Neurobiological evidence for attention bias to food, emotional dysregulation, disinhibition and deficient somatosensory awareness in obesity with binge eating disorder

Aviram-Friedman, Roni; Astbury, Nerys M.; Ochner, Christopher N.; Contento, Isobel R.; Geliebter, Allan

doi:10.1016/j.physbeh.2017.11.003

Cited by 34 publications

(30 citation statements)

References 41 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, our exploratory analyses revealed that stronger baseline FC in the DMN and FPN was associated with enhanced cognitive control of eating behavior after surgery. Presurgery FC of the hippocampus with lingual gyrus (involved in food cue processing) and precentral gyrus was positively associated with reduced eating in response to emotions and external cues after surgery. The PCC coordinates internally directed attention , while the precuneus is involved in self‐centered mental imagery and consciousness or awareness .…”

Section: Discussionmentioning

confidence: 96%

Resting‐State Brain Connectivity Predicts Weight Loss and Cognitive Control of Eating Behavior After Vertical Sleeve Gastrectomy

Cerit

Davidson

Hye

et al. 2019

Obesity

View full text Add to dashboard Cite

Objective The effects of sleeve gastrectomy (SG) on functional connectivity (FC) and associations with weight loss and eating‐related cognitive control were investigated. Methods In a longitudinal study, 14 SG patients (13 female; 42.1 presurgery BMI) completed study visits 1 month pre surgery and 12 months post surgery. Patients completed the Dutch Eating Behavior Questionnaire and resting‐state functional magnetic resonance imaging scanning to measure FC. Data were analyzed using a seed‐to‐voxel approach in the CONN Toolbox to investigate pre‐/postsurgery changes (n = 12) and to conduct predictive analysis (n = 14). Results Seed‐to‐voxel analysis revealed changes in magnitude (decreases) and directionality (positively correlated to anticorrelated) of FC pre to post surgery within and between default mode network, salience network, and frontoparietal network nodes [Family‐Wise Error (FWE) corrected at P < 0.05]. Baseline FC of the nucleus accumbens (with insula) and hypothalamus (with precentral gyrus) predicted 12‐month post‐SG % total weight loss (FWE‐P < 0.05). Baseline FC of the hippocampus, frontoparietal network, and default mode network nodes predicted improvement in cognitive control of eating behavior 12 months after SG (FWE‐P < 0.05). Conclusions Our findings demonstrate changes in FC magnitude and directionality post versus pre surgery within and between resting‐state networks and frontal, paralimbic, and visual areas in SG patients. Baseline FC predicted weight loss and changes in cognitive control of food intake behavior at 12 months. These could serve as predictive biomarkers for bariatric surgery.

show abstract

Section: Discussionmentioning

confidence: 96%

Resting‐State Brain Connectivity Predicts Weight Loss and Cognitive Control of Eating Behavior After Vertical Sleeve Gastrectomy

Cerit

Davidson

Hye

et al. 2019

Obesity

View full text Add to dashboard Cite

show abstract

“…Anorexia nervosa (AN) is recognized as a severe mental disorder characterized by restrained eating, dysfunctional thoughts, preoccupation concerning food and body image disturbance [1,2]. In addition to maladaptive cognitions and behaviours, difficulties in emotion regulation and food craving regulation have been linked to disordered eating symptomatology (i.e., binging, purging, or restriction), which are considered to be contributing factors to the maintenance of eating disorders [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Neurophysiological Correlates of Emotion and Food Craving Regulation in Patients with Anorexia Nervosa

Mallorquí‐Bagué

Lozano‐Madrid

Testa

et al. 2020

JCM

View full text Add to dashboard Cite

Background: Difficulties in emotion regulation and craving regulation have been linked to eating symptomatology in patients with anorexia nervosa (AN), contributing to the maintenance of their eating disorder. Methods: To investigate clinical and electrophysiological correlates of these processes, 20 patients with AN and 20 healthy controls (HC) completed a computerized task during EEG recording, where they were instructed to down-regulate negative emotions or food craving. Participants also completed self-report measures of emotional regulation and food addiction. The P300 and Late Positive Potential (LPP) ERPs were analysed. Results: LPP amplitudes were significantly smaller during down-regulation of food craving among both groups. Independent of task condition, individuals with AN showed smaller P300 amplitudes compared to HC. Among HC, the self-reported use of re-appraisal strategies positively correlated with LPP amplitudes during emotional regulation task, while suppressive strategies negatively correlated with LPP amplitudes. The AN group, in comparison to the HC group, exhibited greater food addiction, greater use of maladaptive strategies, and emotional dysregulation. Conclusions: Despite the enhanced self-reported psychopathology among AN, both groups indicated neurophysiological evidence of food craving regulation as evidenced by blunted LPP amplitudes in the relevant task condition. Further research is required to delineate the mechanisms associated with reduced overall P300 amplitudes among individuals with AN.

