Neurobiological and Molecular Bases of Methamphetamine-Induced Behavioral Sensitization and Spontaneous Recurrence of Methamphetamine Psychosis, and its Implication in Schizophrenia
Abstract:Spontaneous recurrence of methamphetamine-or amphetamine-induced paranoid hallucinatory psychosis (i.e., flashbacks) occasionally occurs in response to non-specific mild stress in drug-free patients with a history of methamphetamine-or amphetamine-induced psychosis. Stress sensitization associated with noradrenergic hyperactivity and increased dopamine release may be related to this flashbacks. Stressful frightening experiences as well as fear-related paranoid-hallucinatory states during methamphetamine use ma… Show more
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