Neurobiology of Fear Memory ☆

Rajbhandari, Abha K.; Tribble, Jennifer Elizabeth; Fanselow, Michael S.

doi:10.1016/b978-0-12-809324-5.21100-0

Cited by 2 publications

(3 citation statements)

References 228 publications

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“…More specifically, shorter weekday sleep duration was significantly associated with smaller BLA but not CMA volume. The BLA has been shown to be susceptible to early life stress (Oshri et al., 2019 ) and is associated with the regulatory response to emotionally salient environmental stimuli (Rajbhandari et al., 2017 ; Skelly et al., 2020 ). Sleep‐duration‐related differences in BLA volume may partially underlie the effects of sleep sufficiency on emotion processing and regulation, including fear conditioning and extinction (Simon et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, in another study, sleep duration was not found to be significantly associated with amygdala volume in 9‐ to 11‐year‐olds (Cheng et al., 2020). The amygdala includes the basolateral (BLA) and centromedial amygdala (CMA) subregions, which have distinct cellular architecture and connectivity patterns (Mosher et al., 2010 ; Rajbhandari et al., 2017 ; Skelly et al., 2020 ). Previous literature has suggested effects of early life stress on both the BLA and CMA (McEwen, 2007 ; Oshri et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Socioeconomic disparities in sleep duration are associated with cortical thickness in children

et al. 2022

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Introduction Disrupted sleep has been consistently linked with lower academic achievement and worse mental health in children. Less is understood about sleep as a potential factor underlying socioeconomic differences in brain morphometry in children. The goals of this study were to investigate the associations among socioeconomic factors, sleep duration, and brain morphometry in children, and to examine the roles of the sleep environment and family routines in these associations. Methods Participants were 5‐ to 9‐year‐old children from socioeconomically diverse families (N = 94; 61% female). Parents reported on children's weekday and weekend sleep durations, sleep environment, and family routines. High‐resolution, T1‐weighted structural magnetic resonance imaging (MRI) data were acquired. Analyses focused on cortical thickness, cortical surface area, and amygdala and hippocampal volume. Results Results indicated that lower family income‐to‐needs ratio and parental education were significantly associated with shorter weekday sleep duration in children. Shorter weekday sleep duration was significantly associated with reduced thickness in the left middle temporal, right postcentral, and right superior frontal cortices and smaller basolateral but not centromedial amygdala volume. Family routines significantly mediated the associations of family income‐to‐needs ratio and parental education with weekday sleep duration in children. Conclusion These results contribute to our understanding of sleep factors as proximal mechanisms through which socioeconomic context may alter neural development during childhood.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Socioeconomic disparities in sleep duration are associated with cortical thickness in children

et al. 2022

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“…For decades, aversive Pavlovian conditioning has been an effective model for human fear and anxiety (Lissek et al, 2005 ). Using this procedure great advancements in the understanding of the neurobiology that regulate behavior in aversive motivation have been made (Rajbhandari et al, 2017 ). Additionally, potential clinical applications to treat patients that suffer from maladaptive fear and anxiety, such as extinction have been explored using this framework (Morgan and LeDoux, 1995 ; Quirk et al, 2000 ; Maren and Holmes, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Conditional Control of Instrumental Avoidance by Context Following Extinction

Campese

Brannigan

LeDoux

2021

Front. Behav. Neurosci.

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Using rodents, three training arrangements (i.e., ABB vs. ABA, AAA vs. AAB and ABB vs. ABC) explored whether extinction influences the expression of avoidance in a manner controlled by context. Retention testing following extinction showed that more avoidance responding (i.e., renewal) was observed when extinguished cues were tested outside of the context where they had undergone extinction. In contrast, response rates were significantly lower when stimuli were tested within the context where extinction learning had occurred. These findings add to the emerging literature assessing the role of Pavlovian extinction processes in the development of instrumental avoidance responding by demonstrating conditional control over extinguished responding by context. This study was conducted using a within-subjects approach that minimized the potential for context-outcome associations to bias responding, and thus, reflects hierarchical control over behavior based on the specific associative status of each tested cue in each training context.

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Neurobiology of Fear Memory ☆

Cited by 2 publications

References 228 publications

Socioeconomic disparities in sleep duration are associated with cortical thickness in children

Socioeconomic disparities in sleep duration are associated with cortical thickness in children

Conditional Control of Instrumental Avoidance by Context Following Extinction

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