Neuroblastoma IV‐S Followed by Extra‐Adrenal Pheochromocytoma 15 Years Later

López-Andreu, Juan A.; Castel, Victoria; Verdeguer, Amparo; Muro, Marta; Esquembre, Carlos; Ferrís, J

doi:10.1002/mpo.2950240609

Cited by 5 publications

(5 citation statements)

References 10 publications

(2 reference statements)

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“…A similar patient was reported by Medeiros et al 1999. Similarly, an extra‐adrenal PGL reported by Lopez‐Andrew et al 1995 in a 15‐year‐old girl who survived stage IV‐S NBL diagnosed at 3.5 months of age could be due to mutations in SDHB , rather than, as the authors suggested, the adult tumor developing from residual NBL elements. Evaluation of families with NBL reveals adult members with ganglioneuromas, and later, independent maturation of residual NBL elements to PGL or PCC is probably rare [Shojaei‐Brosseau et al, 2004].…”

Section: Discussionsupporting

confidence: 79%

Thermal properties of epoxidized natural rubber‐based polymer blends

Chan

Sulaiman

Kammer

et al. 2010

J of Applied Polymer Sci

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Thermal properties and morphologies of different thermoplastic polymers blended with an elastomer are discussed. Poly(ethylene terephthalate) (PET), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with 12%mole of hydroxyvalerate content (PHBV) and poly(ethylene oxide) (PEO) were blended with epoxidized natural rubber (ENR). These blends turn out to be immiscible. Degree of crystallinity after isothermal crystallization and equilibrium melting point of the crystallizable constituents stay constant to a good approximation in blends with ENR. Exponential decay of rate of crystallization could be observed for both neat polymers and blends. Morphology formation was observed under condition of constant rate of crystallization, which is concomitantly related to different distances to equilibrium. It turns out that morphology development in the blends reflects both aspects.

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Section: Discussionsupporting

confidence: 79%

Thermal properties of epoxidized natural rubber‐based polymer blends

Chan

Sulaiman

Kammer

et al. 2010

J of Applied Polymer Sci

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“…17 The pheochromocytomatous tumors in our patient, Chromaffin Cell Differentiation of Neuroblastoma however, occurred as disseminated multiple lesions in bilateral lungs during the course of therapy, indicating that these tumors were metastatic but not a secondary malignancy. The reason why this neuroblastoma patient exhibited such an unusual differentiation pattern in her metastatic lesions, leading to a histology similar to that of a pheochromocytoma/paraganglioma, is not clear.…”

Section: Discussionmentioning

confidence: 74%

Unusual Chromaffin Cell Differentiation of a Neuroblastoma After Chemotherapy and Radiotherapy

Miyauchi

Kiyotani²,

Shibata³

et al. 2004

The American Journal of Surgical Pathology

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Neuroblastomas are derived from neural crest cells that are capable of multilineage differentiation. Ganglionic neuronal differentiation of childhood neuroblastoma is seen with increasing age, leading to more differentiated tumors called ganglioneuroblastomas or ganglioneuromas. Despite the fact that neuroblastomas most often arise from the adrenal medulla, chromaffin-cell differentiation in neuroblastomas is not widely recognized. Tumor cells with a chromaffin-cell nature have only been detected using histochemical techniques in neuroblastoma cell lines or focal areas of certain in vivo tumors. We describe a neuroblastoma that exhibited an unusual differentiation toward chromaffin cells in a patient that had been treated with surgery, intensive chemotherapy, and radiotherapy. Although a biopsy specimen of the retroperitoneal primary tumor was extensively necrotic, possibly because of a previous chemotherapy regimen, surgically resected metastatic tumors of bilateral ovaries were viable and diagnosed as poorly differentiated neuroblastomas according to the International Neuroblastoma Pathology Classification system. However, metastatic tumors of bilateral lungs examined at the time of autopsy exhibited histologic features similar to those of a pheochromocytoma/paraganglioma, and immunohistochemical examinations demonstrated that these tumors were composed of extra-adrenal chromaffin cells. This case confirms that neuroblastomas in childhood can transform into pheochromocytoma/paraganglioma-like tumors under special conditions.

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“…To our knowledge, 34 composite PCC-GN cases are reported in literature (6,(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45). Most of these did not involve any genetic An association between a MAX gene mutation and composite PCC with a ganglioneuromatous component has never been described in the literature, while just one composite case has been described involving PGL, in an adolescent who had been successfully treated for a stage IV-S neuroblastoma 15 years earlier (46).…”

Section: Discussionmentioning

confidence: 99%

“…The formation of MAX-MXD1 heterodimers counteracts the dimerization of MYC with MAX, which would act as a transcriptional activator (47). MAX is thus a tumor suppressor gene and its mutation favors the development of hereditary PCCs and PGLs (28,(46)(47)(48).…”

Section: Discussionmentioning

confidence: 99%

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A Novel MAX Gene Mutation Variant in a Patient With Multiple and “Composite” Neuroendocrine–Neuroblastic Tumors

et al. 2020

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Pheochromocytomas (PCCs), paragangliomas (PGLs), ganglioneuroblastomas (GNBs), and ganglioneuromas (GNs) are neuroendocrine neoplasms (NENs) that were thought to share a common embryologic origin from neural crest cells. However, they rarely occur concurrently and recurrently. We describe the case of a 40-years-old woman with "composite PCC-GN" and multiple NENs and neuroblastic tumors. Case presentation: The patient was first referred to our department at the age of 15 years for paroxysmal hypertension, headache, sweating, and watery diarrhea. Her personal history included the diagnosis of a pelvic GNB with lumbar-aortic lymph node metastases at 11 months. Her family history was positive for cerebral glioblastoma multiforme (father). An abdominal ultrasound showed a right adrenal mass that histologically was a "composite adrenal PCC-GN." The symptoms disappeared after surgery. At the age of 20 years, the symptoms returned: computed tomography (CT) and 131I-metaiodobenzylguanidine (MIBG) scintigraphy showed an inter-aortocaval mass, found histologically to be an inter-aortocaval PGL. Her symptoms reappeared again at 28 years: CT and magnetic resonance imaging revealed four left adrenal gland nodules, found histologically to be multifocal PCCs with some atypia. Genetic screening for VHL,

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Neuroblastoma IV‐S Followed by Extra‐Adrenal Pheochromocytoma 15 Years Later

Cited by 5 publications

References 10 publications

Thermal properties of epoxidized natural rubber‐based polymer blends

Thermal properties of epoxidized natural rubber‐based polymer blends

Unusual Chromaffin Cell Differentiation of a Neuroblastoma After Chemotherapy and Radiotherapy

A Novel MAX Gene Mutation Variant in a Patient With Multiple and “Composite” Neuroendocrine–Neuroblastic Tumors

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