Neurobiological mechanisms associated with facial affect recognition deficits after traumatic brain injury

Neumann, Dawn; McDonald, Brenna C.; West, John D.; Keiski, Michelle; Wang, Yan

doi:10.1007/s11682-015-9415-3

Cited by 15 publications

(18 citation statements)

References 44 publications

(74 reference statements)

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“…The fusiform gyrus, as well as several brain regions in the frontal lobe, have previously been shown to play a crucial role in affect recognition and processing, in particular facial affect recognition (Ganel, Valyear, Goshen‐Gottstein, & Goodale, ). Socio‐cognitive functions such as affect recognition have been shown to be impaired following moderate to severe TBI (McDonald, ; Ryan, Catroppa, Cooper, Beare, Ditchfield, Coleman, Silk, Crossley, Beauchamp, et al, ) and may therefore contribute to more general social dysfunction after TBI (Neumann, McDonald, West, Keiski, & Wang, ; Rosenberg, Dethier, Kessels, Westbrook, & McDonald, ). However, given no socio‐cognitive tasks were included in the present study, any association between the resting‐state fusiform findings and altered affect recognition remains speculative.…”

Section: Discussionmentioning

confidence: 99%

Altered resting‐state functional connectivity within the developing social brain after pediatric traumatic brain injury

Tuerk

Dégeilh

Catroppa

et al. 2019

Human Brain Mapping

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Traumatic brain injury (TBI) in childhood and adolescence can interrupt expected development, compromise the integrity of the social brain network (SBN) and impact social skills. Yet, no study has investigated functional alterations of the SBN following pediatric TBI. This study explored functional connectivity within the SBN following TBI in two independent adolescent samples. First, 14 adolescents with mild complex, moderate or severe TBI and 16 typically developing controls (TDC) underwent resting-state functional magnetic resonance imaging 12-24 months post-injury.Region of interest analyses were conducted to compare the groups' functional connectivity using selected SBN seeds. Then, replicative analysis was performed in an independent sample of adolescents with similar characteristics (9 TBI, 9 TDC). Results were adjusted for age, sex, socioeconomic status and total gray matter volume, and corrected for multiple comparisons. Significant between-group differences were detected for functional connectivity in the dorsomedial prefrontal cortex and left fusiform gyrus, and between the left fusiform gyrus and left superior frontal gyrus, indicating positive functional connectivity for the TBI group (negative for TDC). The replication study revealed group differences in the same direction between the left superior frontal gyrus and right fusiform gyrus. This study indicates that pediatric TBI may alter functional connectivity of the social brain. Frontal-fusiform connectivity has previously been shown to support affect recognition and changes in the function of this network could relate to more effortful processing and broad social impairments.

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Section: Discussionmentioning

confidence: 99%

Altered resting‐state functional connectivity within the developing social brain after pediatric traumatic brain injury

Tuerk

Dégeilh

Catroppa

et al. 2019

Human Brain Mapping

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“…The importance of the structural and functional integrity of secondary visual regions for facial-affect discrimination following TBI has previously been noted. In a structural study, Genova and colleagues used Voxel Based Morphometry to demonstrate that reduced gray matter volume in the parahippocampal and lingual gyrus was significantly related to emotion recognition skills in TBI (Genova et al, 2015); on a functional level, Neumann and colleagues found that in participants with TBI with facial-affect recognition impairment the only region showing significantly lower activation during an emotion labeling task was the fusiform gyrus (Neumann et al, 2015). In our study, the discrepancy of the results obtained by the contrast and the correlational analysis might indicate that a decrease in rs-FC within homotopic nodes of the affective network following TBI could lead to a reorganization of the connections supporting emotion recognition skills.…”

Section: Discussionmentioning

confidence: 99%

“…However, only one study has explored the relationship between white matter integrity and facial-affect recognition ability in individuals with moderate-severe TBI: Genova and colleagues (Genova et al, 2015) found that performance on emotion recognition tasks was positively correlated with fractional anisotropy of the inferior fronto-occipital and inferior longitudinal fasciculus, which connect visual regions with temporal and prefrontal areas involved in affective processing and decision making. Although no work has examined the relationship between rs-FC and facial-affect recognition abilities, a recent study by Neumann and colleagues compared blood oxygen level-dependent (BOLD) response during an emotion-labeling task between individuals with TBI and a matched comparison group (Neumann et al, 2015). The authors reported that individuals with TBI who had facial-affect recognition impairment showed less activation in the fusiform gyrus during an emotion-labeling task than those in the comparison group.…”

