Neuroblastoma stem cells and CFC1

Tsubota, Shoma; Kadomatsu, Kenji

doi:10.18632/oncotarget.18491

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…This novel finding warrants further investigation as, if verified, could provide a potential new method of identifying patients most likely to respond to radiotherapy. Irrespective of these findings, we believe that radiotherapy should be used with caution in infants less than two years old due its numerous short-and longterm adverse effects 22 the activin-CFC1 signaling axis (24,25), semaphorin 3C expression level (26) and mutations in genes such as ALK (anaplastic lymphoma kinase), PTPN11 (protein tyrosine phosphatase, non-receptor type 11), ATRX (ATP-dependent helicase), MYCN (N-myc) and NRAS (N-Ras) (27). Future studies are needed to examine whether these and/or other factors contribute to the effects observed in the present investigation.…”

Section: Discussionmentioning

confidence: 98%

Neuroblastoma Characteristics and Embryonic Origin of The Primary Lesion Site: A SEER Study

Zhu

et al. 2019

Iran J Pediatr

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Background: Neuroblastoma, one of the most prevalent infant malignancies, is heterogeneous and easily spreads into other organs causing life-threatening consequences. Different characters of organs (such as the germ layers where the organs derived from) exert different growth microenvironments and potentially influence the behavior of metastatic neuroblastoma cells and the prognosis of patients. However, limited information is been known about this in neuroblastoma. Objectives: To compare characteristics of neuroblastoma, primarily originating from the same germ layer (the seeds), in different tissues (microenvironment) derived from different germ layers. Methods: We performed retrospective analysis of SEER (Surveillance, Epidemiology, and End Results) data (1973-2014), patients with malignant neuroblastoma were grouped based on the primary lesion site (mesoderm-, ectoderm-or endoderm-derived tissue). Baseline demographic and clinical characteristics were compared between groups. Due to difficulties of processing incomplete SEER data, therapeutic method and survival rates were analyzed using cases from another SEER database (2000-2014). Results: The analysis included 3701 patients: 1970 (53.2%) in the mesoderm group, 1017 (27.5%) in the ectoderm group and 714 (19.3%) in the endoderm group. Tumor histology differed between groups (P < 0.01): the ectoderm group had mostly neuroblastoma (79.2%), as did the mesoderm group (71.1%), whereas the endoderm group contained mainly olfactory neuroblastoma (94.7%). The tumors (mean size: 69.14 ± 58.37 mm) were most commonly poorly differentiated with local extension, although lymph node invasion and distant metastasis occurred in a minority of cases. Compared with the other groups, the endoderm group had smaller (43.89 ± 20.84 mm) and better-differentiated tumors and a lower prevalence of lymph node invasion and metastasis (P < 0.05). Despite this, overall survival was poorest for the endoderm group (P < 0.05). Radiotherapy improved overall survival in the endoderm and ectoderm groups but worsened overall survival in the mesoderm group (P < 0.05). Conclusions: Malignant neuroblastoma characteristics may be influenced by the tumor microenvironment. In the youngest patients, decision-making regarding the best choice of therapy should be delayed until accurate risk stratification is possible.

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Section: Discussionmentioning

confidence: 98%

Neuroblastoma Characteristics and Embryonic Origin of The Primary Lesion Site: A SEER Study

Zhu

et al. 2019

Iran J Pediatr

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“…Although there are no specific individual markers for NC cells or NCSCs[ 4 ], gene expression patterns that identify potential NCSC populations, include VE-cadherin/ CD144, the epidermal growth factor (EGF) family member CFC1/Cripto, transcription factors Pax, Sox10, Hox, mash1, Phox2b; neurotrophic factor receptors p75 NTR , RET and EDNRB, and the nerve-related proteins NF, NC-1, E/C8, HNK1, nestin and α4-integrin. RET expression identifies NCSCs within ganglia and is crucial for vagal NC development, P75 NTR is used widely to purify NCSCs, Sox10 is considered to be a relatively specific and sensitive NCSC marker, and NSCSs in vitro express Sox10, P75 NTR and RET[ 4 , 15 , 52 , 53 ].…”

Section: The Neural Crestmentioning

confidence: 99%

Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting

Farina¹,

Cappabianca²,

Zelli³

et al. 2021

WJSC

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Pediatric neuroblastomas (NBs) are heterogeneous, aggressive, therapy-resistant embryonal tumours that originate from cells of neural crest (NC) origin and in particular neuroblasts committed to the sympathoadrenal progenitor cell lineage. Therapeutic resistance, post-therapeutic relapse and subsequent metastatic NB progression are driven primarily by cancer stem cell (CSC)-like subpopulations, which through their self-renewing capacity, intermittent and slow cell cycles, drug-resistant and reversibly adaptive plastic phenotypes, represent the most important obstacle to improving therapeutic outcomes in unfavourable NBs. In this review, dedicated to NB CSCs and the prospects for their therapeutic eradication, we initiate with brief descriptions of the unique transient vertebrate embryonic NC structure and salient molecular protagonists involved NC induction, specification, epithelial to mesenchymal transition and migratory behaviour, in order to familiarise the reader with the embryonic cellular and molecular origins and background to NB. We follow this by introducing NB and the potential NC-derived stem/progenitor cell origins of NBs, before providing a comprehensive review of the salient molecules, signalling pathways, mechanisms, tumour microenvironmental and therapeutic conditions involved in promoting, selecting and maintaining NB CSC subpopulations, and that underpin their therapy-resistant, self-renewing metastatic behaviour. Finally, we review potential therapeutic strategies and future prospects for targeting and eradication of these bastions of NB therapeutic resistance, post-therapeutic relapse and metastatic progression.

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Neuroblastoma stem cells and CFC1

Cited by 2 publications

References 8 publications

Neuroblastoma Characteristics and Embryonic Origin of The Primary Lesion Site: A SEER Study

Neuroblastoma Characteristics and Embryonic Origin of The Primary Lesion Site: A SEER Study

Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting

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