Neurochemical organization of the macaque striate cortex: Correlation of cytochrome oxidase with Na+K+ATPase, NADPH-diaphorase, nitric oxide synthase, and N-methyl-d-aspartate receptor subunit 1

Ultrahigh field magnetic resonance imaging and spectroscopy

“…CMRO 2 increases must occur through increased activity of the mitochondria in the "activated" neurons. The mitochondrial density is high in the synapse rich regions, predominantly in the dendrites [70]. It might be possible to image CMRO 2 increases directly using the magnetic isotope of oxygen ( 17 O) (e.g, [71][72][73] and references therein).…”

How accurate is magnetic resonance imaging of brain function?

“…Increases in CMRO 2 must occur through increased activity of the mitochondria in the 'activated' neurons and the mitochondrial density is high in the synapse-rich regions, predominantly in the dendrites [45]. It might be possible in the future to image CMRO 2 increases directly using the magnetic isotope of oxygen ( 17 O; Refs [46 -48] and Refs therein).…”

Increased Vulnerability to Depressive-Like Behavior of Mice with Decreased Expression of VGLUT1

“…Garcia-Garcia et al, which is highly regulated by glutamatergic neurotransmission (18,19) was studied by 13 C magnetic resonance spectroscopy ( 13 C-MRS) and cytochrome oxidase histochemistry respectively. Secondly, we studied how neurotransmitter levels, the expression of presynaptic proteins involved in the glutamate/GABA cycle as well as behaviour could be influenced by genotype (VGLUT1+/-mice), the environmental model of depression chronic mild stress (CMS) and by the interaction between both.…”