Neurochemical differences between bipolar disorder type I and II in superior temporal cortices: A proton magnetic resonance spectroscopy study

Atagün, Murat İlhan; Sikoglu, Elif; Can, Serdar Süleyman; Uğurlu, Görkem Karakaş; Kaymak, Semra Ulusoy; Çayköylü, Ali; Algın, Oktay; Phillips, Mary L.; Moore, Constance M.; Öngür, Döst

doi:10.1016/j.jad.2018.04.010

Cited by 37 publications

(28 citation statements)

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“…This study aimed to clarify the relationship of circulating PTE and/or PLE levels with the pathophysiology of BP. Moreover, a number of previous studies examining neurochemical differences between BP I and II, hinted at the possibility that molecularly‐based qualitative differences might underlie phenotypic differences between BP types I and II. This assumption prompted us to conduct subgroup analyses of BP I‐ and BP II patients.…”

mentioning

confidence: 99%

Altered ethanolamine plasmalogen and phosphatidylethanolamine levels in blood plasma of patients with bipolar disorder

Ogawa

Hattori

Ota

et al. 2020

Psychiatry Clin Neurosci

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Aim Ethanolamine‐containing phospholipids are synthesized in endoplasmic reticulum (ER) and mitochondria. ER stress and mitochondrial dysfunction have been implicated in bipolar disorder (BP). In this study, we aimed to examine the relationship of ethanolamine plasmalogen (PLE) and phosphatidylethanolamine (PTE) levels in blood plasma with BP. Methods Plasma PLE and PTE levels were compared between 34 patients with BP (DSM‐IV) and 38 healthy control participants matched for age, sex, and ethnicity (Japanese). Furthermore, the relationships of plasma PLE and PTE levels with clinical variables were explored. Results Plasma PLE levels were significantly lower in patients with BP than in healthy controls (P = 0.0033). In subgroup analyses, plasma PLE levels were significantly lower in patients with BP type I (BP I) than in healthy controls (P = 0.0047); furthermore, plasma PTE levels were significantly lower in patients with BP I than in controls (P = 0.016) and patients with BP type II (BP II) (P = 0.010). Receiver‐operating characteristic curve analysis revealed that the discriminatory power of plasma PTE levels for distinguishing between BP I and II was fair (area under the curve = 0.78; P = 0.0095). There were no significant correlations of plasma PLE or PTE levels with depression or manic symptoms in patients. Conclusions Plasma PLE and PTE levels were associated with BP I, but not with BP II. Moreover, plasma PTE levels differed between patients with BP I and II. Our findings highlight the importance of ethanolamine phospholipids in the pathophysiology of BP, especially BP I.

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mentioning

confidence: 99%

Altered ethanolamine plasmalogen and phosphatidylethanolamine levels in blood plasma of patients with bipolar disorder

Ogawa

Hattori

Ota

et al. 2020

Psychiatry Clin Neurosci

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“…However, type I patients with BD had significantly lower levels of Glu, Glx, mI, Cr, and NAA in the left hemisphere STL compared with the type II BD and healthy control groups. In addition, patients with a history of psychosis had lower metabolite levels compared with the patients who had no history of psychotic episodes in this study (Atagun et al, 2018). These findings show that the STL is a critical region for psychosis dimension in BD.…”

Section: Neurochemistry Of Auditory Cortices In Bipolar Disordersupporting

confidence: 51%

“…Second, I investigated GABA levels in patients with schizophrenia and BD in Chapter 8 (Atagun et al, 2018).…”

