Neurobiology of Suicidal Behavior. An Integration of Biological and Clinical Findings

Carballo, Juan J.; Akamnonu, Chibuikem P.; Oquendo, María A.

doi:10.1080/13811110701857004

Cited by 65 publications

(51 citation statements)

References 110 publications

(119 reference statements)

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“…A second study found that gene polymorphisms related to serotonergic functioning (i.e., serotonin transporter gene [5-HTTLPR]) moderate the association between CM and suicidality (Gibb et al 2006). Although in-depth discussion in this area is beyond the scope of this review, excellent reviews on the neurobiological effects of CM (see Cicchetti and Toth 2005; Wilson et al 2011) and suicidal behavior (see Carballo et al 2008; Currier and Mann 2008) are available for interested readers.…”

Section: Conclusion Limitations and Recommendationsmentioning

confidence: 99%

The Relation Between Child Maltreatment and Adolescent Suicidal Behavior: A Systematic Review and Critical Examination of the Literature

Miller

Esposito‐Smythers

Weismoore

et al. 2013

Clin Child Fam Psychol Rev

299

194

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A large body of research suggests that child maltreatment (CM) is associated with adolescent suicidal ideation and attempts. These studies, however, have not been critically examined and summarized in a manner that allows us to draw firm conclusions and make recommendations for future research and clinical work in this area. In this review, we evaluated all of the research literature to date examining the relationship between CM and adolescent suicidal ideation and attempts. Results generally suggest that childhood sexual abuse, physical abuse, emotional abuse, and neglect are associated with adolescent suicidal ideation and attempts across community, clinical, and high-risk samples, using cross-sectional and longitudinal research designs. In most studies, these associations remain significant when controlling for covariates such as youth demographics, mental health, family, and peer-related variables. When different forms of CM are examined in the same multivariate analysis, most research suggests that each form of CM maintains an independent association with adolescent suicidal ideation and suicide attempts. However, a subset of studies yielded evidence to suggest that sexual abuse and emotional abuse may be relatively more important in explaining suicidal behavior than physical abuse or neglect. Research also suggests an additive effect—each form of CM contributes unique variance to adolescent suicide attempts. We discuss the current limitations of this literature and offer recommendations for future research. We conclude with an overview of the clinical implications of this research, including careful, detailed screening of CM history, past suicidal behavior, and current suicidal ideation, as well as the need for integrated treatment approaches that effectively address both CM and adolescent suicidal ideation and suicide attempts.

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Section: Conclusion Limitations and Recommendationsmentioning

confidence: 99%

The Relation Between Child Maltreatment and Adolescent Suicidal Behavior: A Systematic Review and Critical Examination of the Literature

Miller

Esposito‐Smythers

Weismoore

et al. 2013

Clin Child Fam Psychol Rev

299

194

View full text Add to dashboard Cite

show abstract

“…The concept of candidate suicide endophenotypes is also being used to explore the neurobiological basis of suicide [78–81]. Prominent researchers have defined an endophenotype as a “measurable component along the pathway between disease and distal genotype” [82].…”

Section: Endophenotypes and Potential Medication Targetsmentioning

confidence: 99%

Neurobiological aspects of suicide and suicide attempts in bipolar disorder

Mathews

Richards

Niciu

et al. 2013

Translational Neuroscience

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Suicide and bipolar disorder (BD) are challenging, complex, and intertwined areas of study in contemporary psychiatry. Indeed, BD is associated with the highest lifetime risk for suicide attempt and completion of all the psychiatric conditions. Given that several clinical risk factors for both suicide and BD have been well noted in the literature, exploring the neurobiological aspects of suicide in BD may provide insights into both preventive measures and future novel treatments. This review synthesizes findings regarding the neurobiological aspects of suicide and, when applicable, their link to BD. Neurochemical findings, genes/epigenetics, and potential molecular targets for current or future treatments are discussed. The role of endophenotypes and related proximal and distal risk factors underlying suicidal behavior are also explored. Lastly, we discuss the manner in which preclinical work on aggression and impulsivity may provide additional insights for the future development of novel treatments.

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“…Several risk factors that increase risk for suicidal behavior include depressed mood (Arsenault-Lapierre et al, 2004; Mann et al, 1999; Schwartz-Lifshitz et al, 2012; Yoshimasu et al, 2008); personality disorders with impulsive behavioral traits (Chesin et al, 2010; Goodman et al, 2012; Mann et al; 2008); family history of suicidal behavior (Diaconu & Turecki, 2009; Mann et al, 2008; Nock et al, 2008); adverse childhood experiences (Borges et al, 2010; Brodsky & Stanley, 2008; Bruffaerts et al, 2010; Lopez-Castroman et al, 2013; Mann et al, 2008); and a prior history of suicide attempts (Jenkins et al, 2002; Ruengorn et al, 2011; Suominen et al, 2004). However, suicide attempts are heterogeneous in terms of intent, degree of planning and resultant medical injury (Carballo et al, 2008) and it is likely that the risk factors will vary according to these dimensions.…”

Section: Introductionmentioning

confidence: 99%

Clinical Correlates of Planned and Unplanned Suicide Attempts

et al. 2016

Self Cite

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Suicide attempters differ in the degree of planning for their suicide attempts. The purpose of this study is to identify differences between individuals who make planned (≥3 hours of planning) and unplanned (<3 hours of planning) suicide attempts. Depressed suicide attempters (n=110) were compared based on degree of planning of their most recent suicide attempt on demographic and clinical variables. Participants who made planned suicide attempts were more likely to have: family history of completed suicide; more severe and frequent suicidal ideation; greater trait impulsivity; and greater suicidal intent and more severe medical consequences for both their most recent and most serious suicide attempts. These results suggest clear clinical differences based on the degree of suicide attempt planning. Severe suicidal ideation, high suicide intent, family history of suicide completion, and high levels of motor impulsivity contribute to a phenotype that is at greater risk for planned, highly lethal suicide attempts.

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Neurobiology of Suicidal Behavior. An Integration of Biological and Clinical Findings

Cited by 65 publications

References 110 publications

The Relation Between Child Maltreatment and Adolescent Suicidal Behavior: A Systematic Review and Critical Examination of the Literature

The Relation Between Child Maltreatment and Adolescent Suicidal Behavior: A Systematic Review and Critical Examination of the Literature

Neurobiological aspects of suicide and suicide attempts in bipolar disorder

Clinical Correlates of Planned and Unplanned Suicide Attempts

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