Neurocardiology: close interaction between heart and brain

Wall, E. E. van der; Gilst, Wiek H. van

doi:10.1007/s12471-012-0369-4

Cited by 46 publications

(15 citation statements)

References 29 publications

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“…Neurocardiology refers to the pathophysiological interplays of the nervous and cardiovascular systems (Van der Wall & Van Gilst, 2012). It is an emerging field in medicine over the last decade.…”

Section: Discussionmentioning

confidence: 99%

The unexpected relationship between electrocardiogram and neurological diseases

Lupu¹

2017

PROSOC

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The relationship between Neurology and Cardiology, as well as Neurocardiology Term is, nowadays, more often promoted. The purpose of this paper was to find an objective connection between these two fields of Medicine. Between January 2015 and April 2015, we hospitalized in the Neurology Department 416 patients. We have considered the demographic data, the neurological diagnosis and paraclinic data (minimum two ECGs, one of the moment of admission and the other later). We studied 416 patients, 213 males and 203 females (51,2 % vs 48,8%). We divided the two groups into other ten groups according to the pathology. The mean group was the Acute Stroke Group (111 males vs. 109 females; 52,13 % vs. 53,69 %). For each group we analyzed the Electrocardiograms. In the males group the Acute Stroke is associated with tachycardia, atrial fibrillation, left axis deviation, flattened T waves, amputated R waves, left ventricle hypertrophy; Chronic Stroke (37 males; 17,37 %) with tachycardia, intermediate axis, flattened T waves, amputated R waves, left ventricle hypertrophy; Intracerebral Acute Hemorrhages (18 males; 8,45 %) with tachycardia, horizontal axis, negative T waves, left ventricle hypertrophy, extrasistolia; TIA (16 males; 7,51 %) with left axis deviation, flattened T waves, amputated R waves, left anterior hemiblock; %) with tachycardia, left axis deviation, flattened T waves. The differences in the females group are: the Acute Stroke is associated with horizontal axis; Chronic Stroke (31 females; 15,27%) with horizontal axis; Dementia ( 22 females; 10,84 %) with tachycardia, left axis deviation; TIA Dementia (12 males; 5,63 %) with bradycardia, horizontal axis, flattened T waves, amputated R waves; Epilepsy (9 males; 4,22 %) with intermediate axis, negative T waves; Parkinson Disease (6 males; 2,81 %) with flattened T waves;Conclusions: Neurology is strong connected with Cardiology. There are some differences between males and females, but Electrocardiogram shows in cases rhythmus, axis, T and R waves abnormalities and left ventricle hypertrophy.

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Section: Discussionmentioning

confidence: 99%

The unexpected relationship between electrocardiogram and neurological diseases

Lupu¹

2017

PROSOC

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“…Our previous study had demonstrated communication between hematopoietic cells and brain cells (including neurons and microglia) in murine models of peripheral inflammation and peripheral arterial disease (Ridder et al, 2014) Given recent attention on the association between ischemic heart disease and neuro-cognitive disorders (Almeida et al, 2012, Lichtman et al, 2008, van der Wall and van Gilst, 2013, we were interested in exploring the role of RBC-EVs as mediators of communication between the periphery and the brain in the context of ischemic heart disease. Images of brains from EpoR-Cre/mTmG mice demonstrated the presence of mGFP +/ Ib1a + microglia in the cerebellum and hippocampus, 4 weeks after I/R (Figure 3F).…”

Section: Rbc-ev-mediated Communication With Brain After I/rmentioning

confidence: 99%

Red blood cell-derived extracellular vesicles mediate intercellular communication in ischemic heart failure

Das

Valkov

Salvador

et al. 2019

Preprint

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Extracellular vesicles (EV) mediate intercellular signaling by transferring their cargo to recipient cells. Red blood cell (RBC)-derived EVs constitute a significant proportion of circulating EVs and have been implicated in regulating immune responses. Here, we describe a transgenic mouse model for fluorescent-based mapping of RBC-EV target cells based on the functional transfer of EV-contained Cre-recombinase to target cells. In a murine model of ischemic heart failure, we detect an increase in RBC-EV-targeted cardiomyocytes in the hearts and microglial cells in the brains. Cells targeted by RBC-EVs present an enrichment of genes implicated in cell proliferation and metabolism pathways compared to non-recombined (non-targeted) cells. Cardiomyocytes targeted by RBC-EVs are more likely to demonstrate cellular markers of DNA synthesis and proliferation, suggesting functional significance of EV-mediated signaling. In conclusion,we leverage our mouse model for mapping of RBC-EV targets in murine ischemic heart failure to demonstrate quantitative and qualitative changes in RBC-EV recipients.

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“…Coronary artery bypass surgery has major effects on neurocognitive functioning [166,167]. Furthermore, chronic vascular and congenital heart disease patients present a peculiar neuroncognitive decline [168]. Exercise stimuli may prevent or slow down the cognitive decline in elderly patients with heart failure [169,170].…”

Section: The Brain-heart Symphonymentioning

confidence: 99%

Coronary microvascular and endothelial function regulation: Crossroads of psychoneuroendocrine immunitary signals and quantum physics [Part A]

Lin¹,

Poretto²,

Scodro³

et al. 2015

J Integr Cardiol

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Nowadays the heart can be considered as a psycho-neuro-endocrine-immunitary structure that constantly interacts with other organs through a dynamic dialogue made of neurotpeptides, hormones and cytokines. The exploration of microvascular function is important as predictive tool and as prognosis of cardiovascular risk and progression of heart failure. This review describes the present knowledge on whether neurotramitters, hormones and cytokines influence microvascular/endothelial function and its genetic and epigenetic background. The review, describing the rich network of connections acting every moment of our lives linking endothelial function to the psychophysical environment, leads then to the description of an endothelial cell functioning, with the look of quantum physics. All this allows to describe some actual scientific methodological and epistemiological problems that remain to be resolved in order to fully understand endothelial function regulation, and future research, prevention and treatment directions. In the end, we describe the "Integrative Medicine" approach (and its beneficial influences on endothelial function regulation) that has emerged as a potential solution to the crisis in the healthcare system of western countries. It provides care that is patient-centered and healing-oriented, stressing the use of treatments originating from both conventional and alternative medicine.

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Neurocardiology: close interaction between heart and brain

Cited by 46 publications

References 29 publications

The unexpected relationship between electrocardiogram and neurological diseases

The unexpected relationship between electrocardiogram and neurological diseases

Red blood cell-derived extracellular vesicles mediate intercellular communication in ischemic heart failure

Coronary microvascular and endothelial function regulation: Crossroads of psychoneuroendocrine immunitary signals and quantum physics [Part A]

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