Neurobiological Mechanisms of the Placebo Effect

Benedetti, Fabrizio; Mayberg, Helen S.; Wager, Tor D.; Stohler, Christian S.; Zubieta, Jon-Kar

doi:10.1523/jneurosci.3458-05.2005

Cited by 615 publications

(431 citation statements)

References 121 publications

Supporting

Mentioning

394

Contrasting

Unclassified

Order By: Relevance

“…It has also been shown that use of therapies about which patients are unaware is less effective than using ones that patients are informed about. Placebo effects are the subject of scientific research aiming to understand underlying mechanisms [43]. Brain imaging techniques done by Emeran Mayer, Johanna Jarco and Matt Lieberman showed that placebo can have real, measurable effects on physiological changes in the brain [44].…”

Section: Transcutaneous Electrical Nerve Stimulation (Tens)mentioning

confidence: 99%

Non-Conventional Pain Management for Sickle Cell Disease

Al-Jafar¹

2017

Ann Hematol Oncol

View full text Add to dashboard Cite

Sickle cell disease is a congenital blood disorder affecting hemoglobin molecule. It leads to a rigid, sickle like shape red blood cell. Most people with sickle cell disease have severe painful episodes called vaso-occlusive crises. However, the frequency, severity, and duration of these crises vary tremendously. The pain is classified into two types, nociception pain which is intact peripheral or central nervous system and neuropathic pain which is initiated by dysfunction of the peripheral or central nervous system. Despite the pain being the most common complication of sickle cell disease, there is a lack of novel pain treatments. Pain killers including opioid have continued to be the main stay of therapy over the past several decades. A non-conventional treatments for pain were applied effectively to avoid the serious systemic side effects of the pharmaceutical pain killers.

show abstract

Section: Transcutaneous Electrical Nerve Stimulation (Tens)mentioning

confidence: 99%

Non-Conventional Pain Management for Sickle Cell Disease

Al-Jafar¹

2017

Ann Hematol Oncol

View full text Add to dashboard Cite

show abstract

“…There is evidence that the endogenous opioid system is implicated in the mediation of placebo effects under conditions of expectation of analgesia [8]. Using functional magnetic resonance imaging to measure, indirectly, neuronal activity during the administration of placebo with expectation of analgesia, Wager et al [9] showed a significant effect on the activation of the µ-opioid system (dorsolateral prefrontal cortex, rostral anterior cingulate, left nucleus accumbens and right anterior insula).…”

Section: Neurobiological Mechanismsmentioning

confidence: 99%

Lessons from placebo effects in migraine treatment

et al. 2007

View full text Add to dashboard Cite

In medical research, the placebo effect is an important methodological tool. Placebo is given to participants in clinical trials, with the intention of mimicking an experimental intervention. The "nocebo" effect, on the other hand, is the phenomenon whereby a patient who believes that a treatment will cause harm actually does experience adverse effects. The placebo effect strongly influences the way the results of clinical trials are interpreted. Placebo responses vary with the choice of study design, the choice of primary outcome measure, the characteristics of the patients and the cultural setting in which the trial is conducted. In migraine trials, the placebo response is high, in terms of both efficacy and side effects. Although medical ethics committees are becoming increasingly resistant to the use of placebo in acute migraine trials, placebo nevertheless remains the pivotal comparator in trials of migraine medications.

show abstract

“…One of the most common reasons for study failure is the unexpected and excessively high level of placebo response (Khan et al, 2003). The interactions between patients included in a trial and investigator at recruitment centers have been recognized as one of the major source of placebo response (Allan and Siegel, 2002;Trivedi and Rush, 1994;Benedetti et al 2005).…”

Section: Introductionmentioning

confidence: 99%

A Novel Methodology to Estimate the Treatment Effect in Presence of Highly Variable Placebo Response

Goméni¹,

Goyal

Bressolle³

et al. 2015

Neuropsychopharmacol

View full text Add to dashboard Cite

One of the main reasons for the inefficiency of multicenter randomized clinical trials (RCTs) in depression is the excessively high level of placebo response. The aim of this work was to propose a novel methodology to analyze RCTs based on the assumption that centers with high placebo response are less informative than the other centers for estimating the 'true' treatment effect (TE). A linear mixed-effect modeling approach for repeated measures (MMRM) was used as a reference approach. The new method for estimating TE was based on a nonlinear longitudinal modeling of clinical scores (NLMMRM). NLMMRM estimates TE by associating a weighting factor to the data collected in each center. The weight was defined by the posterior probability of detecting a clinically relevant difference between active treatment and placebo at that center. Data from five RCTs in depression were used to compare the performance of MMRM with NLMMRM. The results of the analyses showed an average improvement of~15% in the TE estimated with NLMMRM when the center effect was included in the analyses. Opposite results were observed with MMRM: TE estimate was reduced by~4% when the center effect was considered as covariate in the analysis. The novel NLMMRM approach provides a tool for controlling the confounding effect of high placebo response, to increase signal detection and to provide a more reliable estimate of the 'true' TE by controlling false negative results associated with excessively high placebo response.

show abstract

Neurobiological Mechanisms of the Placebo Effect

Cited by 615 publications

References 121 publications

Non-Conventional Pain Management for Sickle Cell Disease

Non-Conventional Pain Management for Sickle Cell Disease

Lessons from placebo effects in migraine treatment

A Novel Methodology to Estimate the Treatment Effect in Presence of Highly Variable Placebo Response

Contact Info

Product

Resources

About