Neurocan regulates axon initial segment organization and neuronal activity in cultured cortical neurons
David Baidoe-Ansah,
Hadi Mirzapourdelavar,
Stepan Aleshin
et al.
Abstract:The neural extracellular matrix (ECM) accumulates in the form of perineuronal nets (PNNs), particularly around fast-spiking GABAergic interneurons in the cortex and hippocampus, but also in association with the axon initial segments (AIS) and nodes of Ranvier. Increasing evidence highlights the role of Neurocan (Ncan), a brain-specific component of ECM, in the pathophysiology of neuropsychiatric disorders like bipolar disorder and schizophrenia. Ncan localizes at PNNs, nodes of Ranvier and the AIS, highlightin… Show more
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