Neuroblastoma involvement of the falx cerebri

Quackenbush, Katherine Elizabeth; Luna‐Fineman, Sandra; Magee, James Fergall; Gundogan, Munire; Golobi, Mahin; Irie, Takeshi; Fernandez, Conrad V.

doi:10.1002/pbc.22192

Cited by 10 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The imaging features of IM in NB varied from single brain lesions to diffuse meningeal involvement, with a mean number of four brain lesions (range, 1–10), which is consistent with previous studies ( 10 , 12 , 27 , 29 , 30 ). Most commonly IM lesions are located in the frontal and temporal lobes ( 8 , 31 ).…”

Section: Discussionsupporting

confidence: 89%

Intracranial Metastases Tend to Be Overt and Predict Poor Prognosis in Children With Neuroblastoma

2021

View full text Add to dashboard Cite

Background: Neuroblastoma (NB) is the most common pediatric extracranial solid neoplasm after leukemia. Intracranial metastases (IM) rarely occur in patients with NB. The present study aimed to review the clinical characteristics of NB patients from a single center presenting with IM.Methods: Two hundred children (aged 3–91 months) with NB admitted to the Fourth Affiliated Hospital of China Medical University between January 2009 and December 2015 were enrolled, and their clinical characteristics were recorded. The patients were divided into two groups based on the presence of IM. Their clinical characteristics, including demographics, clinical features, and laboratory and imaging studies, were retrospectively analyzed.Results: IM occurred in 22 of 200 (11%) neuroblastoma patients, with a median age of 42.5 months (range, 3–91 months), with a male-to-female ratio of 1.4:1. Seven patients had IM at the initial diagnosis. Among the 15 children who did not have IM at initial presentation, the median interval from presentation to the diagnosis of IM was 17.3 months (range, 1–55 months). Compared with the control group, NB patients with IM tended to be asymptomatic at the time of NB diagnosis, which was made incidentally during routine physical examination (5 of 22, 22.7%, p < 0.05). In addition, this group had more primary intra-abdominal sites (18 of 22, 81.8%, p < 0.001) and worse prognosis (5 of 22, 22.7%, p < 0.05).Conclusions: NB patients with IM have insidious onset in the early stage and a lower survival rate, especially patients with primary intra-abdominal lesions. Regular neurological monitoring could improve the rate of early diagnosis and prognosis of NB children with IM. Familiarity with the characteristic findings of NB with IM is necessary to avoid misdiagnosis and initiate necessary interventions.

show abstract

Section: Discussionsupporting

confidence: 89%

Intracranial Metastases Tend to Be Overt and Predict Poor Prognosis in Children With Neuroblastoma

2021

View full text Add to dashboard Cite

show abstract

“…Therefore, the possibility that the site of greatest tumor burden was the primary site was considered. A recent report suggests that meninges could be a primary site of neuroblastoma 11. However, in this patient the tumor seems to have originated in the sphenoid bone, since imaging showed the tumor's epicenter was within the sphenoid bone with extensions into intracranial, intraorbital, and extracranial compartments.…”

Section: Discussionmentioning

confidence: 61%

Neuroblastoma of unknown primary site with periorbital bone metastasis in a child

Salmi

Patel

Imashuku

et al. 2010

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…6,9 Conversely, central nervous system metastasis of neuroblastoma has been reported only rarely. 8,10 Intracranial involvement is generally considered to be confined to the dura and leptomeninges, with parenchymal disease usually attributed to direct extension from the adjacent skull or dura, 11,12 as seen in our case. Metastatic spread to the CPA has been reported to arise from primary neoplasms of the lungs, breast, prostate, and melanomas.…”

Section: Discussionmentioning

confidence: 72%

Retroperitoneal Neuroblastoma Metastatic to the Cerebellopontine Angle

Yamakawa¹,

Tamakawa²,

Endo

et al. 2015

Neurosurgery Quarterly

View full text Add to dashboard Cite

Neuroblastoma is the most common extracranial solid tumor in children. Survival rates have improved because of advances in treatment with aggressive chemotherapy and autologous bone marrow transplantation. Usual sites of recurrence and/or metastases include the site of the primary tumor, residual gross disease, bones, bone marrow, liver, and lungs. Central nervous system metastases have been regarded as uncommon; however, it is being increasingly diagnosed due to prolonged overall survival rates. Herein, we describe a 3-year-old boy with stage 4 primary adrenal gland neuroblastoma that metastasized to the pyramidal bone and rapidly extended into the cerebellopontine cistern while he was in the course of therapy for idiopathic thrombocytopenic purpura. He underwent an emergent debulking surgery, and the cerebellopontine angle metastatic lesion almost completely resolved after radical chemotherapy. Although our case is only the fourth case report of the metastatic cerebellopontine angle neuroblastoma in the literature, all clinicians involved in the treatment of pediatric neoplasms need to take this rare disease into consideration as a potential differential diagnosis.Key Words: metastatic neuroblastoma, rapid growth, cerebellopontine angle tumor (Neurosurg Q 2015;25:267-270) C erebellopontine angle (CPA) tumors comprise about 8% to 10% of all intracranial tumors. The majority of these tumors are vestibular schwannoma, followed in predominance by meningioma and epidermoid cyst. Metastases to the CPA are rare, representing only 0.2% to 2.0% of all CPA lesions, and are known to arise from primary neoplasm of the colon, breast, and melanoma. 1-4 Differentiation of these neoplasms from other less common lesions of the CPA is difficult due to the similarity of presenting signs and symptoms. However, distinguishing among lesions is essential for determining prognosis and formulating an appropriate therapeutic protocol. In contrast, neuroblastoma originates from neural crest cells of the adrenal medulla or sympathetic ganglia and is the most common solid extracranial tumor in children, accounting for approximately 7% of all pediatric cancers. 5,6 Over 70% of neuroblastoma patients have progressed to disseminated disease by the time of diagnosis, and these patients have a poor prognosis. 6 Common sites of distant metastases are the bone marrow, bony cortex, liver, lymph nodes, subcutaneous tissue, and intraorbital space. 7,8 Central nervous system metastasis occurs rarely, in only 1% to 16% of cases. Furthermore, metastatic neuroblastoma presenting as a CPA mass is quite rare. Herein, we report a case with intra-abdominal neuroblastoma that unexpectedly spreaded to the CPA. CASE DESCRIPTIONA 3-year-old boy with 1-year therapeutic history for idiopathic thrombocytopenic purpura (ITP) suddenly developed left facial palsy. Before this symptom, he had 4-months history of swaying to the left accompanied by progressive left facial nerve palsy. Headache and somnolence were present for a week before facial palsy developed. Neur...

show abstract

Neuroblastoma involvement of the falx cerebri

Cited by 10 publications

References 16 publications

Intracranial Metastases Tend to Be Overt and Predict Poor Prognosis in Children With Neuroblastoma

Intracranial Metastases Tend to Be Overt and Predict Poor Prognosis in Children With Neuroblastoma

Neuroblastoma of unknown primary site with periorbital bone metastasis in a child

Retroperitoneal Neuroblastoma Metastatic to the Cerebellopontine Angle

Contact Info

Product

Resources

About