Section: In Vivo Neurochemistry Of Superior Temporal Lobes In Patientmentioning

confidence: 99%

Cognitive Neurophysiology and in vivo Neurochemistry of Bipolar Disorder

Atagün¹

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People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal. Contents CHAPTER 1 Introduction CHAPTER 2 Decrease Of Theta Response In Euthymic Bipolar Patients During An Oddball Paradigm CHAPTER 3 Decrease of Event-Related Delta Oscillations in Euthymic Patients with Bipolar Disorder CHAPTER 4 Lithium Excessively Enhances Event Related Beta Oscillations in Patients with Bipolar Disorder CHAPTER 5 Meta-analysis of Auditory P50 Sensory Gating in Schizophrenia and Bipolar Disorder CHAPTER 6 Investigation of Heschl's gyrus and planum temporale in patients with schizophrenia and bipolar disorder: A proton magnetic resonance spectroscopy study CHAPTER 7 Neurochemical Differences Between Bipolar Disorder Type I and II in Superior Temporal Cortices: A Proton Magnetic Resonance Spectroscopy Study CHAPTER 8 Perisylvian GABA levels in schizophrenia and bipolar disorder CHAPTER 9 Discussion CHAPTER 10 Summary CHAPTER 11 Valorization Acknowledgement Curriculum Vitae List of Publications viii _______________________________________ CHAPTER 1 _______________________________________ Cognitive function can be examined through studying the EEG evaluation and response processes instigated by specific tasks that artificially produce an environmental stimulus. The task may be designed to provoke either a cognitive (top-down operation) or an automatic (bottom-up) processing. Bottom-up (stimulus-driven) tasks (i.e. mismatch negativity [MMN], auditory steady-state response (ASSR) or dual-click paradigm [P50]) are independent of performance and available for all clinical populations. In contrast, top-down tasks rely on mental operations on sensory or cognitive information. Top-down tasks are associated with attention, decision making, and working memory and these functions are performed by complex networks consisting of prefrontal, parietal and temporal cortices (Wagner et al., 1998). Each stimulus of the cognitive tasks induces changes in specific brain waves, either in their magnitudes or phases. Moreover, maintenance of specific frequency bands across trials with respect to an event indicates consistent and quant...

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“…However, despite these limitations, 1 H-MRS is becoming increasingly clinically relevant and is also contributing to our understanding of brain diseases such as Parkinson’s disease [ 3 ], multiple sclerosis [ 4 ], and epilepsy [ 5 ]. Similarly, 1 H-MRS is helping to uncover pathologies in neuropsychiatric illnesses such as schizophrenia [ 6 , 7 ], bipolar disorder [ 8 , 9 ], and anxiety [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

A comprehensive regional neurochemical theory in depression: a protocol for the systematic review and meta-analysis of 1H-MRS studies in major depressive disorder

et al. 2018

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BackgroundMagnetic resonance spectroscopy (MRS) is a non-invasive analytical technique that investigates the presence and concentrations of brain metabolites. In the context of major depressive disorder (MDD), MRS has revealed regional biochemical changes in GABA, glutamate, and choline across different brain compartments. Technical and methodological advances in MRS data acquisition, in particular proton-based 1H-MRS, have resulted in a significant increase in the incidence of reports utilizing the technique for psychiatric disorder research and diagnosis. The most recent comprehensive meta-analysis reviewing MRS in MDD stems from 2006. Using contemporary systemic reviews and meta-analysis, the aim is to first test a neurochemical circuit-based theory of depression and then to determine if clinical scores relate to metabolite concentrations before and during treatment.MethodsRegion-specific metabolite changes in MDD will be assessed by systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Inclusion criteria will include participant age (18 to 65), English language studies, known regions of interest, and detailed documentation of 1H-MRS procedures. Reported brain regions will be standardized according neuroanatomical expertise allowing increased power of the meta-analysis. Regions of interest will initially include the hippocampus, thalamus, prefrontal cortex, anterior and posterior cingulate gyri, parietal lobe, and basal ganglia. Exclusion criteria will include comorbid psychiatric illness and drug use. Two independent reviewers will undertake all data extraction, while a third reviewer will check for reviewer discrepancies. Statistical analysis will be performed using STATA supplemented by Metan software and SPSS.DiscussionThis data will shed new light on the biochemical basis of depression in different brain regions, thereby highlighting the potential of MRS in identifying biomarkers and generating models of MDD and treatment response.Systematic review registrationPROSPERO CRD42018091494

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Neurochemical differences between bipolar disorder type I and II in superior temporal cortices: A proton magnetic resonance spectroscopy study

Cited by 37 publications

References 35 publications

Altered ethanolamine plasmalogen and phosphatidylethanolamine levels in blood plasma of patients with bipolar disorder

Altered ethanolamine plasmalogen and phosphatidylethanolamine levels in blood plasma of patients with bipolar disorder

Cognitive Neurophysiology and in vivo Neurochemistry of Bipolar Disorder

A comprehensive regional neurochemical theory in depression: a protocol for the systematic review and meta-analysis of 1H-MRS studies in major depressive disorder

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