Neurobiological evaluation of thirty-one medicinal plant extracts using microtiter enzyme assays

Orhan, İlkay Erdoğan; Şenol, Fatma Sezer; Haznedaroğlu, Mehmet Zeki; Koyu, Halil; Erdem, Sinem Aslan; Yılmaz, Gülderen; Çiçek, Mehmet; Yaprak, Ahmet Emre; Ari, Esin; Küçükboyacı, Nurgun; Toker, Gülnur

doi:10.1186/s40816-016-0023-6

Cited by 13 publications

(3 citation statements)

References 42 publications

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“…Anticholinesterase Activity. Cholinesterase inhibitors (ChEIs) have recently become the most widely used drugs for the management of Alzheimer's disease (AD) [54]. ChEIs play a crucial role in the memory enhancement of AD patients through increasing ACh concentration in neural synaptic clefts and thus improving the brain cholinergic transmission and decreasing β-amyloid aggregation and neurotoxic fibrils formation [55][56][57].…”

Section: Enzyme Inhibitory Activities Of Essential Oilmentioning

confidence: 99%

Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti‐Alzheimer’s Disease Agents

Ali‐Shtayeh¹,

Abu-Zaitoun²,

Dudai

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Lavandula pubescens Decne (LP) is one of the three Lavandula species growing wildly in the Dead Sea Valley, Palestine. The products derived from the plant, including the essential oil (EO), have been used in Traditional Arabic Palestinian Herbal Medicine (TAPHM) for centuries as therapeutic agents. The EO is traditionally believed to have sedative, anti-inflammatory, antiseptic, antidepressive, antiamnesia, and antiobesity properties. This study was therefore aimed to assess the in vitro bioactivities associated with the LP EO. The EO was separated by hydrodistillation from the aerial parts of LP plants and analyzed for its antioxidant, antimicrobial, anticholinesterase, and antilipase activities. GC-MS was used for phytochemical analysis. The chemical analysis of the EO composition revealed 25 constituents, of which carvacrol (65.27%) was the most abundant. EO exhibited strong antioxidant (IC50 0.16–0.18 μL/mL), antiacetylcholinesterase (IC50 0.9 μL/mL), antibutyrylcholinesterase (IC50 6.82 μL/mL), and antilipase (IC50 1.08 μL/mL) effects. The EO also demonstrated high antibacterial activity with the highest susceptibility observed for Staphylococcus aureus with 95.7% inhibition. The EO was shown to exhibit strong inhibitory activity against Candida albicans (MIC 0.47 μL/mL). The EO was also shown to possess strong antidermatophyte activity against Microsporum canis, Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum (EC50 0.05–0.06 μL/mL). The high antioxidant, enzyme inhibitory, and antimicrobial potentials of the EO can, therefore, be correlated with its high content of monoterpenes, especially carvacrol, as shown by its comparable bioactivities indicators results. This study provided new insights into the composition and bioactivities of LP EO. Our finding revealed evidence that LP EO makes a valuable natural source of bioactive molecules showing substantial potential as antioxidant, neuroprotective, antihyperlipidemic, and antimicrobial agents. This study demonstrates, for the first time, that LP EO might be useful for further investigation aiming at integrative CAM and clinical applications in the management of dermatophytosis, Alzheimer’s disease, and obesity.

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Section: Enzyme Inhibitory Activities Of Essential Oilmentioning

confidence: 99%

Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti‐Alzheimer’s Disease Agents

Ali‐Shtayeh¹,

Abu-Zaitoun²,

Dudai

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Halk arasında usaresi yaygın olarak sinüzit ve sanlığa karşı gelişigüzel kullanılmaktadır [5]. Alzheimer hastalığına ilişkin asetilkolinesteraz (AChE) ve butirilkolinesteraz (BChE) ile Parkinson hastalığına ilişkin tirozinaz (TYR) inhibisyonu, bu hastalıklar için yeni ilaç adayları bulmak için önemli bir yaklaşımdır [6].…”

Section: Introductionunclassified

A Theoretical Investigation of the Effect of Some Active Agents in Ecballium elaterium on AChE and BChE

Gökalp¹

2019

acperpro

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It is a herbal medicine that is commonly used in the treatment of sinusitis among the people in the Mediterranean region of Ecballium elaterium, and has many pharmacological uses. The main therapeutic application for the treatment of Alzheimer's disease is the inhibition of AChE and BChE, i.e., cholinesterase enzymes. AChE and BChE are hydrolytic enzymes that hydrolyze the neurotransmitter acetylcholine. There are many active substances in painful heifers and it is very costly and time-consuming to isolate and investigate their individual activities. In order to shorten the process and eliminate the cost, the molecular bonding energies of some active substances in AChE and BChE were determined to determine the chemical activity of the molecules and the inhibitory effect on AChE and BChE by using the docking method related to the interactions and inhibition effects of the molecules, which have recently yielded very close results with experimental studies. theoretically compared.

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“…In our country, it has been determined that the roots of the plant were used as diaphoretic (Çakılcıoğlu and Türkoğlu 2010). Also, neurobiological activities were evaluated by Orhan et al 2016. The chemical components of V. hispanica are grouped as triterpenoid saponins, cyclic peptides, flavonoids, and others (Zhou et al 2015;.…”

Section: Introductionmentioning

confidence: 99%

Seed Morphology, Leaf Anatomy and Karyotype Analysis of the medicinal and ornamental plant; Vaccaria hispanica (Miller) Rauschert

Koçyiğıt

Alp

2018

Yüzüncü Yıl Üniversitesi Tarım Bilimleri Dergisi

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Vaccaria hispanica (Miller) Rauschert is a monotypic genus which is in the family Caryophyllaceae. The plant is known as ''Ekinebesi'' in Turkey. It has been recorded in pharmacopoeias and also it has been cultivated as ornamental plant in Canada. The leaf anatomy V. hispanica has been determined, seed and chromosome morphology have been confirmed in this study. Somatic chromosome number has been determined as 2n=30. Relative variation in chromosome length and mean centromeric asymmetry of the species has been estimated. The examined species has bifacial and amphistomatic leaf. The lower stomatal index was estimated at 27.14%, the upper stomatal index was estimated as 13.20%.

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Neurobiological evaluation of thirty-one medicinal plant extracts using microtiter enzyme assays

Cited by 13 publications

References 42 publications

Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti‐Alzheimer’s Disease Agents

Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti‐Alzheimer’s Disease Agents

A Theoretical Investigation of the Effect of Some Active Agents in Ecballium elaterium on AChE and BChE

Seed Morphology, Leaf Anatomy and Karyotype Analysis of the medicinal and ornamental plant; Vaccaria hispanica (Miller) Rauschert

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