Neurochemical and cellular markers in human cervix of late pregnant, postpartal and non-pregnant women

Stjernholm, Ylva Vladic; Sennström, Maria; Granström, Lena; Ekman, Gunvor; Liang, Yong; Johansson, Ӧlle

doi:10.1034/j.1600-0412.2000.079007528.x

Cited by 10 publications

(17 citation statements)

References 35 publications

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“…Stjemholm et a1. (26) found abundant dendritic cells, positive for HLA-DR and protein S-IOO in the cervix, especially at term, suggesting a general activation of the immune system at late pregnancy and at parturition. This team also studied distribution of PGP 9.5-immunoreactive nerve fibres and cells in cervical biopsies obtained from late pregnant, postpartal and non-pregnant women and presented that the total frequency of PGP 9.5-immunoreactive nerve fibres and cells was the highest in the late pregnant, slightly lower in the postpartal and the lowest in the non-pregnant women (12).…”

Section: Fig 1 Sagittal Section Through the Human Vescico-uterine Smentioning

confidence: 88%

Inflammation and Neurotransmission of the Vescico-Uterine Space in Cesarean Sections

et al. 2013

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Collagen IV and laminin play a key role in regulating stiffness, elasticity and flexibility of the vescico-uterine space (VUS) tissue. The neurotensin (NT), the neuropeptide tyrosine (NPY) and the protein gene product 9.5 (PGP 9.5) possessing vasorelaxation and tissue vascularization activities, play key roles in cervical ripening, scar innervations and pain control. We propose that the integrity of these substances in VUS tissue is compromised after Cesarean section (CS), since wound healing disturbances and pelvic pain, as well as pregnancy and delivery complications, are related with lower uterine segment dysfunctions after CS. Therefore, the contents of collagen IV, laminin, NT, NPY and PGP 9.5 nerve fibres from the VUS tissue samples obtained during the first CS and the repeated CS were comparatively studied. VUS specimens were collected from 104 patients during CS and evaluated by immunohistochemistry. Collagen IV and laminin were mostly found in the vascular membrane bounds and their images were quantitatively evaluated by Quantimet Leica analyzer software. Differences of collagen IV, laminin, NT, NPY and PGP 9.5 values in VUS tissue between the first CS and the repeat CS samples were calculated by Student's Mest. Reduced laminin and increased collagen IV values were observed in the VUS scar tissue after the repeated CS in comparison with those of VUS intact tissue obtained during the first CS. Significantly higher values of nerve fibres, containing NT, NPY and PGP 9.5 were registered in intact VUS tissue samples, respectively 5±0.7, 7±0.6 and 5±0.9 CU, than those of VUS scar tissue samples obtained during the repeated CS, respectively 3±0.6,2±0.4 and 3±0.7 CU (p<0.05). The authors observed increased collagen IV and reduced laminin values after the repeated CS which might be the key signs of inflammatory damage of VUS scar tissue by CS. These findings were strengthened by the registration of decreased NT, NPY and PGP 9.5 values in the same samples, which are important neurotransmitters and are responsible for optimal wound healing, pain control and lower uterine segment functions.

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Section: Fig 1 Sagittal Section Through the Human Vescico-uterine Smentioning

confidence: 88%

Inflammation and Neurotransmission of the Vescico-Uterine Space in Cesarean Sections

et al. 2013

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“…Similarly, parasympathetic innervation was located to the stroma (Lucido et al, 2019; Stjernholm et al, 2000), the myometrium (Kosmas et al, 2020), beneath the epithelium (Stjernholm et al, 2000), and in blood vessel walls (Stjernholm et al, 2000). Finally, sensory innervation was also found in the stroma (Lucido et al, 2019, Stjernholm et al, 2000), beneath the epithelium (Stjernholm et al, 2000), in blood vessel walls (Stjernholm et al, 2000) or near blood vessels (Tingåker et al, 2006). Thus, evidence of the presence of various nerve types was found but was not put into a physiological framework to investigate possible roles.…”

