Neurobiology of Muscle Fatigue

Sc, Gandevia; Rm, Enoka; Aj, McComas; Dg, Stuart; Ck, Thomas

doi:10.1007/978-1-4899-1016-5_39

Cited by 77 publications

(52 citation statements)

References 18 publications

(9 reference statements)

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Section: Causes Of Fatiguementioning

confidence: 99%

“…Three broad schools of thought identify mechanisms pertaining to the origins of physical fatigue: (1) peripheral mechanisms (Allen, Lamb, & Westerblad, 2008;Asmussen, 1979;Edwards, 1981;Fitts, 1994;Westerblad, Allen, & Lannergren, 2002;Westerblad, Lee, Lannergren, & Allen, 1991), (2) central mechanisms (Gandevia, 2001;Gandevia, Enoka, McComas, Stuart, & Thomas, 1995;Weir, Beck, Cramer, & Housh, 2006), and (3) and peripheral plus central mechanisms. Different treatment strategies include diet/metabolite replenishment, cardiovascular training and efficiency training.…”

Section: Prefacementioning

confidence: 99%

“…Additionally, decreased recruitment of many muscle groups simultaneously prevents the progression of peripheral fatigue (Gandevia, 1995). An important point is that a relationship has been identified between metabolite accumulation in the periphery and inhibitory feedback and oxygen supply to the brain to maintain homeostasis, thereby connecting peripheral and central mechanisms in fatigue (Amann & Dempsey, 2008).…”

Section: Causes Of Fatiguementioning

confidence: 99%

“…In this approach, fatigue is seen as a reduction in neural drive to the muscle, resulting in a decline in force production, independent of changes in the contractile machinery (Amann & Calbet, 2008;Enoka & Stuart, 1992). Central fatigue is attributed to the reduction in neural drive to motor neurons and an inhibition of motoneuron excitability -where a motor neuron is defined as a single motor neuron and all the muscle fibers it innervatessubsequent to afferent feedback from the muscle (Davis & Bailey, 1997;Gandevia, et al, 1995).A speculation is that such inhibition is the body's attempt to maintain system homeostasis and 27 prevent organ (i.e., muscle damage or heart) failure Noakes, St Clair Gibson, & Lambert, 2004, 2005. Additionally, decreased recruitment of many muscle groups simultaneously prevents the progression of peripheral fatigue (Gandevia, 1995).…”

mentioning

confidence: 99%

“…Central fatigue is attributed to the reduction in neural drive to motor neurons and an inhibition of motoneuron excitability -where a motor neuron is defined as a single motor neuron and all the muscle fibers it innervatessubsequent to afferent feedback from the muscle (Davis & Bailey, 1997;Gandevia, et al, 1995).…”

mentioning

confidence: 99%

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Metabolic Mechanisms of Vocal Fatigue

2017

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Vocal fatigue is among the most debilitating conditions affecting individuals with voice disorders. Impressions about mechanisms potentially underlying vocal fatigue have varied depending on how fatigue is defined, participants studied, and measures made, thereby impacting the selection of treatment strategies that may alleviate the condition. However, little is currently known about actual metabolic mechanisms of vocal fatigue. The current study aimed to address this issue by investigating the hypothesis that neuromuscular inefficiency, cardiovascular recovery deficits, or both, may play a role in fatigue. The approach replicated well-vetted approaches in exercise physiology.Metabolic profiles of subjects with vocal fatigue were assessed using gas exchange measures in comparison to two non-fatigue groups: vocally healthy and cardiovascular trained individuals, recruited based on results from a newly vetted questionnaire, the Vocal Fatigue Index (VFI) and laryngeal examination. Participants read out loud at two different loudness levels for a duration of 5 minutes for each task with periods of rest between tasks. Metabolic cost for and recovery time from reading were same across all groups. Oxygen uptake and recovery kinetics (EPOC), ratings of perceived exertion revealed interesting patterns in individuals with vocal fatigue compared to cardiovascular trained individuals in particular.Specifically, slow oxygen uptake kinetics in the vocal fatigue compared to the cardiovascular iv trained group pointed to utilization of anaerobic energy source to meet the demands of the reading task in the vocal fatigue group, suggesting neuromuscular inefficiency. In contrast, rapid oxygen uptake kinetics in the cardiovascular trained group pointed to utilization of aerobic energy sources and greater neuromuscular efficiency. Similarly, a greater number of individuals in vocal fatigue and vocally healthy groups showed an increase in oxygen consumption post reading (EPOC) compared to the cardiovascular trained group, indicating possible cardiovascular recovery deficits in the former groups.In addition to uncovering potential mechanisms underlying vocal fatigue, including neuromuscular inefficiency and cardiovascular recovery deficits, results from the present study highlight the potential importance of aerobic training to generate aerobic energy required for vocal task demands for both ease of task performance and recovery from it. In sharp contrast to the situation for voice, fatigue as a common physical phenomenon more generally has received extensive attention in the physical therapy, sports medicine, and exercise physiology literature. Three broad schools of thought identify mechanisms pertaining to the origins of physical fatigue: (1) peripheral mechanisms (Allen, Lamb, & Westerblad, 2008;Asmussen, 1979;Edwards, 1981;Fitts, 1994;Westerblad, Allen, & Lannergren, 2002;Westerblad, Lee, Lannergren, & Allen, 1991), (2) The next pages and chapters provide pertinent background information on vocal fatigue, fatigue as understood ...

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Section: Causes Of Fatiguementioning

confidence: 99%

Section: Prefacementioning

confidence: 99%

Section: Causes Of Fatiguementioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Metabolic Mechanisms of Vocal Fatigue

2017

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Contractile Performance of Skeletal Muscle Fibres

Edman¹

2003

Strength and Power in Sport

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Structural and physical properties of silk fibroin/alginate blend sponges

Lee

Kweon

Yeo

et al. 2004

J of Applied Polymer Sci

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Silk fibroin/alginate blend sponges were examined through IR spectroscopy, X-ray diffractometry, and differential scanning calorimetry to determine the structural changes of silk fibroin. The effects of fibroin/alginate blend ratios on the physical and mechanical properties were investigated to discover the feasibility of using these blend sponges as biomedical materials such as wound dressings. The compressive modulus of silk fibroin was increased up to 30 kPa, from 7.1 kPa, by blending with alginate. Thermal crystallization behavior of fibroin induced by heat treatment was restricted by blending with alginate. In spite of that, the structural characteristics of fibroin were not changed by incorporation with alginate.

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Neurobiology of Muscle Fatigue

Cited by 77 publications

References 18 publications

Metabolic Mechanisms of Vocal Fatigue

Metabolic Mechanisms of Vocal Fatigue

Contractile Performance of Skeletal Muscle Fibres

Structural and physical properties of silk fibroin/alginate blend sponges

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