Section: Introductionmentioning

confidence: 99%

Relationship between individual differences in functional connectivity and facial-emotion recognition abilities in adults with traumatic brain injury

Rigon

Voss

Turkstra

et al. 2017

NeuroImage: Clinical

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Although several studies have demonstrated that facial-affect recognition impairment is common following moderate-severe traumatic brain injury (TBI), and that there are diffuse alterations in large-scale functional brain networks in TBI populations, little is known about the relationship between the two. Here, in a sample of 26 participants with TBI and 20 healthy comparison participants (HC) we measured facial-affect recognition abilities and resting-state functional connectivity (rs-FC) using fMRI. We then used network-based statistics to examine (A) the presence of rs-FC differences between individuals with TBI and HC within the facial-affect processing network, and (B) the association between inter-individual differences in emotion recognition skills and rs-FC within the facial-affect processing network. We found that participants with TBI showed significantly lower rs-FC in a component comprising homotopic and within-hemisphere, anterior-posterior connections within the facial-affect processing network. In addition, within the TBI group, participants with higher emotion-labeling skills showed stronger rs-FC within a network comprised of intra- and inter-hemispheric bilateral connections. Findings indicate that the ability to successfully recognize facial-affect after TBI is related to rs-FC within components of facial-affective networks, and provide new evidence that further our understanding of the mechanisms underlying emotion recognition impairment in TBI.

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“…Neuroimaging might provide another helpful tool, both on its own and in combination with hormonal measures. Recent works have attempted to uncover the precise brain regions underlying emotion recognition deficits following TBI by using both task-related functional magnetic resonance imaging approaches (Neumann, McDonald, West, Keiski, & Wang, 2015) and diffusion tensor imaging approaches (Genova et al, 2015). Although these studies have not examine the effect of sex-differences, imaging might be able to inform whether within healthy populations emotion recognition abilities are associate with different white-matter integrity levels or regional activation patterns in men and women, and to clarify whether brain injury in males preferentially targets these areas.…”

Section: Discussionmentioning

confidence: 99%

The female advantage: sex as a possible protective factor against emotion recognition impairment following traumatic brain injury

Rigon

Turkstra

Mutlu

et al. 2016

Cogn Affect Behav Neurosci

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Although moderate to severe traumatic brain injury (TBI) leads to facial affect recognition impairments in up to 39% of individuals, protective and risk factors for these deficits are unknown. The aim of the current study was to examine the effect of sex on emotion recognition abilities following TBI. We administered two separate emotion recognition tests (one static and one dynamic) to 53 individuals with moderate to severe TBI (Females=28) and 49 demographically matched comparisons (Females=22). We then investigated the presence of a sex-by-group interaction in emotion recognition accuracy. In the comparison group, there were no sex differences. In the TBI group, however, females significantly outperformed males in the dynamic (but not the static) task. Moreover, males (but not females) with TBI performed significantly worse than comparison participants in the dynamic task. Further analysis revealed that sex differences in emotion recognition abilities within the TBI group could not be explained by lesion location, TBI severity, or other neuropsychological variables. These findings suggest that sex may serve as a protective factor for social impairment following TBI and inform clinicians working with TBI as well as research on the neurophysiological correlates of sex differences in social functioning.

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Neurobiological mechanisms associated with facial affect recognition deficits after traumatic brain injury

Cited by 15 publications

References 44 publications

Altered resting‐state functional connectivity within the developing social brain after pediatric traumatic brain injury

Altered resting‐state functional connectivity within the developing social brain after pediatric traumatic brain injury

Relationship between individual differences in functional connectivity and facial-emotion recognition abilities in adults with traumatic brain injury

The female advantage: sex as a possible protective factor against emotion recognition impairment following traumatic brain injury

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