Neurobiology and phenotypic expression in early onset schizophrenia

Vyas, Nora S.; Patel, Neva; Puri, Basant K.

doi:10.1111/j.1751-7893.2010.00253.x

Cited by 63 publications

(44 citation statements)

References 155 publications

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“…Cognition in schizophrenia is impaired across multiple domains, including memory, attention, processing speed, and executive function (Keefe and Harvey, 2012;Vyas et al, 2011). Cognitive impairment in schizophrenia is directly related to socio-vocational function, which can have a greater adverse effect on brain function than the positive or negative symptoms of schizophrenia (Velligan et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Cognitive differences in schizophrenia on long-term treatments with clozapine, risperidone and typical antipsychotics

Han

Zhang

Chen

et al. 2015

International Clinical Psychopharmacology

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Cognitive differences in schizophrenia on long-term treatments with clozapine, risperidone and typical antipsychotics AbstractCognitive deficits are a core feature of schizophrenia. There is ongoing debate on whether cognition is affected by antipsychotic drugs (APDs). This study examined the effect of long-term treatment with APDs on cognition in schizophrenia. Cognitive function was assessed in 418 patients with schizophrenia on long-term treatment with APDs (215 on clozapine, 91 on risperidone and 112 on typical APDs) and 159 healthy controls using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Schizophrenia symptomatology was assessed using the Positive and Negative Syndrome Scale (PANSS). We found that cognitive test scores were significantly lower in all patients compared with the healthy controls on almost all of the total and subscores of RBANS (all P<0.001), except for the visuospatial/constructional index. Individuals taking clozapine showed worse immediate and delayed memory performance than those taking typical APDs (all P<0.01). Moreover, individuals taking clozapine showed better language performance than those taking risperidone (P<0.01). Immediate memory and delayed memory were modestly correlated with the types of APDs and the PANSS negative scores. Our results show that individuals taking clozapine performed worse in immediate and delayed memory than those taking typical APDs, but exemplified better language performance than those taking risperidone. show that individuals taking clozapine performed worse in immediate and delayed memory than those taking typical APDs, but exemplified better language performance than those taking risperidone. Disciplines Medicine and Health Sciences

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Section: Introductionmentioning

confidence: 99%

Cognitive differences in schizophrenia on long-term treatments with clozapine, risperidone and typical antipsychotics

Han

Zhang

Chen

et al. 2015

International Clinical Psychopharmacology

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“…When the disorder begins in early adolescence (under 18 years old) it is termed early onset schizophrenia (EOS), with some cases beginning even earlier (under 14 years old) and called child onset schizophrenia (COS) or very early onset schizophrenia (VEOS) [1][2][3] . EOS is a rare condition and it is estimated to account for less than 4% of the cases of schizophrenia 4 .…”

Section: Introductionmentioning

confidence: 99%

“…EOS is a rare condition and it is estimated to account for less than 4% of the cases of schizophrenia 4 . Delusions, hallucinations and thought disorders are considered prominent psychopathological features of EOS 1,4 similar to adult onset schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

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Thought and language disorders in very early onset schizophrenia, schizoaffective disorder and bipolar disorder

Pantano¹,

Fu²,

Curatolo³

et al. 2016

Arch. Clin. Psychiatry (São Paulo)

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Background: Thought and language disorders are main features of adults with schizophrenia and bipolar disorders however studies on such abnormalities are scant in young patients with very early onset psychosis (VEOS). The aim of the present study is to assess the relationship between language and thought disorders in patients with very early onset schizophrenia (SCZ), schizoaffective disorders (SCA) and bipolar disorders (BD). Method: Forty-one patients (18 SCZ, 16 BD, and 7 SCA) with mean age less than 15 years old were assessed through a series of neurocognitive and psycholinguistic tests, including the Thought, Language and Communication Scale (TLC). Results: SCZ group performed worse in all tests as well as the TLC, followed by SCA and BD groups respectively. Thought disorders were related to deficits in executive functioning and semantic processing, and the metaphors' test was the best predictor of TLC functioning. Discussion: TD in SCZ, SCA and BD are one of the most important features in patients with VEOS and that the evaluation of metaphor comprehension can be an important instrument in the early detection of this disorder.

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“…Furthermore, patients with EOS demonstrate significant cognitive impairments in specific domains, mainly general intellectual ability [36][37][38][39][40][41][42], memory [43][44][45][46][47], attention [43,48,49], and executive function [46,48,50,51]. Studying early-onset cases may provide important insights into the etiopathogenesis of the disorder [50][51].…”

Section: Children and Adolescents With Schizophreniamentioning

confidence: 99%

Theory of Mind in the Early Course of Schizophrenia

Vyas

et al. 2017

CPSR

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Theory of mind deficit is a core feature of schizophrenia and is considered a vulnerability marker of the disorder. The majority of studies measuring theory of mind in schizophrenia involve multiple-episode or chronic schizophrenia patients, and therefore it is important to delineate whether these deficits occur before or following illness-onset by assessing high-risk subjects (clinical high risk and ultra-high risk), early-onset psychosis, and first-degree relatives. We address the question of whether theory of mind impairment is specific or a facet of general cognitive impairment in these clinical populations, and incorporate genetic and neuroimaging studies on theory of mind. The review provides a succinct evaluation of the literature, discusses current limitations and proposes future directions.

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Neurobiology and phenotypic expression in early onset schizophrenia

Cited by 63 publications

References 155 publications

Cognitive differences in schizophrenia on long-term treatments with clozapine, risperidone and typical antipsychotics

Cognitive differences in schizophrenia on long-term treatments with clozapine, risperidone and typical antipsychotics

Thought and language disorders in very early onset schizophrenia, schizoaffective disorder and bipolar disorder

Theory of Mind in the Early Course of Schizophrenia

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