. Neurosci.

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Huntingtin-associated protein 1 (HAP1) was the first protein discovered to interact with huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion, endocrine, and digestive systems. HAP1 has diverse functions involving in vesicular transport, receptor recycling, gene transcription, and signal transduction. HAP1 is strongly linked to several neurological diseases, including Huntington’s disease, Alzheimer’s disease, epilepsy, ischemic stroke, and depression. In addition, HAP1 has been proved to participate in cancers and diabetes mellitus. This article provides an overview of HAP1 regarding the tissue distribution, cell localization, functions, and offers fresh perspectives to investigate its role in diseases.

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Section: Peripheral Nervous Systemmentioning

confidence: 99%

Section: Peripheral Nervous Systemmentioning

confidence: 99%

Section: Location Tissues or Cells Expression Level Resourcesmentioning

confidence: 99%

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Research advances in huntingtin-associated protein 1 and its application prospects in diseases

Wu,

Wang,

et al. 2024

Front. Neurosci.

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“…In addition to central nervous system (CNS), HAP1 is also present in the enteric nervous system (ENS) ( Tarif and Islam, 2021 ; Tarif et al, 2022 ) that is embedded in the wall of the gastrointestinal tract and contains polarized neural circuits responsible for controlling a wide variety of gastrointestinal functions ( Furness et al, 2014 ). The ENS, sharing many features with the brain, can act as a potential portal for pathogenesis of NDs and is also a neurodegenerative target ( Chalazonitis and Rao, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

“…The ENS, sharing many features with the brain, can act as a potential portal for pathogenesis of NDs and is also a neurodegenerative target ( Chalazonitis and Rao, 2018 ). HAP1 is abundantly expressed in excitatory and inhibitory motor neurons of myenteric plexuses, and secretomotor and vasodilator neurons of submucosal plexuses ( Tarif and Islam, 2021 ; Tarif et al, 2022 ). The fact suggests that HAP1-associated intracellular trafficking plays an important role in these neurons of ENS.…”

Section: Introductionmentioning

confidence: 99%

Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases

Chen

et al. 2023

Front. Aging Neurosci.

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Huntingtin-associated protein 1 (HAP1), the first identified HTT-binding partner, is highly expressed in the central nervous system, and has been found to associated with neurological diseases. Mounting evidence suggests that HAP1 functions as a component of cargo-motor molecules to bind various proteins and participates in intracellular trafficking. It is known that the failure of intracellular transport is a key contributor to the progression of neurodegenerative disorders (NDs) including Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), spinal and bulbar muscular atrophy (SBMA) and spinocerebellar ataxia (SCA). The link between HAP1 and various NDs is supported by growing evidence. This review aims to provide a comprehensive overview of the intracellular trafficking function of HAP1 and its involvement in NDs.

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Immunohistochemical Distribution and Neurochemical Characterization of Huntingtin-Associated Protein 1 Immunoreactive Neurons in the Adult Mouse Lingual Ganglia

et al. 2023

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Huntingtin-associated protein 1 (HAP1) is a determinant marker for the stigmoid body (STB), a neurocytoplasmic physiological inclusion. STB/HAP1 enriched areas in the brain/spinal cord are usually protected from neurodegenerative diseases, whereas the regions with tiny amounts or no STB/HAP1 are affected. In addition to the brain/spinal cord, HAP1 is highly expressed in the myenteric/submucosal plexuses of the enteric nervous system in the gastrointestinal tract. The tongue is attached to the pharynx by the hyoid bone as an extension of the gastrointestinal system. To date, the immunohistochemical distribution and neurochemical characterization of HAP1 have not been elucidated in the lingual ganglia. Using immunohistochemistry and light microscopy, our current study demonstrates the expression and immunohistochemical phenotype of HAP1 in the lingual ganglia of adult mice. We showed that HAP1 was profoundly distributed in the intralingual ganglion (ILG) and the ganglia near the root of the tongue (which we coined as “lingual root ganglion”; LRG). Neurons in ILG and LRG exhibited high coexpression of HAP1 with NOS or ChAT. Furthermore, most HAP1-immunoreactive neurons contained SP, CGRP, and VIP immunoreactivity in both ILG and LRG. The current results might serve as an essential base for future studies to elucidate the pathological/physiological functions of HAP1 in the lingual ganglia.

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Neurochemical phenotypes of huntingtin-associated protein 1 in reference to secretomotor and vasodilator neurons in the submucosal plexuses of rodent small intestine

Cited by 3 publications

References 63 publications

Research advances in huntingtin-associated protein 1 and its application prospects in diseases

Research advances in huntingtin-associated protein 1 and its application prospects in diseases

Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases

Immunohistochemical Distribution and Neurochemical Characterization of Huntingtin-Associated Protein 1 Immunoreactive Neurons in the Adult Mouse Lingual Ganglia

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