Neurochemical effects of 5-HT1 receptor ligands in pigeons

Gleeson, Suzanne; Weissman, Ben Avi; Seggel, Mark R.; Barrett, James E.

doi:10.1016/0014-2999(92)90543-d

Cited by 17 publications

(10 citation statements)

References 27 publications

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“…In pigeons, systemic injection of DPAT decreases the levels of 5-HIAA (a 5-HT metabolite) but does not change the levels of other monoaminergic metabolites in the cerebrospinal fluid (CSF) [22,23,83], suggesting that in this species, this 5-HT 1AR agonist decreases the activity of 5-HTergic neurons. The 5-HIAA levels in the mammalian ventricular CSF have been shown to reliably indicate serotonergic activity in the brain (e.g., [84]).…”

Section: Discussionmentioning

confidence: 99%

“…Similar to mammals, systemic DPAT injection reduces serotonergic neurotransmission in pigeons [22][23][24]24], possibly by acting on inhibitory 5-HT 1A autoreceptor-mediated mechanisms, similar to those found in mammals. Accordingly, pretreatment with a 5-HT 1AR antagonist, such as WAY100635 decreases drinking and sleep behaviors induced by ICV 5-HT injection and antagonizes DPAT-induced feeding and drinking behaviors [13].…”

Section: Introductionmentioning

confidence: 93%

“…The animals from group DHT12 were used to verify the effects of 5,7-DHT on the 5-HT levels at the 12th day after 5,7-DHT treatment. The animals from group DHT28 were subjected to pharmacological experiments (from day [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] to evaluate the effects of 5,7-DHT on the ingestive and behavioral responses produced by 5-HT and DPAT (according to protocols similar to those described above). Each animal in the group DHT28 were evaluated using all drugs (7-day interval between treatments).…”

Section: Effects Of the Neurotoxin 57-dht On The Ingestive And Behavmentioning

confidence: 99%

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Distribution of serotonin 5-HT 1A -binding sites in the brainstem and the hypothalamus, and their roles in 5-HT-induced sleep and ingestive behaviors in rock pigeons ( Columba livia )

Santos

Krüger

Melleu

et al. 2015

Behavioural Brain Research

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Section: Effects Of the Neurotoxin 57-dht On The Ingestive And Behavmentioning

confidence: 99%

See 1 more Smart Citation

Distribution of serotonin 5-HT 1A -binding sites in the brainstem and the hypothalamus, and their roles in 5-HT-induced sleep and ingestive behaviors in rock pigeons ( Columba livia )

Santos

Krüger

Melleu

et al. 2015

Behavioural Brain Research

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“…The unexpected lack of effect of the 5-HT 1A agonist in B. gauderio is nevertheless relevant because: (1) it is the first report to our knowledge in which the administration of 5-HT 1A receptor agonists do not affect aggression in realistic dyadic encounters; and (2) it strengthens the body of data that show interspecific differences in the organization of the 5-HT system. Even if the presence of 5-HT 1A receptors has been documented in fish, amphibians, reptiles, and birds (Palacios and Dietl, 1988; Gleeson et al, 1992; Lima et al, 1992; Khan et al, 1996; Winberg and Nilsson, 1996; Marracci et al, 1997; Norton et al, 2008), a comparative analysis of the degree of conservation of the receptor across taxa has not been performed. However, in both, Danio rerio and Xenopus laevis , the 5-HT 1A receptors show an overall amino-acid identity of 78 and 73% respectively compared to the mammal receptor (Marracci et al, 1997; Norton et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Differential serotonergic modulation of two types of aggression in weakly electric fish

Zubizarreta¹,

Perrone²,

Stoddard³

et al. 2012

Front. Behav. Neurosci.

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Agonistic aggression has provided an excellent framework to study how conserved circuits and neurochemical mediators control species-specific and context-dependent behavior. The principal inhibitory control upon aggression is serotonin (5-HT) dependent, and the activation of 5-HT1A receptors is involved in its action. To address whether the serotonergic system differentially regulates different types of aggression, we used two species of weakly electric fish: the solitary Gymnotus omarorum and the gregarious Brachyhypopomus gauderio, which display distinctive types of aggression as part of each species' natural behavioral repertoire. We found that in the reproduction-related aggression displayed by B. gauderio after conflict resolution, the serotonergic activity follows the classic pattern in which subordinates exhibit higher 5-HT levels than controls. After the territorial aggression displayed by G. omarorum, however, both dominants and subordinates show lower 5-HT levels than controls, indicating a different response of the serotonergic system. Further, we found interspecific differences in basal serotonin turnover and in the dynamic profile of the changes in 5-HT levels from pre-contest to post-contest. Finally, we found the expected reduction of aggression and outcome shift in the territorial aggression of G. omarorum after 8-OH-DPAT (5-HT1A receptor agonist) administration, but no effect in the reproduction-related aggression of B. gauderio. Our results demonstrate the differential participation of the serotonergic system in the modulation of two types of aggression that we speculate may be a general strategy of the neuroendocrine control of aggression across vertebrates.

