Neurobiology of Aggressive Behavior—Role of Autoantibodies Reactive With Stress-Related Peptide Hormones

Værøy, Henning; Schneider, Frida; Fetissov, Sergueı̈ O.

doi:10.3389/fpsyt.2019.00872

Cited by 11 publications

(7 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We did not observe an effect of aMSH treatment on R. imitator tadpoles, which reinforces findings in O. pumilio tadpoles that aggression and hunger are decoupled [44]. Aggression studies with ACTH also suggest a role for promoting aggression, where mice injected with ACTH attack intruders more quickly [80], and rats bred for low anxiety had higher plasma corticotropin (ACTH) and subsequently exhibited higher levels of aggression as compared to high anxiety-bred or control rats [81]. Interestingly, injecting mice daily with ACTH will initially lead to an increase in aggression, but causes a decrease in aggressive action by days 4-7 [82].…”

Section: Discussionsupporting

confidence: 84%

Section: Neuromodulators Of Aggression Vary Across Development and Sp...supporting

confidence: 85%

See 1 more Smart Citation

Proopiomelanocortin (POMC) is a negative regulator of tadpole aggression through opioid receptor signaling

McKinney

Ludington

Butler

et al. 2022

Preprint

View full text Add to dashboard Cite

Aggression is a common behavioral response to limited environmental resources. Most research on the neural basis of aggression in vertebrates focuses on adult males, where sex steroid hormones and the ventromedial hypothalamus are important regulators of aggressive behavior. However, the young of many species also display aggression, although the neural basis of juvenile aggression is not well understood. Here we examine juvenile aggression in Mimic poison frog (Ranitomeya imitator) tadpoles, who live in small isolated pools with limited resources and display aggressive behaviors towards intruder tadpoles. We first conducted a longitudinal study of dyadic behavior and found aggressive behavior increases with tadpole age. We next evaluated which brain regions may be important for tadpole aggression by quantifying pS6-positive cells as a proxy for neural activity. We found more pS6-positive cells in the ventral hypothalamus of aggressive tadpoles compared to controls, similar to findings in adult mammals. We then quantified colocalization of pS6 with vasopressin and oxytocin cells and found no difference across behavior groups. Based on this information, we hypothesized that similar brain regions, but different neuromodulators, may promote aggression in juvenile tadpoles compared to the literature in adult animals. We then used an untargeted approach to molecularly profile pS6-positive neurons and found enrichment of the proopiomelanocortin (POMC) gene in aggressive tadpoles. As POMC is cleaved into several signaling peptides, we used pharmacology to target each pathway and discovered that blocking opioid receptors increases aggressive behavior. Together, this work suggests that POMC-derived B-endorphin is a negative regulator of juvenile aggression through the opioid receptor signaling. More broadly, this work suggests that similar brain regions, but different signaling molecules may be used to regulate aggression in adult and juvenile animals.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Neuromodulators Of Aggression Vary Across Development and Sp...supporting

confidence: 85%

Proopiomelanocortin (POMC) is a negative regulator of tadpole aggression through opioid receptor signaling

McKinney

Ludington

Butler

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Unlike CSF neuropeptide levels, plasma neuropeptide levels do not reflect directly central nervous system neuropeptides concentrations; hence, the absence of association in this study may have been unavoidable. Considering previous preclinical 5,9,10 and clinical 4,6–8 reviews, regional structural or functional brain alterations related to neuropeptides could occur in patients with psychiatric disorders although our data suggested that such alterations may not be reflected in plasma neuropeptide levels. Molecular imaging (e.g., positron emission and single photon emission computed tomography) studies targeting neuropeptides in the brain may explain the pathomechanism of neuropeptides in patients with psychiatric disorders, although such studies are still scarce in preclinical 60,61 and clinical stages 62–64 …”

Section: Discussionmentioning

confidence: 56%

Plasma neuropeptide levels in patients with schizophrenia, bipolar disorder, or major depressive disorder and healthy controls: A multiplex immunoassay study

Hidese

Yoshida

Ishida

et al. 2022

Neuropsychopharm Rep

View full text Add to dashboard Cite

show abstract

“…However, a recent meta-analysis showed only marginal support for the dual-hormone hypothesis for risk taking, aggression, dominance, and psychopathy (Dekkers et al, 2019 ). Other physiological factors have also been investigated as potential moderators (e.g., neuropeptides; Vaeroy et al, 2019 ). Psychological factors may also play a role in the relation between cortisol and aggression.…”

Section: Introductionmentioning

confidence: 99%

Adrenocortical Activity and Aggressive Behavior in Children: A Longitudinal Study on Risk and Protective Effects

Bender

Lösel

2021

Front. Psychol.

View full text Add to dashboard Cite

Most research on aggression and delinquency concentrates on risk factors. There has been less attention for protective factors and mechanisms, in particular with regard to biosocial influences. Based on theories of autonomous arousal and stress reactance the present study addresses the influence of adrenocortical activity as a risk and/or protective factor in the development of antisocial behavior in children. We also investigated relations to anxiousness and family stressors. In a prospective longitudinal study of 150 German boys, the first measurement took place at preschool age and contained an assessment of cortisol after waking up and 30 min later. Aggressiveness and anxiousness of the children were assessed by the kindergarten teachers with the Social Behavior Questionnaire. After 6 years, the children's behavior was rated by the teachers in middle school. Variable-oriented data analyses revealed a significant correlation between the total amount of cortisol after waking up and 30 min later (AUCG) and anxiousness both cross-sectionally and longitudinally, but not with aggressiveness. A family stress index correlated positively with aggressiveness but neither with cortisol nor with anxiousness. There were significant correlations between aggressiveness and anxiousness at kindergarten age and the respective behavior problems 6 years later. In a linear regression analysis on aggression only family stress had a significant effect but anxiousness not. Moderator analyses on aggressiveness with anxiousness and AUCG or on AUCG with anxiousness and aggressiveness did not show any significant interactions. Longitudinally, only aggression significantly predicted aggression 6 years later in a linear regression. In addition to variable-oriented analyses, we also applied a person-oriented approach to investigate specific patterns of behavior. Children who were high in both aggressiveness and anxiousness had the highest cortisol level and those with low anxiousness and high aggressiveness the lowest. The groups with different patterns of externalizing and internalizing problems at preschool age showed significant differences in aggression 6 years later. Our results underline the need for complex pattern analyses on cortisol, aggression, and anxiousness in children and for a differentiated consideration of emotional reactive aggression and unemotional instrumental aggression.

show abstract

Neurobiology of Aggressive Behavior—Role of Autoantibodies Reactive With Stress-Related Peptide Hormones

Cited by 11 publications

References 93 publications

Proopiomelanocortin (POMC) is a negative regulator of tadpole aggression through opioid receptor signaling

Proopiomelanocortin (POMC) is a negative regulator of tadpole aggression through opioid receptor signaling

Plasma neuropeptide levels in patients with schizophrenia, bipolar disorder, or major depressive disorder and healthy controls: A multiplex immunoassay study

Adrenocortical Activity and Aggressive Behavior in Children: A Longitudinal Study on Risk and Protective Effects

Contact Info

Product

Resources

About