Neurobiology of Insomnia

Bastien, Célyne; Provencher, Thierry; Lebel, Jessica; Bolduc-Landry, R.

doi:10.1007/978-3-030-54359-4_7

Cited by 1 publication

(1 citation statement)

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“…Consequently, attentional activity will focus on looking for potentially harmful stimuli, increasing brain activity, and feeding back concerns and worry about falling asleep. This fact of paying attention to internal and external stimuli and sensations has been contrasted using neuroimaging and neuronal activity recording techniques, supporting the central hypothesis of brain hyperactivation that underlies this model ( Bastien et al, 2021 ).…”

Section: Introductionmentioning

confidence: 71%

Study Protocol for a Randomized Controlled Trial Assessing the Effectiveness of Personalized Computerized Cognitive Training for Individuals With Insomnia

Tapia

Puertas

Duñabeitia

2022

Front. Behav. Neurosci.

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Insomnia is a frequent and heightened pathology in the general population of developed countries, and its condition generally leads to health discomfort and performance drop in daily and work-related tasks. As current pharmacological treatments for insomnia do not always seem sufficient to mitigate impairment, contemporary cognitive approaches might shed light on developing complementary therapies for this population. We propose a cognitive stimulation intervention program based on the importance of cognitive abilities as precipitating and maintenance variables of sleep disturbances. A full phase I-II-III clinical trial is proposed in which the first two studies will serve to assess the safety of the intervention and to identify the maximum tolerated time of the computerized cognitive training (phase I) and the minimum effective number of training sessions (phase II) in the absence of adverse events or side effects. Next, a phase-III double-blind randomized controlled trial design will be set. Sixty individuals with insomnia aged 25 to 55 years will enroll in a home-based personalized computerized cognitive stimulation program for a total time of 8 weeks, training 5 days per week. Sixty insomnia patients matched in a variety of factors will constitute the active control group, where the orthogonal activities will not be cognitively demanding. Sleep, cognitive, emotional, and quality of life variables will be measured before and immediately after training. A linear mixed model and hierarchical regression analysis will be used to investigate intervention effects. The results derived from this study will be precious for future research and treatment in cognitive performance and clinical pathologies.Clinical Trial Registration: [https://clinicaltrials.gov/], identifier [NCT05050292].

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Section: Introductionmentioning

confidence: 71%