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“…The topographic and functional organization of the serotonergic system in birds maintained homologies with reptiles and mammals (Dubé & Parent, 1981;Parent, 1981;Parent et al, 1981;Duchala et al, 1984;Sako et al, 1986;Cozzi et al, 1991;Challet et al, 1996;Gruss & Braun, 1997). However, studies about the participation of serotonin receptors in the feeding behavior of quails (Coturnix japonica) are absent from the literature, although receptors for serotonin have been identified in bird brains (Gleeson et al, 1992;Saadoun & Cabrera, 2002).…”

Section: Introductionmentioning

confidence: 95%

Influence of 5-HT1A agonist on the feeding behavior of Coturnix japonica (Galliformes: Aves)

Reis¹,

Marinho

2005

Braz. J. Biol.

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In this study, we investigate the effect of serotonin receptor 5-HT1A stimulation on the feeding behavior of quails (Coturnix japonica). The administration of 5-HT1A agonist, 8-OH-DPAT (0.05 to 5.0 mg/Kg) dose-dependently inhibited the food intake in normally fed quails. Greater inhibition was attained with 5.0 mg/kg (0.93 ± 0.21 g vs. 5.83 ± 0.25 g, P < 0.05, 2 h after food offer). A comparable response was obtained from previously fasted quails. At end of 2 h, a higher dose of 8-OH-DPAT induced more intense hypophagy (1.59 ± 0.41 g vs. 6.85 ± 1.04 g, P < 0.0001). Previous treatment with the antagonist 5-HT1A/β-adrenergic, propranolol, failed to block the inhibitory action of 8-OH-DPAT, but instead, intensified it (controls, 5.22 ± 1.09 g; 8-OH-DPAT, 1.41 ± 0.19 g; propranolol + 8-OH-DPAT, 0.44 ± 0.25 g, P < 0.01, for all comparisons). The administration of an isolated higher dose of propranolol induced a hypophagic action (controls, 4.5 ± 0.8 g vs. propranolol, 2.0 ± 0.2 g, P < 0.01). Current outcomes suggest a possible role of 5-HT1A receptor on the feeding behavior of quails, as opposed to mammals. On the other hand, the intensified hypophagy induced by previous administration of propranolol raises the hypothesis of a β-adrenergic excitatory mechanism that controls the feeding behavior of quails.Keywords: feeding behavior, 5-HT1A receptor, serotonergic system, quails, Coturnix japonica. 5,83 ± 0,25 g, P < 0,05, 2 h após a oferta de alimento). Resposta comparável foi alcançada nas aves previamente submetidas ao jejum alimentar. Ao final de 2 h, a dose maior de 8-OH-DPAT induziu a uma intensa resposta hipofágica (1,59 ± 0,41 g vs. 6,85 ± 1,04 g, P < 0,0001). O tratamento prévio com o antagonista 5-HT1A/β-adrenérgico, propranolol, não bloqueou a ação inibidora do 8-OH-DPAT na ingestão alimentar, ao contrário, intensificou-a (controles, 5,22 ± 1,09 g; 8-OH-DPAT, 1,41 ± 0,19 g; propranolol + 8-OH-DPAT, 0,44 ± 0,25 g, P < 0,01, para todas as comparações). A administração isolada de propranolol evidenciou uma ação hipofágica com a dose maior (controles, 4,5 ± 0,8 g vs. propranolol, 2,0 ± 0,2 g, P < 0,01). Os resultados obtidos evidenciaram um possível papel dos receptores 5-HT1A na modulação do comportamento alimentar em codornas de natureza oposta ao referido para mamíferos. Por outro lado, a potencialização da hipofagia pela prévia administração de propranolol suscita a hipótese de um mecanismo β-adrenérgico excitatório no controle do comportamento alimentar em codornas. RESUMO

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Neurochemical effects of 5-HT1 receptor ligands in pigeons

Cited by 17 publications

References 27 publications

Distribution of serotonin 5-HT 1A -binding sites in the brainstem and the hypothalamus, and their roles in 5-HT-induced sleep and ingestive behaviors in rock pigeons ( Columba livia )

Distribution of serotonin 5-HT 1A -binding sites in the brainstem and the hypothalamus, and their roles in 5-HT-induced sleep and ingestive behaviors in rock pigeons ( Columba livia )

Differential serotonergic modulation of two types of aggression in weakly electric fish

Influence of 5-HT1A agonist on the feeding behavior of Coturnix japonica (Galliformes: Aves)

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