show abstract

“…Converging data using different methodologies, such as brain imaging, eye tracking and behavioural test paradigms37 have found that patients with BED demonstrate a higher arousal rate in response to food stimuli, a concurrent motor plan to start eating, a higher reward sensitivity and greater inhibitory deficits as compared with individuals without BED 32 38 39. Those with obesity and BED (compared with obesity alone) have demonstrated that their attentional bias to food images held higher motivational value,40 and responded more to high calorie food images in sites of cognitive planning of motor movements, driven by emotions, which may reflect impulsive tendencies in the face of a binge-eating trigger. This tendency to approach and consume palatable food items may thus be compounded by a greater sensitivity to reward and a decreased capacity to inhibit action tendencies.…”

Section: Introductionmentioning

confidence: 99%

Combining cognitive bias modification training (CBM) and transcranial direct current stimulation (tDCS) to treat binge eating disorder: study protocol of a randomised controlled feasibility trial

et al. 2019

View full text Add to dashboard Cite

IntroductionBinge eating disorder (BED) is a common mental disorder, closely associated with obesity. Existing treatments are only moderately effective with high relapse rates, necessitating novel interventions. This paper describes the rationale for, and protocol of, a feasibility randomised controlled trial (RCT), evaluating the combination of transcranial direct current stimulation (tDCS) and a computerised cognitive training, namely approach bias modification training (ABM), in patients with BED who are overweight or obese. The aim of this trial is to obtain information that will guide decision-making and protocol development in relation to a future large-scale RCT of combined tDCS+ABM treatment in this group of patients, and also to assess the preliminary efficacy of this intervention.Methods and analysis66 participants with Diagnostic and Statistical Manual-5 diagnosis of BED and a body mass index (BMI) of ≥25 kg/m2 will be randomly allocated to one of three groups: ABM+real tDCS; ABM+sham tDCS or a wait-list control group. Participants in both intervention groups will receive six sessions of ABM+real/sham tDCS over 3 weeks; engaging in the ABM task while simultaneously receiving bilateral tDCS to the dorsolateral prefrontal cortex. ABM is based on an implicit learning paradigm in which participants are trained to enact an avoidance behaviour in response to visual food cues. Assessments will be conducted at baseline, post-treatment (3 weeks) and follow-up (7 weeks post-randomisation). Feasibility outcomes assess recruitment and retention rates, acceptability of random allocation, blinding success (allocation concealment), completion of treatment sessions and research assessments. Other outcomes include eating disorder psychopathology and related neurocognitive outcomes (ie, delay of gratification and inhibitory control), BMI, other psychopathology (ie, mood), approach bias towards food and surrogate endpoints (ie, food cue reactivity, trait food craving and food intake).Ethics and disseminationThis study has been approved by the North West-Liverpool East Research Ethics Committee. Results will be published in peer-reviewed journals.Trial registration number ISRCTN35717198

show abstract

Neurobiological evidence for attention bias to food, emotional dysregulation, disinhibition and deficient somatosensory awareness in obesity with binge eating disorder

Abstract: Food images elicited neural activity indicating attention bias (cuneate & PCG), emotion dysregulation (BA 19 & 32), and disinhibition (MFG, BA6 & SFG) in obese with BED. These may help tailor a treatment for the obesity with BED phenotype.

Cited by 34 publications

References 41 publications

Resting‐State Brain Connectivity Predicts Weight Loss and Cognitive Control of Eating Behavior After Vertical Sleeve Gastrectomy

Resting‐State Brain Connectivity Predicts Weight Loss and Cognitive Control of Eating Behavior After Vertical Sleeve Gastrectomy

Clinical and Neurophysiological Correlates of Emotion and Food Craving Regulation in Patients with Anorexia Nervosa

Combining cognitive bias modification training (CBM) and transcranial direct current stimulation (tDCS) to treat binge eating disorder: study protocol of a randomised controlled feasibility trial

Contact Info

Product

Resources

About