Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats

Penn, Patricia E.; McBride, William J.; Lumeng, Lawrence; Gaff, TM; Li, T.-K.

doi:10.1016/0091-3057(78)90087-4

Cited by 87 publications

(19 citation statements)

References 23 publications

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“…A positive t score indicates a difference between genotypes in the same direction as the drinking difference, while a negative t score indicates a difference between the genotypes in the opposite direction as the drinking difference. (Bachtell et al, 2003;Belknap et al, 1977;Broadbent et al, 1996;Cunningham, 1995a;Grahame and Cunningham, 1997;Meliska et al, 1995;Risinger and Cunningham, 1995) C57BL/6J v BALB/ 2.61 (Froehlich et al, 1988;Murphy et al, 1989;Penn et al, 1978;Ritz et al, 1994;Samson et al, 1998;Schechter, 1992;Stewart et al, 1996) HAD v LAD 26 gen I ++ 10% 5.25 (Ritz et al, 1994;Samson et al, 1998) HAD Alcohol. Author manuscript; available in PMC 2009 February 1.…”

Section: Discussionmentioning

confidence: 99%

Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol?

Green¹,

Grahame²

2008

Alcohol

178

167

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Many studies have used voluntary ethanol consumption by animals to assess the influence of genetic and environmental manipulations on ethanol drinking. However, the relationship between home cage ethanol consumption and more formal assessments of ethanol-reinforced behavior using operant and instrumental conditioning procedures is not always clear. The present review attempted to evaluate whether there are consistent correlations between mouse and rat home cage ethanol drinking on the one hand, and either operant oral self-administration (OSA), conditioned taste aversion (CTA) or conditioned place preference (CPP) with ethanol on the other. We also review literature on intravenous ethanol self-administration (IVSA). To collect data, we evaluated a range of genetic manipulations that can change both genes and ethanol drinking behavior including selective breeding, transgenic and knock-out models, and inbred and recombinant inbred strain panels. For a genetic model to be included in the analysis, there had to be published data resulting in differences on home cage drinking and data for at least one of the other behavioral measures. A consistent, positive correlation was observed between ethanol drinking and OSA, suggesting that instrumental behavior is closely genetically related to consummatory and ingestive behavior directed at ethanol. A negative correlation was observed between CTA and drinking, suggesting that ethanol's aversive actions may limit oral consumption of ethanol. A more modest, positive relationship was observed between drinking and CPP, and there were not enough studies available to determine a relationship with IVSA. That some consistent outcomes were observed between widely disparate behavioral procedures and genetic populations may increase confidence in the validity of findings from these assays. These findings may also have important implications when researchers decide which phenotypes to use in measuring alcohol-reward relevant behaviors in novel animal models.

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Section: Discussionmentioning

confidence: 99%

Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol?

Green¹,

Grahame²

2008

Alcohol

178

167

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“…Additionally, P rats will readily operantly self-administer EtOH. Using a one-lever design procedure, free-fed P rats will exceed 1000 bar presses for EtOH in a 24-hr period (Penn et al, 1978). In a two-lever procedure (EtOH and water) with ad libitum food, P rats will operantly selfadminister greater than 9 g/kg/day of 15 or 20% EtOH (Murphy et al, 1989).…”

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confidence: 99%

Heart Rate and Motor‐Activating Effects of Orally Self‐Administered Ethanol in Alcohol‐Preferring (P) Rats

Bell

Rodd-Henricks

Webster

et al. 2002

Alcoholism Clin & Exp Res

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The data indicate that oral self-administration of EtOH enhances behavioral and autonomic activation, compared with saccharin or water, in adult male P rats and support previous observations that changes in HR can be used as an index of reinforcement. Additionally, it seems that the behavioral and autonomic activation elicited by EtOH self-administration can be conditioned to the environment in which EtOH was self-administered. These findings parallel reports on cued reactivity (behavioral and autonomic activation) in alcoholics exposed to alcohol-associated stimuli.

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“…Specifically, Indiana alcohol-preferring (P) (e.g., Files et al, 1992Files et al, , 1993Murphy et al, 1989;Penn et al, 1978;Ritz et al, 1994a,b;Samson et al, 1998;Schwarz-Stevens et al, 1991), ALKO alcohol-accepting (AA) (Files et al, 1997;Sinclair, 1989, 1990;Ritz et al, 1986Ritz et al, , 1989a, and Indiana high-alcohol-drinking (HAD) (Ritz et al, 1994a,b;Samson et al, 1998) rats have been described to press a lever to obtain pharmacologically relevant amounts of ethanol, in most cases comparable with those consumed under the home cage, two-bottle regimen. In contrast, selectively bred ethanol-nonpreferring Indiana alcoholnonpreferring (NP), ALKO alcohol nonaccepting (ANA), and Indiana low-alcohol-drinking (LAD) rats have been reported to display minimal degrees of lever pressing for ethanol, consistent with their avoidance of the ethanol solutions under the two-bottle paradigm.…”

mentioning

confidence: 99%

Operant Self‐Administration of Ethanol in Sardinian Alcohol‐Preferring Rats

Vacca

Serra

Brunetti

et al. 2002

Alcoholism Clin & Exp Res

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Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats

Cited by 87 publications

References 23 publications

Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol?

Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol?

Heart Rate and Motor‐Activating Effects of Orally Self‐Administered Ethanol in Alcohol‐Preferring (P) Rats

Operant Self‐Administration of Ethanol in Sardinian Alcohol‐Preferring Rats

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