Neurobiological Markers of Resilience to Depression Following Childhood Maltreatment: The Role of Neural Circuits Supporting the Cognitive Control of Emotion

Rodman, Alexandra M.; Jenness, Jessica L.; Weissman, David G.; Pine, Daniel S.; McLaughlin, Katie A.

doi:10.1016/j.biopsych.2019.04.033

Cited by 114 publications

(67 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The concepts of resilience and vulnerability have enabled significant scientific advances. There are now elegant models of the structure of resilience factors for distress in the context of childhood adversity (Fritz, Fried, Goodyer, Wilkinson, & van Harmelen, 2018); of the brain mechanisms that may support mental well-being in the face of child maltreatment (Rodman, Jenness, Weissman, Pine, & McLaughlin, 2019); and of the genomic contributions to resilience in the context of life stress (Caspi, Hariri, Holmes, Uher, & Moffitt, 2010;Choi, Stein, Dunn, Koenen, & Smoller, 2019;Elbau, Cruceanu, & Binder, 2019). Therefore, studies on resilience and vulnerability are providing increasingly more comprehensive explanations for the heterogeneous clinical outcomes observed in traumatised children and will hopefully foster new intervention to buffer risk of psychopathology in this population.…”

Section: Which?mentioning

confidence: 99%

Annual Research Review: Rethinking childhood trauma‐new research directions for measurement, study design and analytical strategies

Danese

2019

Child Psychology Psychiatry

106

View full text Add to dashboard Cite

Childhood trauma is a key modifiable risk factor for psychopathology. Despite significant scientific advances, traumatised children still have poorer long‐term outcomes than nontraumatised children. New research paradigms are, thus, needed. To this end, the review examines three dominant assumptions about measurement, design and analytical strategies. Current research warns against using prospective and retrospective measures of childhood trauma interchangeably; against interpreting cross‐sectional differences in putative mediating mechanisms between adults with or without a history of childhood trauma as evidence of longitudinal changes from pre‐trauma conditions; and against directly applying explanatory models of resilience or vulnerability to psychopathology in traumatised children to forecast individual risk in unseen cases. The warnings equally apply to research on broader measures of adverse childhood experiences (ACEs). Further research examining these assumptions can generate new insights on how to prevent childhood trauma and its detrimental effects.

show abstract

Section: Which?mentioning

confidence: 99%

Annual Research Review: Rethinking childhood trauma‐new research directions for measurement, study design and analytical strategies

Danese

2019

Child Psychology Psychiatry

106

View full text Add to dashboard Cite

show abstract

“…This suggests that maltreated youth had to exert greater effort to modulate heightened amygdala responses (McLaughlin et al, 2015). Further, greater recruitment of prefrontal regions in these youth predicted lower risk for depression over time (Rodman, Jenness, Weissman, Pine, & McLaughlin, 2019).…”

Section: Cognitive Behavioral Approachesmentioning

confidence: 99%

Is There an Ace Up Our Sleeve? A Review of Interventions and Strategies for Addressing Behavioral and Neurobiological Effects of Adverse Childhood Experiences in Youth

2020

View full text Add to dashboard Cite

Exposure to early life adversity (ELA) is a major public health crisis posing as a significant risk of immediate and sustained mental and physical health consequences. While a remarkable body of knowledge has been amassed showing psychological, cognitive, social, developmental, and neurobiological consequences of ELA exposure, little has been done to improve the longterm mental and physical health outcomes for youth exposed to ELA. Furthermore, neurobiological processes underlying poor outcomes in this population have been largely left out of prevention and intervention target efforts. In this review, we first describe ELA-related alterations across psychological and neurobiological systems in children and adolescents. Next, we describe existing evidence-based interventions targeting ELA-related outcomes. We then turn to experimental studies examining individual differences in mechanistic functioning consequent to ELA exposure, and strategies that target these mechanisms and modulate disrupted functioning. Finally, we highlight areas of future research that may be promising in engaging behavioral and neurobiological targets through novel preventive interventions or augmentation of existing interventions, thereby reducing negative mental and physical health outcomes later in life.

show abstract

“…Cognitive re-appraisal The ability to re-evaluate experiences and their meaning has been identified as playing an important role in adaptive responses to trauma, as well forming a core part of many psychological therapies for posttraumatic stress disorders (Hofmann, 2008). Cognitive reappraisal has been described as an 'effortful emotion regulation strategy' that individuals may employ in order to buffer risk for adverse outcomes following trauma exposure (Rodman et al, 2019). In a recent ecological momentary assessment study carried out in currently-remitted individuals with a history of depression, individual differences in 'positive appraisal' (ability to "focus on positive meaning") were found to be mutually reinforcing of self-reported feelings of resilience and associated with lower occurrence of residual depressive symptoms (Hoorelbeke et al, 2019).…”

Section: Studies Of Potential Resilience Mechanismsmentioning

confidence: 99%

Neuroimaging resilience to trauma: convergent evidence and challenges for future research

Norbury¹,

Mm²,

Feder³

2019

Preprint

View full text Add to dashboard Cite

Resilience, or the phenomenon of successful adaptation following significant trauma exposure, is a complex, multidimensional, and dynamic process. To date, research on neural mechanisms involved in human resilience has comprised of two major research streams – involving individuals with childhood and adulthood trauma exposure, respectively. Although there are systematic differences in how both trauma and resilience have been defined across these two bodies of work, some striking regions of convergence emerge when considering the literature as a whole. Here, we review neuroimaging studies of resilience in both trauma-exposed individuals and the general population, alongside discussion of some of the methodological difficulties involved in quantifying trauma and resilience in human participants. Results highlight the involvement of brain networks implicated in emotion regulation (medial prefrontal cortex and amygdala), responses to rewards (ventral striatum and ventromedial prefrontal cortex), and attentional control and cognitive flexibility (prefrontal cortex and hippocampus) in fostering positive outcomes following trauma. There is also emerging evidence for a role of neural circuitry subserving interoceptive awareness (in particular, the anterior insula cortex) in resilience. Further, we discuss several ongoing issues in neuroimaging study design and analysis that will need to be addressed in order to enable us to harness insight from such studies to improve treatments for – or, ideally, guard against the development of – debilitating post-traumatic stress syndromes.

show abstract

Neurobiological Markers of Resilience to Depression Following Childhood Maltreatment: The Role of Neural Circuits Supporting the Cognitive Control of Emotion

Cited by 114 publications

References 118 publications

Annual Research Review: Rethinking childhood trauma‐new research directions for measurement, study design and analytical strategies

Annual Research Review: Rethinking childhood trauma‐new research directions for measurement, study design and analytical strategies

Is There an Ace Up Our Sleeve? A Review of Interventions and Strategies for Addressing Behavioral and Neurobiological Effects of Adverse Childhood Experiences in Youth

Neuroimaging resilience to trauma: convergent evidence and challenges for future research

Contact Info

Product

Resources

About