Neurobiology of the lateral septum: regulation of social behavior

Menon, Rohit; Süß, Theresa; Oliveira, Vinícius Elias de Moura; Neumann, Inga D.; Bludau, Anna

doi:10.1016/j.tins.2021.10.010

Cited by 70 publications

(53 citation statements)

References 114 publications

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“…How could ILA CRH cells suppress social interactions with a familiar mouse and regulate social novelty preference? ILA CRH projects to rdLS and LS regulates social interactions 19 , which led us to ask whether CRH release from ILA in rdLS is necessary for familiarization. We designed 3 different shRNAs against Crh and had their efficacy tested in cell cultures overexpressing CRH.…”

Section: Resultsmentioning

confidence: 99%

“…Subsequent studies should aim to characterize how social novelty reward facilitate interaction with novel mice to regulate social preference. The lateral septum, which is heavily modulated by dopamine, vasopressin and oxytocin 19 , may act as a hub and also integrate inputs promoting interaction with novel mice in order to regulate social preference.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, rat pups display a preference for their familiar siblings during the first 2 postnatal weeks, after which preference shifts toward novel pups 3,4 . Although the mechanisms that regulate these shifts remains elusive, the lateral septum (LS), a brain region associated with the regulation of motivated behaviors including social interactions 19 , is necessary for kinship/familiarity preference in young rats 3 as well as for social novelty preference in adult rodents [19][20][21] . Moreover, the ventral aspect of medial prefrontal cortex (mPFC), the infra-limbic area (ILA), is known for its involvement in decision-making and recent evidence shows it responds to social stimuli [22][23][24] and is necessary for social novelty preference 25,26 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum supports social novelty preference

León-Reyes

Diaz

Nogueira

et al. 2022

Preprint

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Social preference, the decision to interact with one member of the same species over another, is a key feature of optimizing social interactions. In rodents, social preference relies on both extrinsic factors, such as sex, strain and kinship, and intrinsic ones, such as the memory of previous encounters, which favors interactions with novel compared to familiar animals (social novelty preference). At present, it is unclear which neuronal circuits guide social preferences and whether such circuits promote social interactions with the preferred individuals or suppress interactions with the non- preferred ones. Although both the infra-limbic area of the pre-frontal cortex (ILA) and the lateral septum (LS) have been shown to support social novelty preference, the neuronal circuits and molecular mechanisms by which these brain regions interact to regulate social interactions are unknown. Here, we identify a population of inhibitory neurons in ILA that express the neuropeptide corticotropin releasing hormone (CRH) and project to the rostro-dorsal region of LS (rdLS). Release of CRH from ILA in rdLS during interactions with familiar mice disinhibits rdLS neurons, thereby suppressing interactions with familiar mice and contributing to social novelty preference. We further demonstrate how the maturation of CRH expression during the first two post-natal weeks enables the developmental shift from a preference for littermates in juveniles to a preference for novel mice in adults.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum supports social novelty preference

León-Reyes

Diaz

Nogueira

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…It has been shown that certain populations of neurons in the LS that project to the hypothalamus are important for the promotion of persistent anxiety-like behaviors ( Anthony et al, 2014 ). The LS integrates signals from the external environment and internal state, and in symphony with neurochemicals like OT, works to elicit the appropriate behavioral response ( Menon et al, 2021 ). The direct role of this multifaceted brain region in a social buffering interaction remains to be addressed.…”

Section: Discussionmentioning

confidence: 99%

Behavioral, neurochemical, and neuroimmune changes associated with social buffering and stress contagion

Chun

Donovan

Liu

et al. 2022

Neurobiology of Stress

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Social buffering can provide protective effects on stress responses and their subsequent negative health outcomes. Although social buffering is beneficial for the recipient, it can also have anxiogenic effects on the provider of the social buffering – a phenomena referred to as stress contagion. Social buffering and stress contagion usually occur together, but they have traditionally been studied independently, thus limiting our understanding of this dyadic social interaction. In the present study, we examined the effects of preventative social buffering and stress contagion in socially monogamous prairie voles ( Microtus ochrogaster ). We tested the hypothesis that this dynamic social interaction is associated with coordinated alterations in behaviors, neurochemical activation, and neuroimmune responses. To do so, adult male prairie voles were stressed via an acute immobilization restraint tube (IMO) either alone (Alone) or with their previously pair-bonded female partner (Partner) in the cage for 1 h. In contrast, females were placed in a cage containing either an empty IMO tube (Empty) or one that contained their pair-bonded male (Partner). Anxiety-like behavior was tested on the elevated plus maze (EPM) following the 60-mins test and brain sections were processed for neurochemical/neuroimmune marker labeling for all subjects. Our data indicate that females in the Partner group were in contact with and sniffed the IMO tube more, showed fewer anxiety-like behaviors, and had a higher level of oxytocin expression in the paraventricular nucleus of the hypothalamus (PVN) compared to the Empty group females. Males in the Partner group had lower levels of anxiety-like behavior during the EPM test, greater activation of corticotropin-releasing hormone expressing neurons in the PVN, lower activation of serotonin neurons in the dorsal raphe, and lower levels of microgliosis in the nucleus accumbens. Taken together, these data suggest brain region- and neurochemical-specific alterations as well as neuroinflammatory changes that may be involved in the regulation of social buffering and stress contagion behaviors.

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“…To investigate the potential consequences of the observed rostro-caudal shift in the distribution of the mesencephalic DA neurons, we have also assessed changes in the expression of genes involved in DA neurotransmission in one of the target regions of the mesocorticolimbic pathway, the septum, known to modulate different aspects of social behavior in mice (see for a review Menon et al, 2022 ) as well as in domestic chicks ( Lorenzi et al, 2017 ; Mayer et al, 2017 ). We found that DRD1, DARPP32 and GRIN2A were downregulated upon VPA exposure, suggesting deficits in dopaminergic signaling in this brain region.…”

Section: Discussionmentioning

confidence: 99%

Embryonic Valproate Exposure Alters Mesencephalic Dopaminergic Neurons Distribution and Septal Dopaminergic Gene Expression in Domestic Chicks

Adiletta

Pross

Taricco

et al. 2022

Front. Integr. Neurosci.

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In recent years, the role of the dopaminergic system in the regulation of social behavior is being progressively outlined, and dysfunctions of the dopaminergic system are increasingly associated with neurodevelopmental disorders, including autism spectrum disorder (ASD). To study the role of the dopaminergic (DA) system in an animal model of ASD, we investigated the effects of embryonic exposure to valproic acid (VPA) on the postnatal development of the mesencephalic DA system in the domestic chick. We found that VPA affected the rostro-caudal distribution of DA neurons, without changing the expression levels of several dopaminergic markers in the mesencephalon. We also investigated a potential consequence of this altered DA neuronal distribution in the septum, a social brain area previously associated to social behavior in several vertebrate species, describing alterations in the expression of genes linked to DA neurotransmission. These findings support the emerging hypothesis of a role of DA dysfunction in ASD pathogenesis. Together with previous studies showing impairments of early social orienting behavior, these data also support the use of the domestic chick model to investigate the neurobiological mechanisms potentially involved in early ASD symptoms.

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Neurobiology of the lateral septum: regulation of social behavior

Cited by 70 publications

References 114 publications

Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum supports social novelty preference

Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum supports social novelty preference

Behavioral, neurochemical, and neuroimmune changes associated with social buffering and stress contagion

Embryonic Valproate Exposure Alters Mesencephalic Dopaminergic Neurons Distribution and Septal Dopaminergic Gene Expression in Domestic Chicks

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