Neuroblastoma With Symptomatic Spinal Cord Compression at Diagnosis: Treatment and Results  With 76 Cases

Bernardi, Bruno; Pianca, C.; Pistamiglio, Paola; Veneselli, Edvige; Viscardi, Elisabetta; Pession, Andrea; Alvisi, Patrizia; Carli, Modesto; Donfrancesco, Alberto; Casale, Fiorina; Giuliano, Maria; Montezemolo, Luca Cordero di; Cataldo, Andrea Di; Curto, Margherita Lo; Bagnulo, S.; Schumacher, Richard Fabian; Tamburini, Angela; Garaventa, Alberto; Clemente, Luigi; Bruzzi, Paolo

doi:10.1200/jco.2001.19.1.183

Cited by 121 publications

(119 citation statements)

References 18 publications

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“…Five patients with intraspinal masses presented with new symptoms, including scoliosis. De Bernardi et al (24) have reported 40% of survivors of neuroblastoma with spinal cord compression developed late effects, such as scoliosis and sphincteric deficit. Therefore, patients with residual tumors, especially with intraspinal masses, require long-term follow-up.…”

Section: A At Diagnosismentioning

confidence: 99%

Residual tumor in cases of intermediate-risk neuroblastoma did not influence the prognosis

Iehara

Yagyu

Tsuchiya

et al. 2016

Japanese Journal of Clinical Oncology

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Background: It remains unclear whether a residual tumor mass following therapy influences the prognosis of neuroblastoma. Methods: We retrospectively reviewed 20 patients with intermediate-risk tumors treated at our institution between 1993 and 2012 to elucidate whether additional treatment is required for residual tumors. Results: The patient ages at diagnosis ranged from 0 days to 7 years. The 5-year overall survival rate was 94.4%. Thirteen patients had Stage 3 disease and seven patients had Stage 4 disease. Nine patients showed intraspinal extension. Twelve patients had a residual tumor mass at the completion of therapy, and eight showed intraspinal extension. Five of these 12 patients showed metaiodobenzylguanidine (MIBG) uptake at the end of treatment, but the uptake disappeared during the follow-up period. Except for one patient who died due to treatment complications, the rest are all alive, and nine are alive with a residual mass. We examined the residual mass in four patients and found that these tissues had differentiated into a ganglioneuroma or changed to a necrotic tissue. For the three patients with neurological symptoms at the end of treatment, some slight neurological symptoms still remained during the follow-up. Five patients with an intraspinal mass eventually presented with new symptoms. Conclusions: The presence of a residual mass at the end of treatment did not influence the patients' prognosis. Therefore, an invasive radical surgical resection and additional treatment may not be necessary. Cases with a residual intraspinal mass also require a long-term follow-up to assess the neurological prognosis.

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Section: A At Diagnosismentioning

confidence: 99%

Residual tumor in cases of intermediate-risk neuroblastoma did not influence the prognosis

Iehara

Yagyu

Tsuchiya

et al. 2016

Japanese Journal of Clinical Oncology

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“…However, the difference was not statistically significant, and analysis of other prognostic factors was not attempted. In children with newly diagnosed neuroblastoma and SCC, chemotherapy may also be the preferred primary treatment, although there is controversy in the literature [45].…”

Section: The Role Of Chemotherapymentioning

confidence: 99%

“…Chemotherapy may have a role in treating SCC caused by chemosensitive tumors, such as lymphomas [38][39][40][41], leukemia [22,42], germ cell tumors [43,44], and neuroblastoma [45], either in combination with other treatment modalities or on its own. The possibility of using chemotherapy as the primary treatment for SCC in patients with chemosensitive tumors is attractive, as it would avoid the potential morbidity of surgery and provide simultaneous treatment to other foci of systemic disease.…”

Section: The Role Of Chemotherapymentioning

confidence: 99%

Spinal cord compression in cancer patients: Review of diagnosis and treatment

Penas‐Prado

Loghin²

2008

Curr Oncol Rep

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Spinal cord compression (SCC) is a well-known complication in cancer patients, with an enormous potential impact on quality of life. In most cases, treatment is palliative, but a prompt diagnosis and immediate treatment is essential to preserving neurological function. Whereas steroids and radiation have been the mainstay of therapy for many years, the role and timing of surgery has remained controversial. However, class I evidence now exists to support the benefit of pre-irradiation surgical decompression in a carefully selected subpopulation of patients with SCC. A multidisciplinary approach is required to maximize the therapeutic and functional outcome of these patients.

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“…4). Así como en los adultos se consideran distintas opciones terapéuticas, en los niños la primera opción de tratamiento, aparte del tratamiento médico con esteroides, es la administración de quimioterapia ofreciendo la cirugía (laminectomía) en situaciones de inestabilidad ósea y la radioterapia 26,27 en aquellos tumores considerados radiosensibles por las posibles secuelas óseas de ambos tratamientos. Los resultados describen un control del dolor en un 70% (similar en los adultos) con mejoría de la función motora hasta en un 45-60 % (muy superior a la de los adultos donde la incapacidad previa para deambular condiciona los resultados).…”

Section: Síndrome De Compresión Medularunclassified

Radioterapia paliativa en niños: presentación de un caso clínico y recuerdo de sus indicaciones

Zapata¹,

Magallón²,

Valcárcel³

et al. 2004

Oncología (Barc.)

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Resumen• Propósito: conocer el papel de la radioterapia como tratamiento paliativo en la patología oncológica pediátrica.• Caso clínico: se comenta el caso de un niño de 10 años con neuroblastoma estadio IV de inicio que a pesar de sucesivos esquemas de tratamiento por progresión presentó metástasis cerebral única a los tres años del diagnóstico.• Resultados y conclusiones: revisada la literatura, se puede afirmar que la radioterapia es un tratamiento paliativo eficaz y adecuado cuando nuestro objetivo es controlar síntomas y ofrecer calidad de vida.

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Neuroblastoma With Symptomatic Spinal Cord Compression at Diagnosis: Treatment and Results With 76 Cases

Cited by 121 publications

References 18 publications

Residual tumor in cases of intermediate-risk neuroblastoma did not influence the prognosis

Residual tumor in cases of intermediate-risk neuroblastoma did not influence the prognosis

Spinal cord compression in cancer patients: Review of diagnosis and treatment

Radioterapia paliativa en niños: presentación de un caso clínico y recuerdo de sus indicaciones

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