2023
DOI: 10.1016/j.neures.2022.12.023
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Neurochemical phenotypes of huntingtin-associated protein 1 in reference to secretomotor and vasodilator neurons in the submucosal plexuses of rodent small intestine

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Cited by 3 publications
(5 citation statements)
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“…HAP1 is highly expressed in nociceptive/ proprioceptive neurons, which suggests that it plays an important role in pain transduction and proprioception. HAP1 is also expressed in the rodent enteric nervous system, and though its expression does not differ between different intestinal segments, it is more highly expressed in rats than in mice (Tarif et al, 2023). In the submucosal nerve plexus, HAP1 is expressed in secretomotor and vasodilator neurons (Tarif et al, 2023), whereas in the myenteric nerve plexus, HAP1 is predominantly expressed in motor neurons (Tarif et al, 2021).…”
Section: Peripheral Nervous Systemmentioning
confidence: 99%
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“…HAP1 is highly expressed in nociceptive/ proprioceptive neurons, which suggests that it plays an important role in pain transduction and proprioception. HAP1 is also expressed in the rodent enteric nervous system, and though its expression does not differ between different intestinal segments, it is more highly expressed in rats than in mice (Tarif et al, 2023). In the submucosal nerve plexus, HAP1 is expressed in secretomotor and vasodilator neurons (Tarif et al, 2023), whereas in the myenteric nerve plexus, HAP1 is predominantly expressed in motor neurons (Tarif et al, 2021).…”
Section: Peripheral Nervous Systemmentioning
confidence: 99%
“…HAP1 is also expressed in the rodent enteric nervous system, and though its expression does not differ between different intestinal segments, it is more highly expressed in rats than in mice (Tarif et al, 2023). In the submucosal nerve plexus, HAP1 is expressed in secretomotor and vasodilator neurons (Tarif et al, 2023), whereas in the myenteric nerve plexus, HAP1 is predominantly expressed in motor neurons (Tarif et al, 2021). The detailed distribution of HAP1 in the peripheral nervous system (PNS) is shown in Table 2.…”
Section: Peripheral Nervous Systemmentioning
confidence: 99%
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“…In addition to central nervous system (CNS), HAP1 is also present in the enteric nervous system (ENS) ( Tarif and Islam, 2021 ; Tarif et al, 2022 ) that is embedded in the wall of the gastrointestinal tract and contains polarized neural circuits responsible for controlling a wide variety of gastrointestinal functions ( Furness et al, 2014 ). The ENS, sharing many features with the brain, can act as a potential portal for pathogenesis of NDs and is also a neurodegenerative target ( Chalazonitis and Rao, 2018 ).…”
Section: Introductionmentioning
confidence: 99%
“…The ENS, sharing many features with the brain, can act as a potential portal for pathogenesis of NDs and is also a neurodegenerative target ( Chalazonitis and Rao, 2018 ). HAP1 is abundantly expressed in excitatory and inhibitory motor neurons of myenteric plexuses, and secretomotor and vasodilator neurons of submucosal plexuses ( Tarif and Islam, 2021 ; Tarif et al, 2022 ). The fact suggests that HAP1-associated intracellular trafficking plays an important role in these neurons of ENS.…”
Section: Introductionmentioning
confidence: 99%