Section: Discussionmentioning

confidence: 99%

“…This study was the first to report on all layers of the cervix, including the perimetrium, myometrium, and endometrium. This provides further information on the innervation of the cervix as they identified sympathetic, parasympathetic, and sensory nerve fibers in all layers of the cervix, in contrast to Stjernholm et al (2000) and Lucido et al (2019) who characterized only the endometrial stroma.…”

Section: Cervix Innervation Determined Via Specific Neuronal Markersmentioning

confidence: 96%

“…It is interesting to note that this study also observed sympathetic innervation in fetuses (n = 2), in which innervation patterns had the same appearance as adults. Stjernholm et al (2000) compared peptidergic innervation between cervical biopsies from non-pregnant, pregnant, and postpartum women using IHC. In non-pregnant women, cervical biopsies (10-20 mm deep) taken from the anterior cervical lip at the 12 o'clock position were assessed for S-100, CGRP, VIP, PHM-27, and NPY.…”

Section: Cervix Innervation Determined Via Specific Neuronal Markersmentioning

confidence: 99%

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The human cervix: Comprehensive review of innervation and clinical significance

et al. 2022

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Detailed knowledge regarding the innervation and histology of the human cervix is crucial given the surgical removal of this tissue for conditions such as cervical dysplasia. Recent evidence implicates the cervix in the sexual response, making it pertinent to characterize this region to elucidate its role. Despite this, literature describing the overall innervation of the cervix from anatomical and histological perspectives is lacking. The aim of this review was to consolidate descriptions pertaining to human cervix innervation and discuss possible mechanisms of dysfunction, as an unintended result of cervix removal. A detailed literature search of relevant articles describing human cervix innervation was conducted. 1597 articles were screened based on the keywords searched. Only 16 articles, containing information regarding specific evidence of the innervation of the human cervix, were included and categorized based on parameters of innervation (method, type, location). The published evidence demonstrates that the human cervix has sympathetic, parasympathetic, and sensory innervation, but does not characterize changes after surgical procedures. Despite the gaps in knowledge, it is relevant that associations linking clinical procedures, involving cervical removal and adverse sexual health outcomes, become an important focus for discussions between physicians and patients. Future work is needed to better detail the affected innervation as well as the neural pathway-specific relationship to symptoms of sexual dysfunction.

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“…(35) Although this is still an emerging area of research that is ripe for further investigation, a few studies have shown that the human cervix is more densely innervated than the uterus and in pregnancy that uterine innervation decreases significantly 30-fold compared to non-pregnant uterine tissue) while the degree of innervation in the cervix remains the same. (36–42)…”

Section: Normal Human Cervical Tissue Structure and Function – The Prmentioning

confidence: 99%

The pathophysiology of human premature cervical remodeling resulting in spontaneous preterm birth: Where are we now?

Vink

Mourad

2017

Seminars in Perinatology

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Approximately one in ten (approximately 500,000) pregnancies results in preterm birth (PTB) annually in the United States. Although we have seen a slight decrease in the U.S. PTB rate between 2007 to 2014, data from 2014 to 2015 shows the preterm birth rate has slightly increased. It is even more intriguing to note that the rate of PTB has not significantly decreased since the 1980s. In order to decrease the rate of spontaneous preterm birth (sPTB), it is imperative that we improve our understanding of normal and abnormal reproductive tissue structure and function and how these tissues interact with each other at a cellular and biochemical level. Since other chapters in this issue will be focusing on the myometrium and fetal membranes, the goal of this chapter is to focus on the compartment of the cervix. We will review the current literature on normal and abnormal human cervical tissue remodeling and identify gaps in knowledge. Our goal is also to introduce a revised paradigm of normal cervical tissue structure and function which will provide novel research opportunities that may ultimately lead to developing safe and effective interventions to significantly decrease the rate and complications of prematurity.

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Neurochemical and cellular markers in human cervix of late pregnant, postpartal and non-pregnant women

Cited by 10 publications

References 35 publications

Inflammation and Neurotransmission of the Vescico-Uterine Space in Cesarean Sections

Inflammation and Neurotransmission of the Vescico-Uterine Space in Cesarean Sections

The human cervix: Comprehensive review of innervation and clinical significance

The pathophysiology of human premature cervical remodeling resulting in spontaneous preterm birth: Where are we now?

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