Neurobiological predictors for clinical trajectories in fully remitted depressed patients

Blank, Thomas S.; Meyer, Bernhard M.; Rabl, Ulrich; Schögl, Paul; Wieser, Marie-Kathrin; Pezawas, Lukas

doi:10.1002/da.23108

Cited by 7 publications

(3 citation statements)

References 46 publications

(71 reference statements)

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“…However, the results of the NAc volume changes in MDD patients are inconsistent. Compared with the HC group, while some studies found MDD patients have smaller GMV of the NAc [47,52], others suggested MDD patients have larger GMV [53,54] or unchanged GMV [55]. We speculate that this inconsistency may be due to the high heterogeneity of MDD because not all MDD patients experience significant anhedonia symptoms.…”

Section: Discussionmentioning

confidence: 87%

Atrophy of bilateral nucleus accumbens in melancholic depression

Chu

Yuan

et al. 2023

NeuroReport

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Evidence from previous literature suggests that the nucleus accumbens (NAc), hippocampus, and amygdala play critical roles in the reward circuit. Meanwhile, it was also suggested that abnormalities in the reward circuit might be closely associated with the symptom of anhedonia of depression. However, few studies have investigated the structural alterations of the NAc, hippocampus, and amygdala in depression with anhedonia as the main clinical manifestation. Thus, the current study aimed to explore the structural changes of the subcortical regions among melancholic depression (MD) patients, especially in the NAc, hippocampus, and amygdala, to provide a theoretical basis for understanding the pathological mechanisms of MD. Seventy-two MD patients, 74 nonmelancholic depression (NMD) patients, and 81 healthy controls (HCs) matched for sex, age, and years of education were included in the study. All participants underwent T1-weighted MRI scans. Subcortical structure segmentation was performed using the FreeSurfer software. MD and NMD patients had reduced left hippocampal volume compared with HCs. Meanwhile, only MD patients had reduced bilateral NAc volumes. Moreover, correlation analyses showed correlations between left NAc volume and late insomnia and lassitude in MD patients. The reduced hippocampal volume may be related to the pathogenesis of major depressive disorder (MDD), and the reduced volume of the NAc may be the unique neural mechanism of MD. The findings of the current study suggest that future studies should investigate the different pathogenic mechanisms of different subtypes of MDD further to contribute to the development of individualized diagnostic and treatment protocols.

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Section: Discussionmentioning

confidence: 87%

Atrophy of bilateral nucleus accumbens in melancholic depression

Chu

Yuan

et al. 2023

NeuroReport

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“…The majority of research conducted in MDD has largely focused on discerning differences between patients and healthy controls or predicting vulnerability for relapse from baseline assessments. In this respect, dominance of activity within the DMN has been associated with MDD recurrence and related to rumination (Lythe et al, 2015 ; Marchetti et al, 2012 ), whilst decreased within network FC of the DMN has been shown to predict more depressive symptoms within a 2‐year follow‐up period (Blank et al, 2021 ). Another study points to the neuro‐progressive nature of MDD, with remitted depressed patients (compared to first episode patients) showing hyper‐connectivity in a wide range of networks, including the DMN (Liu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Depression recurrence is accompanied by longer periods in default mode and more frequent attentional and reward processing dynamic brain‐states during resting‐state activity

Alonso,

Tyborowska,

Ikani

et al. 2023

Human Brain Mapping

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Recurrence in major depressive disorder (MDD) is common, but neurobiological models capturing vulnerability for recurrences are scarce. Disturbances in multiple resting‐state networks have been linked to MDD, but most approaches focus on stable (vs. dynamic) network characteristics. We investigated how the brain's dynamical repertoire changes after patients transition from remission to recurrence of a new depressive episode. Sixty two drug‐free, MDD‐patients with ≥2 episodes underwent a baseline resting‐state fMRI scan when in remission. Over 30‐months follow‐up, 11 patients with a recurrence and 17 matched‐remitted MDD‐patients without a recurrence underwent a second fMRI scan. Recurrent patterns of functional connectivity were characterized by applying Leading Eigenvector Dynamics Analysis (LEiDA). Differences between baseline and follow‐up were identified for the 11 non‐remitted patients, while data from the 17 matched‐remitted patients was used as a validation dataset. After the transition into a depressive state, basal ganglia‐anterior cingulate cortex (ACC) and visuo‐attentional networks were detected significantly more often, whereas default mode network activity was found to have a longer duration. Additionally, the fMRI signal in the basal ganglia‐ACC areas underlying the reward network, were significantly less synchronized with the rest of the brain after recurrence (compared to a state of remission). No significant changes were observed in the matched‐remitted patients who were scanned twice while in remission. These findings characterize changes that may be associated with the transition from remission to recurrence and provide initial evidence of altered dynamical exploration of the brain's repertoire of functional networks when a recurrent depressive episode occurs.

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“…The majority of research conducted in MDD has largely focused on discerning differences between patients and healthy controls or predicting vulnerability for relapse from baseline assessments. In this respect, dominance of activity within the DMN has been associated with MDD recurrence and related to rumination (Lythe et al, 2015; Marchetti, Koster, Sonuga-Barke, and De Raedt, 2012), whilst decreased within network FC of the DMN has been shown to predict more depressive symptoms within a 2 year follow-up period (Blank et al, 2021). Another study points to the neuro-progressive nature of MDD, with remitted depressed patients (compared to first episode patients) showing hyper-connectivity in a wide range of networks, including the DMN (Liu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Segregation of dynamic resting-state reward, default mode and attentional networks after remitted patients transition into a recurrent depressive episode

Alonso

Tyborowska

Ikani

et al. 2022

Preprint

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Introduction: Recurrence in major depression disorder (MDD) is common, but neurobiological models capturing vulnerability for recurrences are scarce. Disturbances in multiple resting-state networks have been linked to MDD, but most approaches focus on stable (vs. dynamic) network characteristics. We investigated how the brain's dynamical repertoire changes after patients transition from remission to recurrence of a new depressive episode. Methods: Sixty drug-free, MDD-patients with more than 2 episodes underwent a baseline resting-state fMRI scan when in remission. Over 30-months follow-up, 11 patients with a recurrence and 17 matched-remitted MDD-patients without a recurrence underwent a second fMRI scan. Recurrent patterns of functional connectivity were characterized by applying leading eigenvector dynamics analysis (LEiDA). Differences between baseline and follow-up were identified for the 11 non-remitted patients, while data from the 17 matched-remitted patients was used as a validation dataset. Results: After the transition into a depressive state, the reward and a visuo-attentional networks were detected significantly more often, whereas default mode network activity was found to have a longer duration. Additionally, the fMRI signal in the areas underlying the reward network were significantly less synchronized with the rest of the brain after recurrence (compared to a state of remission). These changes were not observed in the matched-remitted patients who were scanned twice while in remission. Conclusion: These findings characterize the changes that are specifically associated with the transition from remission to recurrence and provide first evidence of increased segregation in the brain's dynamical repertoire when a recurrent depressive episode occurs.

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Neurobiological predictors for clinical trajectories in fully remitted depressed patients

Cited by 7 publications

References 46 publications

Atrophy of bilateral nucleus accumbens in melancholic depression

Atrophy of bilateral nucleus accumbens in melancholic depression

Depression recurrence is accompanied by longer periods in default mode and more frequent attentional and reward processing dynamic brain‐states during resting‐state activity

Segregation of dynamic resting-state reward, default mode and attentional networks after remitted patients transition into a recurrent depressive episode

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